Výsledky vyhledávání - "Shira, Elhyany"

Targeting lipid rafts inhibits protein kinase B by disrupting calcium homeostasis and attenuates malignant properties of melanoma cells

Autor: Daniel Fishman, Michal Hershfinkel, Israel Sekler, Shira Elhyany, Shlomit Fedida-Metula, Sylvia Tsory, Shraga Segal

Publikováno v: Carcinogenesis. 29:1546-1554

Failure of current therapeutic modalities to treat melanoma remains a challenge for clinical and experimental oncology. The aggressive growth and apoptotic resistance of this tumor are mediated, in part, by aberrantly activated protein kinase B/Akt (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74af36c513c666d21423aef1a09c352e
https://doi.org/10.1093/carcin/bgn146

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Alterations in the Expression of MHC Class I Glycoproteins by B16BL6 Melanoma Cells Modulate Insulin Receptor-Regulated Signal Transduction and Augments Resistance to Apoptosis

Autor: Shira Elhyany, Efrat Assa-Kunik, Shraga Segal, Ofer Baharir, Sylvia Tsory, Daniel Fishman, Sigal Kellman-Pressman

Publikováno v: The Journal of Immunology. 171:2945-2952

In a variety of malignancies, the immune-escape phenotype is associated, in part, with the inability of tumor cells to properly present their Ags to CTLs due to a deranged expression of MHC class I glycoproteins. However, these molecules were found t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0b3cc789c4431ed843ccca8b5f5ad68
https://doi.org/10.4049/jimmunol.171.6.2945

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The integrity of cholesterol-enriched microdomains is essential for the constitutive high activity of protein kinase B in tumour cells

Autor: Shraga Segal, Sylvia Tsory, T. Muller, Efrat Assa-Kunik, Shira Elhyany, S. Fedida, Daniel Fishman

Publikováno v: Biochemical Society Transactions. 32:837-839

A deregulated activity of PKB/Akt (where PKB stands for protein kinase B) renders tumour cells resistant to a variety of apoptosis-inducing stimuli. Elucidation of the mechanisms responsible for this deregulation is of prime importance for the develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac767054083353631e46be718d3d36ac
https://doi.org/10.1042/bst0320837

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