Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Shir Marciano"'
Variant-proof high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airways
Autor:
Matthew Gagne, Barbara J. Flynn, Christopher Cole Honeycutt, Dillon R. Flebbe, Shayne F. Andrew, Samantha J. Provost, Lauren McCormick, Alex Van Ry, Elizabeth McCarthy, John-Paul M. Todd, Saran Bao, I-Ting Teng, Shir Marciano, Yinon Rudich, Chunlin Li, Shilpi Jain, Bushra Wali, Laurent Pessaint, Alan Dodson, Anthony Cook, Mark G. Lewis, Hanne Andersen, Jiří Zahradník, Mehul S. Suthar, Martha C. Nason, Kathryn E. Foulds, Peter D. Kwong, Mario Roederer, Gideon Schreiber, Robert A. Seder, Daniel C. Douek
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract SARS-CoV-2 has the capacity to evolve mutations that escape vaccine- and infection-acquired immunity and antiviral drugs. A variant-agnostic therapeutic agent that protects against severe disease without putting selective pressure on the vir
Externí odkaz:
https://doaj.org/article/398a2dfd9ac6483f881f1a81f6f17840
Autor:
Justin T. Seffernick, SM Bargeen Alam Turzo, Sophie R. Harvey, Yongseok Kim, Árpád Somogyi, Shir Marciano, Vicki H. Wysocki, Steffen Lindert
Publikováno v:
Analytical chemistry. 94(29)
Understanding the relationship between protein structure and experimental data is crucial for utilizing experiments to solve biochemical problems and optimizing the use of sparse experimental data for structural interpretation. Tandem mass spectromet
Autor:
Debabrata Dey, Shir Marciano, Anna Poryvai, Ondřej Groborz, Lucie Wohlrábová, Tomás Slanina, Gideon Schreiber
Drug efficacy depends not only on delivery but also on intracellular diffusion, distribution and availability. Yet, more than a half of pharmaceutical drugs are weakly basic and thus, protonated and sequestered at intracellular pH. Protonation reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f368b1e01da5e32e9fd320af212571ea
https://doi.org/10.1101/2023.04.19.537456
https://doi.org/10.1101/2023.04.19.537456
Autor:
Chloé I. Charendoff, Agathe Subtil, Shir Marciano, Debabrata Dey, Jiří Zahradník, Gideon Schreiber, Lucie Kolářová
Publikováno v:
ACS Synthetic Biology
ACS Synthetic Biology, 2021, 10 (12), pp.3445-3460. ⟨10.1021/acssynbio.1c00395⟩
ACS Synthetic Biology, 2021, 10 (12), pp.3445-3460. ⟨10.1021/acssynbio.1c00395⟩
International audience; Here, we enhanced the popular yeast display method by multiple rounds of DNA and protein engineering. We introduced surface exposure-tailored reporters, eUnaG2 and DnbALFA, creating a new platform of C and N terminal fusion ve
Autor:
Timothy N. Hoang, Elise G. Viox, Amit A. Upadhyay, Zachary Strongin, Gregory K. Tharp, Maria Pino, Rayhane Nchioua, Maximilian Hirschenberger, Matthew Gagne, Kevin Nguyen, Justin L. Harper, Shir Marciano, Arun K. Boddapati, Kathryn L. Pellegrini, Jennifer Tisoncik-Go, Leanne S. Whitmore, Kirti A. Karunakaran, Melissa Roy, Shannon Kirejczyk, Elizabeth H. Curran, Chelsea Wallace, Jennifer S. Wood, Fawn Connor-Stroud, Sudhir P. Kasturi, Rebecca D. Levit, Michael Gale, Thomas H. Vanderford, Guido Silvestri, Kathleen Busman-Sahay, Jacob D. Estes, Monica Vaccari, Daniel C. Douek, Konstantin M.J. Sparrer, Frank Kirchhoff, R. Paul Johnson, Gideon Schreiber, Steven E. Bosinger, Mirko Paiardini
Type-I interferons (IFN-I) are critical mediators of innate control of viral infections, but also drive recruitment of inflammatory cells to sites of infection, a key feature of severe COVID-19. Here, and for the first time, IFN-I signaling was modul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98becb0535e8b6bb904a81ed8536fc97
https://doi.org/10.1101/2022.10.21.512606
https://doi.org/10.1101/2022.10.21.512606
Autor:
Shir Marciano, Debabrata Dey, Dina Listov, Sarel J Fleishman, Adar Sonn-Segev, Haydyn Mertens, Florian Busch, Yongseok Kim, Sophie R. Harvey, Vicki H. Wysocki, Gideon Schreiber
Publikováno v:
Chemical science 13(39), 11680-11695 (2022). doi:10.1039/D2SC02794A
Chemical science 13(39), 11680 - 11695 (2022). doi:10.1039/D2SC02794A
Over half the proteins in the E. coli cytoplasm form homo or hetero-oligomeric structures. Experimentally determined structures are often considered in determining a protein's
Over half the proteins in the E. coli cytoplasm form homo or hetero-oligomeric structures. Experimentally determined structures are often considered in determining a protein's
Autor:
Justin Seffernick, SM Bargeen Turzo, Sophie Harvey, Yongseok Kim, Árpád Somogyi, Shir Marciano, Vicki Wysocki, Steffen Lindert
Understanding the relationship between protein structure and experimental data is crucial for utilizing experiments to solve biochemical problems and optimizing the use of sparse experimental data for structural interpretation. Tandem mass spectromet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b66cf5db8c8723886163847b1b1dd02f
https://doi.org/10.26434/chemrxiv-2022-75cjp
https://doi.org/10.26434/chemrxiv-2022-75cjp
Autor:
Maya Shemesh, Daniel Harari, Daniel C. Douek, Eyal Zoler, Yinon Rudich, Jeanne Chiaravalli, Orly Dym, Jiří Zahradník, Ira Marton, Hanne Leth Andersen, Chunlin Li, Robert A. Seder, Matthew Gagne, Mark G. Lewis, Bjorn Meyer, Gideon Schreiber, Nadav Elad, Shir Marciano
Publikováno v:
Nature Microbiology
Nature Microbiology, Nature Publishing Group, 2021, ⟨10.1038/s41564-021-00954-4⟩
Nature Microbiology, 2021, ⟨10.1038/s41564-021-00954-4⟩
Nature Microbiology, Nature Publishing Group, 2021, ⟨10.1038/s41564-021-00954-4⟩
Nature Microbiology, 2021, ⟨10.1038/s41564-021-00954-4⟩
SARS-CoV-2 variants of interest and concern will continue to emerge for the duration of the COVID-19 pandemic. To map mutations in the receptor-binding domain (RBD) of the spike protein that affect binding to angiotensin-converting enzyme 2 (ACE2), t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832d3f3b2cfa486cd2a9f41e44e53a76
https://hal-pasteur.archives-ouvertes.fr/pasteur-03321160
https://hal-pasteur.archives-ouvertes.fr/pasteur-03321160
Autor:
Yinon Rudich, Nadav Elad, Gideon Schreiber, Eyal Zoler, Maya Shemesh, Jeanne Chiaravalli, Orly Dym, Bjoern Meyer, Shir Marciano, Jiri Zahradnik
SARS-CoV-2 is continually evolving, with more contagious mutations spreading rapidly. Using in vitro evolution to affinity maturate the receptor-binding domain (RBD) of the spike protein towards ACE2 resulted in the more contagious mutations, S477N,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c16394ef072c761f9bc9d7fbe43e181
https://doi.org/10.21203/rs.3.rs-183310/v1
https://doi.org/10.21203/rs.3.rs-183310/v1
Autor:
Ariane Nunes-Alves, Gideon Schreiber, Vladimir Kiss, Rebecca C. Wade, Shir Marciano, Debabrata Dey
Publikováno v:
Journal of molecular biology. 433(9)
The crowded cellular milieu affect molecular diffusion through hard (occluded space) and soft (weak, non-specific) interactions. Multiple methods have been developed to measure diffusion coefficients at physiological protein concentrations within cel