Human mitochondria require mtRF1 for translation termination at non-canonical stop codons.

Autor: Krüger A; Department of Medical Biochemistry and Biophysics, Division of Molecular Metabolism, Karolinska Institutet, Biomedicum, 171 65, Solna, Sweden.; Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden., Remes C; Department of Chemistry, University of Pennsylvania, Philadelphia, PA, 19104, USA., Shiriaev DI; Department of Medical Biochemistry and Biophysics, Division of Molecular Metabolism, Karolinska Institutet, Biomedicum, 171 65, Solna, Sweden.; Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden., Liu Y; Department of Medical Biochemistry and Biophysics, Division of Molecular Metabolism, Karolinska Institutet, Biomedicum, 171 65, Solna, Sweden.; Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden., Spåhr H; Department of Medical Biochemistry and Biophysics, Division of Molecular Metabolism, Karolinska Institutet, Biomedicum, 171 65, Solna, Sweden.; Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden., Wibom R; Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden., Atanassov I; Proteomics Core Facility, Max-Planck-Institute for Biology of Ageing, Joseph-Stelzmann-Str. 9b, 50931, Cologne, Germany., Nguyen MD; Department of Medical Biochemistry and Biophysics, Division of Molecular Metabolism, Karolinska Institutet, Biomedicum, 171 65, Solna, Sweden.; Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden., Cooperman BS; Department of Chemistry, University of Pennsylvania, Philadelphia, PA, 19104, USA., Rorbach J; Department of Medical Biochemistry and Biophysics, Division of Molecular Metabolism, Karolinska Institutet, Biomedicum, 171 65, Solna, Sweden. Joanna.rorbach@ki.se.; Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, Stockholm, Sweden. Joanna.rorbach@ki.se.; S.T.I.A.S: Stellenbosch Institute for Advanced Study, Marais Rd, Mostertsdrift, Stellenbosch, 7600, South Africa. Joanna.rorbach@ki.se.

Publikováno v: Nature communications [Nat Commun] 2023 Jan 03; Vol. 14 (1), pp. 30. Date of Electronic Publication: 2023 Jan 03.

Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel.

Autor: Osterman IA; Center of Life Sciences, Skolkovo Institute of Science and Technology, Skolkovo, Russia. i.osterman@skoltech.ru.; Department of Chemistry, Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia. i.osterman@skoltech.ru., Wieland M; Institute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany., Maviza TP; Center of Life Sciences, Skolkovo Institute of Science and Technology, Skolkovo, Russia., Lashkevich KA; Department of Chemistry, Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia., Lukianov DA; Center of Life Sciences, Skolkovo Institute of Science and Technology, Skolkovo, Russia., Komarova ES; Center of Life Sciences, Skolkovo Institute of Science and Technology, Skolkovo, Russia.; Department of Chemistry, Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia., Zakalyukina YV; Department of Soil Science and Department of Biology, Lomonosov Moscow State University, Moscow, Russia., Buschauer R; Gene Center, Department of Biochemistry, University of Munich, Munich, Germany., Shiriaev DI; Department of Chemistry, Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia., Leyn SA; Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.; A.A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia., Zlamal JE; Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Biryukov MV; Department of Soil Science and Department of Biology, Lomonosov Moscow State University, Moscow, Russia., Skvortsov DA; Department of Chemistry, Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia., Tashlitsky VN; Department of Chemistry, Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia., Polshakov VI; Center for Magnetic Tomography and Spectroscopy, Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russia., Cheng J; Gene Center, Department of Biochemistry, University of Munich, Munich, Germany., Polikanov YS; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL, USA., Bogdanov AA; Department of Chemistry, Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia., Osterman AL; Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Dmitriev SE; Department of Chemistry, Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia., Beckmann R; Gene Center, Department of Biochemistry, University of Munich, Munich, Germany., Dontsova OA; Center of Life Sciences, Skolkovo Institute of Science and Technology, Skolkovo, Russia.; Department of Chemistry, Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia., Wilson DN; Institute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany. Daniel.Wilson@chemie.uni-hamburg.de., Sergiev PV; Center of Life Sciences, Skolkovo Institute of Science and Technology, Skolkovo, Russia. petya@genebee.msu.su.; Department of Chemistry, Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia. petya@genebee.msu.su.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2020 Oct; Vol. 16 (10), pp. 1071-1077. Date of Electronic Publication: 2020 Jun 29.

Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to the E. coli 70S ribosome.

Autor: Pichkur EB; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of NRC 'Kurchatov Institute,' Gatchina, 188300, Russia.; National Research Center 'Kurchatov Institute,' Moscow, 123182, Russia., Paleskava A; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of NRC 'Kurchatov Institute,' Gatchina, 188300, Russia.; Peter the Great St. Petersburg Polytechnic University, Saint Petersburg, 195251, Russia., Tereshchenkov AG; Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia., Kasatsky P; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of NRC 'Kurchatov Institute,' Gatchina, 188300, Russia., Komarova ES; Department of Bioengineering and Bioinformatics and A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia.; Skolkovo Institute of Science and Technology, Skolkovo, Moscow region, 143025, Russia., Shiriaev DI; Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia., Bogdanov AA; Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia., Dontsova OA; Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia.; Skolkovo Institute of Science and Technology, Skolkovo, Moscow region, 143025, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia., Osterman IA; Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia.; Skolkovo Institute of Science and Technology, Skolkovo, Moscow region, 143025, Russia., Sergiev PV; Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia.; Skolkovo Institute of Science and Technology, Skolkovo, Moscow region, 143025, Russia., Polikanov YS; Departments of Biological Sciences and Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois 60607, USA.; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, Illinois 60607, USA., Myasnikov AG; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of NRC 'Kurchatov Institute,' Gatchina, 188300, Russia.; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.; Centre for Integrative Biology, IGBMC, CNRS, Inserm, Université de Strasbourg, Illkirch, 67404, France., Konevega AL; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of NRC 'Kurchatov Institute,' Gatchina, 188300, Russia.; National Research Center 'Kurchatov Institute,' Moscow, 123182, Russia.; Peter the Great St. Petersburg Polytechnic University, Saint Petersburg, 195251, Russia.

Publikováno v: RNA (New York, N.Y.) [RNA] 2020 Jun; Vol. 26 (6), pp. 715-723. Date of Electronic Publication: 2020 Mar 06.

Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides.

Autor: Khabibullina NF; Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA., Tereshchenkov AG; Department of Chemistry and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia., Komarova ES; Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.; Skolkovo Institute of Science and Technology, Skolkovo, Russia., Syroegin EA; Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA., Shiriaev DI; Department of Chemistry and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia., Paleskava A; Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, Gatchina, Russia.; Peter the Great St. Petersburg Polytechnic University, Saint Petersburg, Russia., Kartsev VG; Interbioscreen, Ltd., Chernogolovka, Russia., Bogdanov AA; Department of Chemistry and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia., Konevega AL; Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, Gatchina, Russia.; Peter the Great St. Petersburg Polytechnic University, Saint Petersburg, Russia.; NRC Kurchatov Institute, Moscow, Russia., Dontsova OA; Department of Chemistry and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.; Skolkovo Institute of Science and Technology, Skolkovo, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia., Sergiev PV; Department of Chemistry and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.; Skolkovo Institute of Science and Technology, Skolkovo, Russia., Osterman IA; Department of Chemistry and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia i.osterman@skoltech.ru yuryp@uic.edu.; Skolkovo Institute of Science and Technology, Skolkovo, Russia., Polikanov YS; Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA i.osterman@skoltech.ru yuryp@uic.edu.; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois, USA.; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2019 May 24; Vol. 63 (6). Date of Electronic Publication: 2019 May 24 (Print Publication: 2019).