Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Shireen S. Rudina"'
Autor:
Melina Mathur, Cameron M. Kim, Sarah A. Munro, Shireen S. Rudina, Eric M. Sawyer, Christina D. Smolke
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Alternative splicing expands the genetic coding capacity and proteomic diversity of the cell. Here the authors create a synthetic biology platform for regulating four programmable exons in modular transcription factors.
Externí odkaz:
https://doaj.org/article/f2ae05290582465fb58220b0ccf48cb8
Autor:
Cameron M. Kim, Sarah A. Munro, Shireen S. Rudina, Melina Mathur, Eric M. Sawyer, Christina D. Smolke
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Alternative splicing performs a central role in expanding genomic coding capacity and proteomic diversity. However, programming of splicing patterns in engineered biological systems remains underused. Synthetic approaches thus far have predominantly
Autor:
Christina D. Smolke, Shireen S. Rudina
Long-term stable expression of transgenes in mammalian cells is a challenge in gene therapy, recombinant protein production, and mammalian synthetic biology due to epigenetic silencing and position effect variegation. While multiple classes of regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5c8dbd8ff492f8180ce98c9f0700f8
https://doi.org/10.1101/626713
https://doi.org/10.1101/626713
Autor:
Douglas A. Lauffenburger, Shannon K. Hughes-Alford, Jenny Tadros, Richard O. Hynes, Shireen S. Rudina, Daisy N. Riquelme, Frank B. Gertler, Stephanie L. Gupton
Publikováno v:
The Journal of Cell Biology
Rockefeller UP
Rockefeller UP
Mena is an Ena/VASP family actin regulator with roles in cell migration, chemotaxis, cell–cell adhesion, tumor cell invasion, and metastasis. Although enriched in focal adhesions, Mena has no established function within these structures. We find th
Autor:
Borja Salvador-Culla, Cristina F. Stefanescu, Fabiano Cade, Shireen S. Rudina, Joseph B. Ciolino, Sunia A. Trauger, Daniel R. Mascoop, Sarah L. Sprague, Eden M. Ford, Kate A. Wymbs, Priscila Cortez, Amy E. Ross, Daniel S. Kohane
For nearly half a century, contact lenses have been proposed as a means of ocular drug delivery, but achieving controlled drug release has been a significant challenge. We have developed a drug-eluting contact lens designed for prolonged delivery of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6283e62315820daac38e793323ed1ed7
https://europepmc.org/articles/PMC3874329/
https://europepmc.org/articles/PMC3874329/