Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling

Autor: Eman Khatib-Massalha, Suditi Bhattacharya, Hassan Massalha, Adi Biram, Karin Golan, Orit Kollet, Anju Kumari, Francesca Avemaria, Ekaterina Petrovich-Kopitman, Shiri Gur-Cohen, Tomer Itkin, Isabell Brandenburger, Asaf Spiegel, Ziv Shulman, Zachary Gerhart-Hines, Shalev Itzkovitz, Matthias Gunzer, Stefan Offermanns, Ronen Alon, Amiram Ariel, Tsvee Lapidot

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)

Lactate is a by-product of glycolysis that can function via its G protein receptor GPR81. Here the authors show that LPS or Salmonella infection enhances glycolytic metabolism in bone marrow neutrophils, resulting in lactate production, which increas

Externí odkaz: https://doaj.org/article/fd9905e2c6a74145a36f74cbae797fa7

Stem cells repurpose proliferation to contain a breach in their niche barrier

Autor: Kenneth Lay, Shaopeng Yuan, Shiri Gur-Cohen, Yuxuan Miao, Tianxiao Han, Shruti Naik, H Amalia Pasolli, Samantha B Larsen, Elaine Fuchs

Publikováno v: eLife, Vol 7 (2018)

Adult stem cells are responsible for life-long tissue maintenance. They reside in and interact with specialized tissue microenvironments (niches). Using murine hair follicle as a model, we show that when junctional perturbations in the niche disrupt

Externí odkaz: https://doaj.org/article/e217a64595114d78aad05d549c5117f9

VLA-4 Affinity Assay for Murine Bone Marrow-derived Hematopoietic Stem Cells

Autor: Francesca Avemaria, Shiri Gur-Cohen, Seymen Avci, Tsvee Lapidot

Publikováno v: Bio-Protocol, Vol 7, Iss 4 (2017)

Hematopoietic stem cells (HSCs) are defined by their functional ability to self-renew and to differentiate into all blood cell lineages. The majority of HSC reside in specific anatomical locations in the bone marrow (BM) microenvironment, in a quiesc

Externí odkaz: https://doaj.org/article/130b56b2af3b4049b7f58488b7cc5f41

Lymphatics act as a signaling hub to regulate intestinal stem cell activity

Autor: Rachel E. Niec, Tinyi Chu, Marina Schernthanner, Shiri Gur-Cohen, Lynette Hidalgo, Hilda Amalia Pasolli, Kathleen A. Luckett, Zhong Wang, Sohni R. Bhalla, Francesco Cambuli, Raghu P. Kataru, Karuna Ganesh, Babak J. Mehrara, Dana Pe’er, Elaine Fuchs

Publikováno v: Cell Stem Cell

Barrier epithelia depend upon resident stem cells for homeostasis, defense, and repair. Epithelial stem cells of small and large intestines (ISCs) respond to their local microenvironments (niches) to fulfill a continuous demand for tissue turnover. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787e9f5c4c09349aa499167391ff701f
https://europepmc.org/articles/PMC9271639/

Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling

Autor: Asaf Spiegel, Hassan Massalha, Shalev Itzkovitz, Orit Kollet, Eman Khatib-Massalha, Isabell Brandenburger, Suditi Bhattacharya, Francesca Avemaria, Ronen Alon, Ziv Shulman, Zachary Gerhart-Hines, Amiram Ariel, Tsvee Lapidot, Tomer Itkin, Adi Biram, Karin Golan, Ekaterina Petrovich-Kopitman, Anju Kumari, Stefan Offermanns, Matthias Gunzer, Shiri Gur-Cohen

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Khatib-Massalha, E, Bhattacharya, S, Massalha, H, Biram, A, Golan, K, Kollet, O, Kumari, A, Avemaria, F, Petrovich-Kopitman, E, Gur-Cohen, S, Itkin, T, Brandenburger, I, Spiegel, A, Shulman, Z, Gerhart-Hines, Z, Itzkovitz, S, Gunzer, M, Offermanns, S, Alon, R, Ariel, A & Lapidot, T 2020, ' Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling ', Nature Communications, vol. 11, no. 1, 3547 . https://doi.org/10.1038/s41467-020-17402-2

Neutrophils provide first line of host defense against bacterial infections utilizing glycolysis for their effector functions. How glycolysis and its major byproduct lactate are triggered in bone marrow (BM) neutrophils and their contribution to neut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667e4c7ed3f2c2e96b61e3d338fc5f95
http://link.springer.com/article/10.1038/s41467-020-17402-2