Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Shiqin Miao"'
Autor:
Yufeng Liang, Sydney Willey, Yu-Chieh Chung, Yi-Meng Lo, Shiqin Miao, Sarah Rundell, Li-Chun Tu, Dennis Bong
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The most widely used method for intracellular RNA fluorescence labeling is MS2 labeling, which generally relies on the use of multiple protein labels targeted to multiple RNA (MS2) hairpin structures installed on the RNA of interest (ROI). W
Externí odkaz:
https://doaj.org/article/23e79c6a5d6d4539bf3d5cdefb068e68
Autor:
Yufeng Liang, Sydney Willey, Yu-Chieh Chung, Yi-Meng Lo, Shiqin Miao, Sarah Rundell, Li-Chun Tu, Dennis Bong
We introduce herein a new strategy for intracellular RNA and DNA tracking that is robust, orthogonal and complementary to existing methods: Fluorogenic U-Rich Internal Loop (FLURIL) tagging with cell-permeable fluorophore-labeled bifacial Peptide Nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::088d84998e8a35a6d6fc7514b6f6081d
https://doi.org/10.1101/2022.07.21.501035
https://doi.org/10.1101/2022.07.21.501035
Publikováno v:
Chemistry
We hypothesize that programmable hybridization to noncanonical nucleic acid motifs may be achieved by macromolecular display of binders to individual noncanonical pairs (NCPs). As each recognition element may individually have weak binding to an NCP,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3f7ba99191c86cfd57b43e742141d9
https://doi.org/10.1002/chem.202103616
https://doi.org/10.1002/chem.202103616
Autor:
Shiqin Miao, Debmalya Bhunia, Dennis Bong, Yufeng Liang, Sarah Rundell, Oliver Munyaradzi, Shekaraiah Devari
Publikováno v:
ACS Chem Biol
We report herein a new class of synthetic reagents for targeting the element for nuclear expression (ENE) in MALAT1, a long noncoding RNA upregulated in many cancers. The cis-acting ENE contains a U-rich internal loop (URIL) that forms an 11 base UAU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e5852085cea4dc28e00dd4b1bfcdec
https://pubmed.ncbi.nlm.nih.gov/34382766
https://pubmed.ncbi.nlm.nih.gov/34382766
Autor:
Dennis Bong, Shekar Devari, Yufeng Liang, Debmalya Bhunia, Oliver Munyaradzi, Shiqin Miao, Sarah Rundell
Publikováno v:
Biopolymers. 112
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ead19e1b214afb3d68d8fb076ffc53c5
https://doi.org/10.1002/bip.23467
https://doi.org/10.1002/bip.23467
Publikováno v:
Journal of the American Chemical Society. 141:9365-9372
We report herein the synthesis and DNA/RNA binding properties of bPNA+, a new variant of bifacial peptide nucleic acid (bPNA) that binds oligo T/U nucleic acids to form triplex hybrids. By virtue of a new bivalent side chain on bPNA+, similar DNA aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd374f7bf1df9568aa11aaea1fdb1811
https://doi.org/10.1021/jacs.9b03435
https://doi.org/10.1021/jacs.9b03435
Autor:
Debmalya Bhunia, Dennis Bong, Shekar Devari, Yufeng Liang, Sarah Rundell, Shiqin Miao, Oliver Munyaradzi
Publikováno v:
Biopolymers
The notion of using synthetic heterocycles instead of the native bases to interface with DNA and RNA has been explored for nearly 60 years. Unnatural bases compatible with the DNA/RNA coding interface have the potential to expand the genetic code and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d977e8da6d782c023b219ae325b3472
https://doi.org/10.1002/bip.23399
https://doi.org/10.1002/bip.23399
Publikováno v:
Biochemistry
Herein, we demonstrate context-dependent molecular recognition of DNA by synthetic bPNA iron and copper complexes, using oxidative backbone cleavage as a chemical readout for binding. Oligoethylenimine bPNAs displaying iron·EDTA or copper·phenanthr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db984b19cd1359fc06f1a8eb4c00f467
https://pubmed.ncbi.nlm.nih.gov/32519542
https://pubmed.ncbi.nlm.nih.gov/32519542
Autor:
Ashley Buchanan, Jesse J. McClure, Shiqin Miao, Yuri K. Peterson, Kalyan Chundru, Bradley Lee, Cheng Zhang, C. James Chou, Jiaying Li, Elizabeth S. Inks
Publikováno v:
ACS Chemical Biology. 12:1644-1655
The acetylation status of lysine residues on histone proteins has long been attributed to a balance struck between the catalytic activity of histone acetyl transferases and histone deacetylases (HDAC). HDACs were identified as the sole removers of ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50311bdf007f48f64d290a7c4fe2891d
https://doi.org/10.1021/acschembio.7b00321
https://doi.org/10.1021/acschembio.7b00321
We report herein the synthesis and DNA/RNA binding properties of bPNA+, a new variant of bifacial peptide nucleic acid (bPNA) that binds oligo T/U nucleic acids to form triplex hybrids. By virtue of a new bivalent sidechain on bPNA+, similar DNA affi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ad25a7b1ac8559e5521eae03d45f1f
https://doi.org/10.26434/chemrxiv.7583624
https://doi.org/10.26434/chemrxiv.7583624