Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Shiran, Shapira"'
Autor:
Ioannis Grigoropoulos, Georgios Tsioulos, Artemis Kastrissianakis, Shiran Shapira, Orr Green, Vasiliki Rapti, Maria Tsakona, Thomas Konstantinos, Athina Savva, Dimitra Kavatha, Dimitrios Boumpas, Konstantinos Syrigos, Ioannis Xynogalas, Konstantinos Leontis, Vasileios Ntousopoulos, Vissaria Sakka, Zafeiris Sardelis, Andreas Fotiadis, Lamprini Vlassi, Chrysoula Kontogianni, Anastasia Levounets, Garyfalia Poulakou, Mina Gaga, Ronan MacLoughlin, Justin Stebbing, Nadir Arber, Anastasia Antoniadou, Sotirios Tsiodras
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Introduction EXO-CD24 are exosomes genetically manipulated to over-express Cluster of Differentiation (CD) 24. It consists of two breakthrough technologies: CD24, the drug, as a novel immunomodulator that is smarter than steroids without any
Externí odkaz:
https://doaj.org/article/24f5adc7c431420c90c68b1ab0f43b4a
Autor:
Shiran Shapira, Marina Ben Shimon, Mori Hay‐Levi, Gil Shenberg, Guy Choshen, Lian Bannon, Michael Tepper, Dina Kazanov, Jonathan Seni, Shahar Lev‐Ari, Michael Peer, Dimitrios Boubas, Justin Stebbing, Sotirios Tsiodras, Nadir Arber
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 9, Pp 1-17 (2022)
Abstract A small but significant proportion of COVID‐19 patients develop life‐threatening cytokine storm. We have developed a new anti‐inflammatory drug, EXO‐CD24, a combination of an immune checkpoint (CD24) and a delivery platform (exosomes
Externí odkaz:
https://doaj.org/article/e8cb646be73748bdab517e8146718ff6
Autor:
Orr Green, Gil Shenberg, Roni Baruch, Lihi Argaman, Talya Levin, Ian Michelson, Ruthy Hadary, Boris Isakovich, Miri Golos, Reut Schwartz, Ronan MacLoughlin, Nimrod Adi, Nadir Arber, Shiran Shapira
Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2523 (2023)
Rationale: Acute respiratory distress syndrome (ARDS) is a major global health concern with a significant unmet need. EXO-CD24 is delivered via inhalation-reduced cytokines and chemokine secretion and lung injury in ARDS and improved survival in mice
Externí odkaz:
https://doaj.org/article/279f02338c0d4c76b4e8338848d39cc4
Autor:
Georgios Tsioulos, Ioannis Grigoropoulos, Charalampos D. Moschopoulos, Shiran Shapira, Garyfallia Poulakou, Anastasia Antoniadou, Dimitrios Boumpas, Nadir Arber, Sotirios Tsiodras
Publikováno v:
Life, Vol 12, Iss 10, p 1472 (2022)
Cluster of differentiation (CD) 24, a long-known protein with multifaceted functions, has gained attention as a possible treatment for Coronavirus Disease 19 (COVID-19) due to its known anti-inflammatory action. Extracellular vesicles (EVs), such as
Externí odkaz:
https://doaj.org/article/47155fe8369b4be4aae3279173ff7222
Publikováno v:
Vaccines, Vol 10, Iss 7, p 1119 (2022)
Some of the most significant medical achievements in recent history are the development of distinct and effective vaccines, and the improvement of the efficacy of previously existing ones, which have contributed to the eradication of many dangerous a
Externí odkaz:
https://doaj.org/article/7b901cd398a64504938afb431accd3f1
Autor:
Ezra Bernstein, Shahar Lev-Ari, Shiran Shapira, Ari Leshno, Udi Sommer, Humaid Al-Shamsi, Meital Shaked, Ori Segal, Lior Galazan, Mori Hay-Levy, Miri Sror, Amira Harlap-Gat, Michael Peer, Menachem Moshkowitz, Ido Wolf, Eliezer Liberman, Gil Shenberg, Eyal Gur, Hanoch Elran, Gustavo Melinger, Jacob Mashiah, Ofer Isakov, Elad Zrifin, Nathan Gluck, Roy Dekel, Shlomi Kleinman, Galit Aviram, Arye Blachar, Ada Kessler, Orit Golan, Ravit Geva, Ofer Yossepowitch, Alfred I. Neugut, Nadir Arber
Publikováno v:
Journal of Clinical Oncology. 41:2503-2510
PURPOSE Cancer is the second leading cause of death globally. However, by implementing evidence-based prevention strategies, 30%-50% of cancers can be detected early with improved outcomes. At the integrated cancer prevention center (ICPC), we aimed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23bec9a8c1fdbc86b0705cb7784bff96
https://doi.org/10.1200/jco.22.00938
https://doi.org/10.1200/jco.22.00938
Autor:
Itai Tzfoni, Jennifer Chayo, Meital Shaked, Ezra Bernstein, Roy Dekel, Nadir Arber, Shiran Shapira
Publikováno v:
SAGE Open Medical Case Reports, Vol 7 (2019)
Bloom syndrome is a rare autosomal recessive disorder characterized by distinct physical features, such as short stature, genomic instability, and predisposition to numerous cancers. The BLM gene encodes for the RecQ helicase that plays an important
Externí odkaz:
https://doaj.org/article/be9627b71b66447098eb9dc161f25778
Autor:
Ioannis Grigoropoulos, Georgios Tsioulos, Artemis Kastrissianakis, Shiran Shapira, Nadir Arber, Garyfallia Poulakou, Konstantinos Syrigos, Vasiliki Rapti, Ioannis Xynogalas, Konstantinos Leontis, Vasileios Ntousopoulos, Vissaria Sakka, Mina Gaga, Zafeiris Sardelis, Andreas Fotiadis, Lamprini Vlassi, Chrysoula Kontogianni, Anastasia Levounets, Maria Tsakona, Athina Savva, Dimitra Kavatha, Dimitrios Boumpas, Anastasia Antoniadou, Sotirios Tsiodras
Publikováno v:
Open Forum Infectious Diseases. 9
Background EXO-CD24 is a novel inhaled drug of exosomes displaying CD24, a protein with anti-inflammatory properties. We evaluated the safety and potential efficacy of EXO-CD24, in a phase II, randomized, single-blinded clinical trial of EXO-CD24 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18d967e4befa8a8f9d4cf7b1907fa704
https://doi.org/10.1093/ofid/ofac492.991
https://doi.org/10.1093/ofid/ofac492.991
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191665 (2018)
To use a micro-computed tomography (micro-CT) to quantify bone healing at maxillary first molar extraction sites, and test the hypothesis that bone healing is impaired in CD24-knockout mice as compared with wild-type C57BL/6J mice.Under ketamine-xyla
Externí odkaz:
https://doaj.org/article/ea5ea9de864a4c11814e4bd48337b790
Autor:
Shiran Shapira, Ari Leshno, Daniel Katz, Nitsan Maharshak, Gil Hevroni, Maayan Jean-David, Sarah Kraus, Lior Galazan, Ilan Aroch, Dina Kazanov, Aharon Hallack, Stewart Becker, Mark Umanski, Menachem Moshkowitz, Iris Dotan, Nadir Arber
Publikováno v:
Therapeutic Advances in Gastroenterology, Vol 11 (2018)
Background: Curcumin, green tea polyphenols and selenium possess anti-inflammatory and anti-oxidant properties. Individually they have demonstrated some efficacy in animal models and human subjects with inflammatory bowel disease (IBD). To evaluate t
Externí odkaz:
https://doaj.org/article/649022788e9d420296be43ccc5f34e48