Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors

Autor: Shiri Kult, Tsviya Olender, Marco Osterwalder, Svetalana Markman, Dena Leshkowitz, Sharon Krief, Ronnie Blecher-Gonen, Shani Ben-Moshe, Lydia Farack, Hadas Keren-Shaul, Tomer-Meir Salame, Terence D Capellini, Shalev Itzkovitz, Ido Amit, Axel Visel, Elazar Zelzer

Publikováno v: eLife, Vol 10 (2021)

The mechanical challenge of attaching elastic tendons to stiff bones is solved by the formation of a unique transitional tissue. Here, we show that murine tendon-to-bone attachment cells are bi-fated, activating a mixture of chondrocyte and tenocyte

Externí odkaz: https://doaj.org/article/d634c0b6552b4485bd6640c59f2a7db5

Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors

Autor: Tomer-Meir Salame, Ronnie Blecher-Gonen, Elazar Zelzer, Shani Ben-Moshe, Svetalana Markman, Axel Visel, Shalev Itzkovitz, Shiri Kult, Marco Osterwalder, Tsviya Olender, Ido Amit, Hadas Keren-Shaul, Dena Leshkowitz, Terence D. Capellini, Lydia Farack, Sharon Krief

Publikováno v: eLife
Kult, Shiri; Olender, Tsviya; Osterwalder, Marco; Markman, Svetalana; Leshkowitz, Dena; Krief, Sharon; Blecher-Gonen, Ronnie; Ben-Moshe, Shani; Farack, Lydia; Keren-Shaul, Hadas; Salame, Tomer-Meir; Capellini, Terence D; Itzkovitz, Shalev; Amit, Ido; Visel, Axel; Zelzer, Elazar (2021). Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors. eLife, 10 eLife Sciences Publications 10.7554/eLife.55361
eLife, Vol 10 (2021)

The mechanical challenge of attaching elastic tendons to stiff bones is solved by the formation of a unique transitional tissue. Here, we show that murine tendon-to-bone attachment cells are bi-fated, activating a mixture of chondrocyte and tenocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2298c0e9d98e00559b38da52229f851
https://escholarship.org/uc/item/5x81k2fg

Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors

Autor: Tsviya Olender, Axel Visel, Tomer-Meir Salame, Shalev Itzkovitz, Shiri Kult, Lydia Farack, Ido Amit, Hadas Keren-Shaul, Sharon Krief, Marco Osterwalder, Dena Leshkowitz, Shani Ben-Moshe, Elazar Zelzer, Ronnie Blecher-Gonen, Terence D. Capellini

The connection between different tissues is vital for the development and function of any organs and systems. In the musculoskeletal system, the attachment of elastic tendons to stiff bones poses a mechanical challenge that is solved by the formation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99090c887741e86a86b8cb057293c6e5
https://escholarship.org/uc/item/7233f317

Bone morphology is regulated modularly by global and regional genetic programs

Autor: Shai Eyal, Yoseph Addadi, Sarah Rubin, Deneen M. Wellik, Kyriel M. Pineault, Shiri Kult, Tomer-Meir Salame, Dena Leshkowitz, Elazar Zelzer, Sharon Krief, Neta Felsenthal

Publikováno v: Development

Bone protrusions provide stable anchoring sites for ligaments and tendons and define the unique morphology of each long bone. Despite their importance, the mechanism by which superstructures are patterned is unknown. Here, we identify components of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1232e9e46d434e30c3a0eab0dc5a16
https://pubmed.ncbi.nlm.nih.gov/31221640

Fluorescent Cell Staining Methods for Living Hypsibius exemplaris Embryos

Autor: Marla E. Tharp, Kira L. Heikes, Bob Goldstein, Kristen M. McGreevy, Shiri Kult

Publikováno v: Cold Spring Harbor Protocols. 2018:pdb.prot106021

The tardigrade Hypsibius exemplaris was chosen as a model system in part because animals and embryos are optically clear at all stages, facilitating the visualization of events in living material. Here we report new methods for introducing fluorescen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f82c7881e6fcafb372af5cda76fe6534
https://doi.org/10.1101/pdb.prot106021