Behavioral testing affects the phenotypic expression of APOE ε3 and APOE ε4 in targeted replacement mice and reduces the differences between them

Autor: Shiran Salomon‐Zimri, Ori Liraz, Daniel M. Michaelson

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 1, Iss 2, Pp 127-135 (2015)

Abstract Apolipoprotein E4 (APOE ε4) is the most prevalent genetic risk factor for Alzheimer's disease (AD). Targeted replacement mice that express either APOE ε4 or its AD benign isoform, APOE ε3, are used extensively in behavioral, biochemical,

Externí odkaz: https://doaj.org/article/41a366fb7ee44bd7a0410cdcdd184814

The Role of MAPK's Signaling in Mediating ApoE4-Driven Pathology In Vivo

Autor: Tali Ben-Zur, Shiran Salomon-Zimri, Amit Koren, Ariel Angel, Daniel M. Michaelson, Daniel Offen

Publikováno v: Current Alzheimer Research. 16:281-292

Background: Alzheimer's Disease (AD) is associated with impairments in key brain Mitogen- Activated Protein Kinase (MAPK) signaling cascades including the p38, c-Jun N-terminal kinase (JNK), ERK and Akt pathways. Apolipoprotein E4 (ApoE4) is the most

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07abdd5a07f55b14146a87edd10bf00
https://doi.org/10.2174/1567205016666190228120254

Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment

Autor: Anat Boehm-Cagan, Daniel M. Michaelson, Ori Liraz, Daniel Offen, Shiran Salomon-Zimri, Yael Barhum, Tali Ben-Zur, Micaela Johanna Glat, Ishai Luz

Publikováno v: Journal of Alzheimer's Disease. 53:1443-1458

Apolipoprotein E4 (ApoE4), the most prevalent genetic risk factor for Alzheimer's disease (AD), is associated with increased neurodegeneration and vascular impairments. Vascular endothelial growth factor (VEGF), originally described as a key angiogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cff38fcde71f1960136c268f52ccf670
https://doi.org/10.3233/jad-160182

Behavioral testing affects the phenotypic expression of APOE ε3 and APOE ε4 in targeted replacement mice and reduces the differences between them

Autor: Ori Liraz, Daniel M. Michaelson, Shiran Salomon-Zimri

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 1, Iss 2, Pp 127-135 (2015)
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring

Apolipoprotein E4 (APOE ε4) is the most prevalent genetic risk factor for Alzheimer's disease (AD). Targeted replacement mice that express either APOE ε4 or its AD benign isoform, APOE ε3, are used extensively in behavioral, biochemical, and physi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa849f8d670d112f5ffce34bdff55398
https://doi.org/10.1016/j.dadm.2014.11.014

VEGF Mediates ApoE4-Induced Neovascularization and Synaptic Pathology in the Choroid and Retina

Autor: Marina Garcia Garrido, Ran Antes, Daniel M. Michaelson, Dov Weinberger, Idit Maharshak, Mathias W. Seeliger, Tami Livnat, Tamar Kadar, Susanne C. Beck, Shiran Salomon-Zimri

Publikováno v: Current Alzheimer research. 12(4)

Apolipoprotein E4 (apoE4), the most prevalent genetic risk factor for Alzheimer's disease (AD), is associated with neuronal and vascular impairments. Recent findings suggest that retina of apoE4 mice have synaptic and functional impairments. We prese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373fa7553a8f8a9552da70f7f3da7ecb
https://pubmed.ncbi.nlm.nih.gov/25817253