Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Shirin Arastu-Kapur"'
Autor:
Shirin Arastu‐Kapur, Mai Nguyen, Debasish Raha, Florian Ermini, Ursula Haditsch, Joseph Araujo, Ines A. M. De Lannoy, Mark I. Ryder, Stephen S. Dominy, Casey Lynch, Leslie J. Holsinger
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)
Abstract COR388, a small‐molecule lysine‐gingipain inhibitor, is currently being investigated in a Phase 2/3 clinical trial for Alzheimer's disease (AD) with exploratory endpoints in periodontal disease. Gingipains are produced by two species of
Externí odkaz:
https://doaj.org/article/2e5935de51ed4fe1964b902269445d9f
Autor:
Michael B Winter, Florencia La Greca, Shirin Arastu-Kapur, Francesco Caiazza, Peter Cimermancic, Tonia J Buchholz, Janet L Anderl, Matthew Ravalin, Markus F Bohn, Andrej Sali, Anthony J O'Donoghue, Charles S Craik
Publikováno v:
eLife, Vol 6 (2017)
The immunoproteasome (iP) has been proposed to perform specialized roles in MHC class I antigen presentation, cytokine modulation, and T cell differentiation and has emerged as a promising therapeutic target for autoimmune disorders and cancer. Howev
Externí odkaz:
https://doaj.org/article/e24818c8dbee416fbc11f00f86293fde
Autor:
Erika Suzuki, Susan Demo, Edgar Deu, Jonathan Keats, Shirin Arastu-Kapur, P Leif Bergsagel, Mark K Bennett, Christopher J Kirk
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e27996 (2011)
Bortezomib (Velcade™) is a reversible proteasome inhibitor that is approved for the treatment of multiple myeloma (MM). Despite its demonstrated clinical success, some patients are deprived of treatment due to primary refractoriness or development
Externí odkaz:
https://doaj.org/article/0434396b744e445784f9e69f02b127b2
Falstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitates erythrocyte invasion.
Publikováno v:
PLoS Pathogens, Vol 2, Iss 11, p e117 (2006)
Erythrocytic malaria parasites utilize proteases for a number of cellular processes, including hydrolysis of hemoglobin, rupture of erythrocytes by mature schizonts, and subsequent invasion of erythrocytes by free merozoites. However, mechanisms used
Externí odkaz:
https://doaj.org/article/76b7f1eb2c0a4728badcfd1401afc915
Autor:
Christopher J. Kirk, Andrew J. Ball, Christoph Driessen, Mark K. Bennett, Tony Muchamuel, Susan J. Lee, Kevin D. Shenk, Francesco Parlati, Marianne Kraus, Janet L. Anderl, Shirin Arastu-Kapur
Supplementary Figures S1-S4; Supplementary Tables S1-S2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e20c3ba1cf4d484b2bffd0c91ffc79d
https://doi.org/10.1158/1078-0432.22442163.v1
https://doi.org/10.1158/1078-0432.22442163.v1
Autor:
Christopher J. Kirk, Andrew J. Ball, Christoph Driessen, Mark K. Bennett, Tony Muchamuel, Susan J. Lee, Kevin D. Shenk, Francesco Parlati, Marianne Kraus, Janet L. Anderl, Shirin Arastu-Kapur
Purpose: Bortezomib (Velcade), a dipeptide boronate 20S proteasome inhibitor and an approved treatment option for multiple myeloma, is associated with a treatment-emergent, painful peripheral neuropathy (PN) in more than 30% of patients. Carfilzomib,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0675242182dc136a28da04501a408a42
https://doi.org/10.1158/1078-0432.c.6518973
https://doi.org/10.1158/1078-0432.c.6518973
Autor:
Sean Broce, Florian Ermini, Leslie J. Holsinger, Stephen S. Dominy, Michael J. Detke, Leo Rodriguez, Ursula Haditsch, Casey C. Lynch, D. David Hennings, Mai Nguyen, Jianhong Wang, Shirin Arastu-Kapur, Debasish Raha
Publikováno v:
SSRN Electronic Journal.
Gingipains are protease virulence factors from the periodontal bacterial pathogen Porphyromonas gingivalis and were recently identified in greater than 90% of Alzheimer’s disease (AD) brains. Studies in wild-type mice and rats have demonstrated tha
Autor:
Florian Ermini, Debasish Raha, Mai Nguyen, Leslie J. Holsinger, Casey C. Lynch, Mark I. Ryder, Stephen S. Dominy, Ines A. M. De Lannoy, Ursula Haditsch, Joseph Araujo, Shirin Arastu-Kapur
Publikováno v:
Pharmacology Research & Perspectives
Pharmacology research & perspectives, vol 8, iss 1
Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)
Pharmacology research & perspectives, vol 8, iss 1
Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)
COR388, a small‐molecule lysine‐gingipain inhibitor, is currently being investigated in a Phase 2/3 clinical trial for Alzheimer's disease (AD) with exploratory endpoints in periodontal disease. Gingipains are produced by two species of bacteria,
Autor:
Erin Bradley, Lisa M. Kelly, Janet L. Anderl, Eric Lowe, David C. Moebius, Jeffrey Jones, Shirin Arastu-Kapur, Christopher J. Kirk, Henry W. B. Johnson, John Bui, Zhengping Wang, Dustin McMinn, Tony Muchamuel
Publikováno v:
ACS Medicinal Chemistry Letters. 8:413-417
Building upon the success of bortezomib (VELCADE) and carfilzomib (KYPROLIS), the design of a next generation of inhibitors targeting specific subunits within the immunoproteasome is of interest for the treatment of autoimmune disease. There are thre
Autor:
Marcin Drag, Fang Yuan, Katarzyna Groborz, Martin Horn, Edgar Deu, Chrislaine Withers-Martinez, Laurie Kuppens, Neysa Nevins, Shirin Arastu-Kapur, Matthew Bogyo, Michael Mareš, Mateo I. Sánchez, Christine Lehmann, David Jonathan Hirst, Marcin Poreba, Laura E. de Vries
Publikováno v:
FEBS Journal, 286, 20, pp. 3998-4023
The Febs Journal
FEBS Journal, 286, 3998-4023
The Febs Journal
FEBS Journal, 286, 3998-4023
Malarial dipeptidyl aminopeptidases (DPAPs) are cysteine proteases important for parasite development thus making them attractive drug targets. In order to develop inhibitors specific to the parasite enzymes, it is necessary to map the determinants o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119003c3d9face13e10fdaba3ed3a2db
https://hdl.handle.net/2066/209409
https://hdl.handle.net/2066/209409