Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Shira Orr"'
Autor:
Dina Stroopinsky, Jessica Liegel, Manoj Bhasin, Giulia Cheloni, Beena Thomas, Swati Bhasin, Ruchit Panchal, Haider Ghiasuddin, Maryam Rahimian, Myrna Nahas, Shira Orr, Marzia Capelletti, Daniela Torres, Cansu Tacettin, Matthew Weinstock, Lina Bisharat, Adam Morin, Kathleen M. Mahoney, Benjamin Ebert, Richard Stone, Donald Kufe, Gordon J. Freeman, Jacalyn Rosenblatt, David Avigan
Publikováno v:
Haematologica, Vol 106, Iss 5 (2021)
We have developed a personalized vaccine whereby patient derived leukemia cells are fused to autologous dendritic cells, evoking a polyclonal T cell response against shared and neo-antigens. We postulated that the dendritic cell (DC)/AML fusion vacci
Externí odkaz:
https://doaj.org/article/2a6291d314f043b989dfb3f94c54168f
Autor:
Shira, Orr, Ling, Huang, James, Moser, Dina, Stroopinsky, Omar, Gandarilla, Cori, DeCicco, Jessica, Liegel, Cansu, Tacettin, Adam, Ephraim, Giulia, Cheloni, Daniela, Torres, Donald, Kufe, Jacalyn, Rosenblatt, Manuel, Hidalgo, Senthil K, Muthuswamy, David, Avigan
Publikováno v:
Cancer Immunology, Immunotherapy. 72:301-313
Pancreatic cancer is a highly lethal malignancy often presenting with advanced disease and characterized by resistance to standard chemotherapy. Immune-based therapies such checkpoint inhibition have been largely ineffective such that pancreatic canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e097231d91d57f20b0e0294781d6de6
https://doi.org/10.1007/s00262-022-03237-x
https://doi.org/10.1007/s00262-022-03237-x
Autor:
Jacalyn Rosenblatt, Haider Ghiasuddin, Cansu Tacettin, Gordon J. Freeman, Donald Kufe, Manoj Bhasin, Beena E Thomas, Ruchit Panchal, Benjamin L. Ebert, Shira Orr, Dina Stroopinsky, David Avigan, Giulia Cheloni, Richard Stone, Lina Bisharat, Marzia Capelletti, Jessica Liegel, Matthew Weinstock, Maryam Rahimian, Adam Morin, Myrna Nahas, Kathleen M. Mahoney, Daniela Torres, Swati S. Bhasin
Publikováno v:
Haematologica
We have developed a personalized vaccine in which patientderived leukemia cells are fused to autologous dendritic cells, evoking a polyclonal T-cell response against shared antigens and neoantigens. We postulated that the dendritic cell/acute myeloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264127a6496737e21e2eb3843d3adf14
https://doi.org/10.3324/haematol.2020.259457
https://doi.org/10.3324/haematol.2020.259457
Autor:
Hua Chang, Leah Henegar, Christopher J. Walker, Trinayan Kashyap, Marie Maloof, Feng Wang, Kathleen Martyn, Shira Orr, Sharon Tamir, Michael G. Kauffman, Sharon Shacham, Yosef Landesman
Publikováno v:
Cancer Research. 82:5455-5455
Background: Glioblastoma (GBM) is an aggressive brain cancer with poor prognosis and limited treatment options. Selinexor is a first-in-class oral inhibitor of Exportin 1 (XPO1/CRM1) with broad anti-cancer activities and is clinically approved to tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bae542ffb51a7eefc5dc5fc842ca15f7
https://doi.org/10.1158/1538-7445.am2022-5455
https://doi.org/10.1158/1538-7445.am2022-5455
Autor:
Leah Henegar, Hua Chang, Christopher J. Walker, Trinayan Kashyap, Marie Maloof, Feng Wang, Kathleen Martyn, Shira Orr, Sharon Tamir, Michael G. Kauffman, Sharon Shacham, Yosef Landesman
Publikováno v:
Cancer Research. 82:6022-6022
Background: Glioblastoma (GBM) is the most common primary brain tumor with a poor prognosis. It is also one of the most vascularized human tumors. The anti-angiogenesis agent bevacizumab (BEV) is the only US FDA approved agent for recurrent GBM. Give
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db8190124eab86cc5e37bd7e535ffad7
https://doi.org/10.1158/1538-7445.am2022-6022
https://doi.org/10.1158/1538-7445.am2022-6022
Autor:
Hua Chang, Leah Henegar, Christopher J. Walker, Trinayan Kashyap, Marie Maloof, Feng Wang, Kathleen Martyn, Shira Orr, Michael G. Kauffman, Sharon Shacham, Yosef Landesman
Publikováno v:
Cancer Research. 82:5519-5519
Background: Colorectal cancer (CRC) is the second leading cause of cancer related death. In approximately half of all CRC cases, oncogenic KRAS mutations underlie poor prognosis and drug resistance. A previous multi-genomic analysis of 4,725 biologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a86a5ed041c5990844864a89541bbfed
https://doi.org/10.1158/1538-7445.am2022-5519
https://doi.org/10.1158/1538-7445.am2022-5519
Autor:
Leah Henegar, Hua Chang, Christopher J. Walker, Trinayan Kashyap, Marie Maloof, Feng Wang, Kathleen Martyn, Shira Orr, Sharon Tamir, Michael G. Kauffman, Sharon Shacham, Yosef Landesman
Publikováno v:
Cancer Research. 82:6023-6023
Background: The alkylating agent temozolomide (TMZ) is widely applied as an effective first line treatment to glioblastoma (GBM), but its effectiveness is substantially reduced by the MGMT O6-methylguanine-DNA methyltransferase that repairs the main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2661930ce1bc6324e2e43e41813ef59
https://doi.org/10.1158/1538-7445.am2022-6023
https://doi.org/10.1158/1538-7445.am2022-6023
Autor:
Myrna Nahas, Adam Morin, David Avigan, Maryam Rahimian, Shira Orr, Dina Stroopinsky, Haider Ghiasuddin, Michel Sadelain, Marzia Capelletti, Lina Bisharat, Nikhil C. Munshi, Donald Kufe, Gertrude Gunset, Maria Themeli, Jacalyn Rosenblatt, Jessica Liegel, Tuna Mutis, Daniela Torres
Publikováno v:
Biology of Blood and Marrow Transplantation. 26:S42-S43
Introduction CAR T cells have demonstrated unique potency for tumor cytoreduction and durable response in hematological malignancies. However, disease relapse remains a concern due to the emergence of antigen negative variants, tolerization of CAR T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44e65c6d5e9769bb8f070ecd13ed33ba
https://doi.org/10.1016/j.bbmt.2019.12.110
https://doi.org/10.1016/j.bbmt.2019.12.110
Autor:
Jacalyn Rosenblatt, Myrna Nahas, German Pihan, Marzia Capelletti, David Avigan, Adam Morin, Manoj Bhasin, Shira Orr, Dina Stroopinsky, Donald Kufe, Emma Logan, Cansu Tacettin, Beena E Thomas, Jessica Liegel, Lina Bisharat, Haider Ghiassudin, Matthew Weinstock, Maryam Rahimian
Publikováno v:
Biology of Blood and Marrow Transplantation. 26:S13-S14
Introduction In a clinical trial of patients vaccinated after chemotherapy-induced remission with patient-derived AML cells fused with autologous dendritic cells (DC/AML fusions) we demonstrated durable AML-specific immunity. 71% of patients sustaine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd328cd67762cba25b4f0f44c4a39f17
https://doi.org/10.1016/j.bbmt.2019.12.078
https://doi.org/10.1016/j.bbmt.2019.12.078
Autor:
Jeffrey J. Molldrem, Anna Sergeeva, Adam Ephraim, Shira Orr, Dina Stroopinsky, Jessica Liegel, Abigail Washington, Salvia Jain, Myrna Nahas, Matthew Weinstock, Jacalyn Rosenblatt, Leandra Cole, Athalia Rachel Pyzer, Frank J. Slack, Maryam Rahimian, Malgorzata McMasters, David Avigan, Rebecca Karp Leaf, Eleni Anastasiadou, Haider Ghiasuddin, Donald Kufe
Acute myeloid leukaemia (AML) is a lethal haematological malignancy characterized by an immunosuppressive milieu in the tumour microenvironment (TME) that fosters disease growth and therapeutic resistance. Hypomethylating agents (HMAs) demonstrate cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad49eebc165fd4558de8a5798a99170
http://hdl.handle.net/11573/1256900
http://hdl.handle.net/11573/1256900
