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Akademický článek

Structure-Based Optimization of Selective and Brain Penetrant CK1δ Inhibitors for the Treatment of Circadian Disruptions.

Autor: McCarver S; Janssen Research and Development, San Diego, California 92121-1126, United States., Hanna L; Janssen Research and Development, San Diego, California 92121-1126, United States., Samant A; Janssen Research and Development, San Diego, California 92121-1126, United States., Thompson AA; Janssen Research and Development, San Diego, California 92121-1126, United States., Seierstad M; Janssen Research and Development, San Diego, California 92121-1126, United States., Saha A; Janssen Research and Development, San Diego, California 92121-1126, United States., Wu D; Janssen Research and Development, San Diego, California 92121-1126, United States., Lord B; Janssen Research and Development, San Diego, California 92121-1126, United States., Sutton SW; Janssen Research and Development, San Diego, California 92121-1126, United States., Shah V; Janssen Research and Development, San Diego, California 92121-1126, United States., Milligan CM; Janssen Research and Development, San Diego, California 92121-1126, United States., Wennerholm M; Janssen Research and Development, San Diego, California 92121-1126, United States., Shelton J; Janssen Research and Development, San Diego, California 92121-1126, United States., Lebold TP; Janssen Research and Development, San Diego, California 92121-1126, United States., Shireman BT; Janssen Research and Development, San Diego, California 92121-1126, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 Mar 07; Vol. 15 (4), pp. 486-492. Date of Electronic Publication: 2024 Mar 07 (Print Publication: 2024).

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Akademický článek

Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D).

Autor: Wang J; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States. Electronic address: jwang301@its.jnj.com., Nakafuku KM; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States. Electronic address: knakafuk@its.jnj.com., Ziff J; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Gelin CF; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Gholami H; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Thompson AA; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Karpowich NK; Janssen Research & Development L.L.C., 1400 McKean Rd., Spring House, PA 19477, United States., Limon L; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Coate HR; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Damm-Ganamet KL; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Shih AY; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Grant JC; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Côte M; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Mak PA; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Pascual HA; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Rives ML; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Edwards JP; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Venable JD; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Venkatesan H; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Shi Z; Janssen Research & Development L.L.C., 1400 McKean Rd., Spring House, PA 19477, United States., Allen SJ; Janssen Research & Development L.L.C., 1400 McKean Rd., Spring House, PA 19477, United States., Sharma S; Janssen Research & Development L.L.C., 1400 McKean Rd., Spring House, PA 19477, United States., Kung PP; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Shireman BT; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Nov 15; Vol. 96, pp. 129492. Date of Electronic Publication: 2023 Sep 29.

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Akademický článek

Identification of small-molecule protein-protein interaction inhibitors for NKG2D.

Autor: Thompson AA; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Harbut MB; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Kung PP; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Karpowich NK; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Branson JD; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Grant JC; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Hagan D; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Pascual HA; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Bai G; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Zavareh RB; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Coate HR; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Collins BC; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Côte M; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Gelin CF; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Damm-Ganamet KL; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Gholami H; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Huff AR; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Limon L; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Lumb KJ; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Mak PA; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Nakafuku KM; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Price EV; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Shih AY; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Tootoonchi M; Discovery Immunology, Janssen Research & Development, San Diego, CA 92121., Vellore NA; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Wang J; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Wei N; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Ziff J; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Berger SB; Discovery Immunology, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Edwards JP; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Gardet A; Discovery Immunology, Janssen Research & Development, San Diego, CA 92121., Sun S; Discovery Immunology, Janssen Research & Development, San Diego, CA 92121., Towne JE; Discovery Immunology, Janssen Research & Development, San Diego, CA 92121., Venable JD; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Shi Z; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Venkatesan H; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Rives ML; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Sharma S; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Shireman BT; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Allen SJ; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 May 02; Vol. 120 (18), pp. e2216342120. Date of Electronic Publication: 2023 Apr 25.

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Akademický článek

Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans.

Autor: Salvadore G; Janssen Research & Development, LLC, Titusville, NJ, USA., Bonaventure P; Janssen Research & Development, LLC, San Diego, CA, USA. pbonave1@its.jnj.com., Shekhar A; Departments of Psychiatry, and Pharmacology, Indiana University, School of Medicine, Indianapolis, IN, USA., Johnson PL; Department of Anatomy, Physiology and Cell Biology, Indiana University, School of Medicine, Indianapolis, IN, USA., Lord B; Janssen Research & Development, LLC, San Diego, CA, USA., Shireman BT; Janssen Research & Development, LLC, San Diego, CA, USA., Lebold TP; Janssen Research & Development, LLC, San Diego, CA, USA., Nepomuceno D; Janssen Research & Development, LLC, San Diego, CA, USA., Dugovic C; Janssen Research & Development, LLC, San Diego, CA, USA., Brooks S; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Center, Leiden, The Netherlands., Zuiker R; Centre for Human Drug Research, Leiden, The Netherlands., Bleys C; Janssen Research & Development, LLC, Beerse, Belgium., Tatikola K; Janssen Scientific Affairs, LLC, Titusville, NJ, USA., Remmerie B; Janssen Research & Development, LLC, Beerse, Belgium., Jacobs GE; Centre for Human Drug Research, Leiden, The Netherlands.; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands., Schruers K; Research School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands., Moyer J; Janssen Research & Development, LLC, Titusville, NJ, USA., Nash A; Janssen Scientific Affairs, LLC, Titusville, NJ, USA., Van Nueten LGM; Janssen Research & Development, LLC, Beerse, Belgium., Drevets WC; Janssen Research & Development, LLC, San Diego, CA, USA.

Publikováno v: Translational psychiatry [Transl Psychiatry] 2020 Sep 07; Vol. 10 (1), pp. 308. Date of Electronic Publication: 2020 Sep 07.

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