Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Shir Toubiana"'
Publikováno v:
Journal of Dermatological Treatment, Vol 35, Iss 1 (2024)
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. Most patients with moderate-to-severe disease require long-term antibiotic treatment, or biologic treatments to control their disease. Despite these interventions, rela
Externí odkaz:
https://doaj.org/article/e509f0c7989943ed8cd657f8b069626b
Autor:
Liat H. Hartal-Benishay, Esraa Saadi, Shir Toubiana, Lior Shaked, Maya Lalzar, Ossama Abu Hatoum, Sharon Tal, Sara Selig, Liza Barki-Harrington
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Among the main metabolic pathways implicated in cancer cell proliferation are those of cholesterol and fatty acid synthesis, both of which are tightly regulated by sterol regulatory element-binding proteins (SREBPs). SREBPs are activated through spec
Externí odkaz:
https://doaj.org/article/683c88f5eac9466e83038593963da76e
Autor:
Shira Sagie, Shir Toubiana, Stella R. Hartono, Hagar Katzir, Aya Tzur-Gilat, Shany Havazelet, Claire Francastel, Guillaume Velasco, Frédéric Chédin, Sara Selig
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
ICF syndrome cells exhibit shortened telomeres and elevated levels of the noncoding RNA TERRA. Here the authors show this is associated with high levels of DNA damage, suggesting an increase in telomere dysfunction due to the formation of DNA: RNA hy
Externí odkaz:
https://doaj.org/article/a6ea7685f09c4013935240ad88a3e9f7
Autor:
Shir Toubiana, Miriam Gagliardi, Mariarosaria Papa, Roberta Manco, Maty Tzukerman, Maria R Matarazzo, Sara Selig
Publikováno v:
eLife, Vol 8 (2019)
DNA methyltransferase 3B (DNMT3B) is the major DNMT that methylates mammalian genomes during early development. Mutations in human DNMT3B disrupt genome-wide DNA methylation patterns and result in ICF syndrome type 1 (ICF1). To study whether normal D
Externí odkaz:
https://doaj.org/article/f01eb2a545ed43209924dc93efd966ed
Publikováno v:
Life, Vol 11, Iss 4, p 278 (2021)
Most human cancers circumvent senescence by activating a telomere length maintenance mechanism, most commonly involving telomerase activation. A minority of cancers utilize the recombination-based alternative lengthening of telomeres (ALT) pathway. T
Externí odkaz:
https://doaj.org/article/9ca423048e9a4dafae68936432173cf5
Autor:
Varsha Poondi Krishnan, Barbara Morone, Shir Toubiana, Monika Krzak, Salvatore Fioriniello, Floriana Della Ragione, Maria Strazzullo, Claudia Angelini, Sara Selig, Maria R. Matarazzo
Publikováno v:
Genome Research. 33:169-183
Bi-allelic hypomorphic mutations inDNMT3Bdisrupt DNA methyltransferase activity and lead to immunodeficiency, centromeric instability, facial anomalies syndrome, type 1 (ICF1). Although several ICF1 phenotypes have been linked to abnormally hypomethy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24b5f2a775e178a279dac73095873117
https://doi.org/10.1101/gr.276986.122
https://doi.org/10.1101/gr.276986.122
Autor:
John Z. Cao, Chen Itzkovich, Shir Toubiana, Lucy A. Godley, Adi Mory, Kamal Abu Jabal, Nadra Samra, Liran Giladi, Hagit Baris Feldman, Kristian Tveten, Hilde Yttervik, Sara Selig, Karin Weiss, Ilham Morani, Aya Tzur-Gilat
Publikováno v:
Journal of Human Genetics. 66:1101-1112
RBL2/p130, a member of the retinoblastoma family of proteins, is a key regulator of cell division and propagates irreversible senescence. RBL2/p130 is also involved in neuronal differentiation and survival, and eliminating Rbl2 in certain mouse strai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9e1c0ddb84341a35ad0890ddb060f9d
https://doi.org/10.1038/s10038-021-00931-z
https://doi.org/10.1038/s10038-021-00931-z
Autor:
Varsha Poondi Krishnan, Barbara Morone, Shir Toubiana, Monika Krzak, Maria Strazzullo, Claudia Angelini, Sara Selig, Maria R. Matarazzo
BackgroundBi-allelic hypomorphic mutations in DNMT3B disrupt DNA methyltransferase activity and lead to Immunodeficiency, Centromeric instability, Facial anomalies syndrome, type 1 (ICF1). While several ICF1 phenotypes have been linked to abnormally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ac89b1b46d190aef182d942c0089da8
https://doi.org/10.1101/2022.05.07.491011
https://doi.org/10.1101/2022.05.07.491011
Autor:
Claire Francastel, Riham Smoom, Lucy A. Godley, Guillaume Velasco, Sara Selig, Gal Larom, Shir Toubiana, Robert Duszynski
Publikováno v:
Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2020, 29 (19), pp.3197-3210. ⟨10.1093/hmg/ddaa206⟩
Human Molecular Genetics, Oxford University Press (OUP), 2020, 29 (19), pp.3197-3210. ⟨10.1093/hmg/ddaa206⟩
The most distal 2 kb region in the majority of human subtelomeres contains CpG-rich promoters for TERRA, a long non-coding RNA. When the function of the de novo DNA methyltransferase DNMT3B is disrupted, as in ICF1 syndrome, subtelomeres are abnormal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7046a794f3286d57635f717f6d631397
https://doi.org/10.1093/hmg/ddaa206
https://doi.org/10.1093/hmg/ddaa206
Publikováno v:
Life, Vol 11, Iss 278, p 278 (2021)
Life
Volume 11
Issue 4
Life
Volume 11
Issue 4
Most human cancers circumvent senescence by activating a telomere length maintenance mechanism, most commonly involving telomerase activation. A minority of cancers utilize the recombination-based alternative lengthening of telomeres (ALT) pathway. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2786d6195fca3958d74e157ad0905adb
https://www.mdpi.com/2075-1729/11/4/278
https://www.mdpi.com/2075-1729/11/4/278