BH3-mimetics or DNA-damaging agents in combination with RG7388 overcome p53 mutation-induced resistance to MDM2 inhibition.

Autor: Pervushin NV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.; Faculty of Medicine, MV Lomonosov Moscow State University, Moscow, 119991, Russia., Nilov DK; Belozersky Institute of Physicochemical Biology, Lomonosov Moscow State University, Moscow, 119991, Russia., Pushkarev SV; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, 119234, Russia., Shipunova VO; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.; Moscow Center for Advanced Studies, Moscow, 123592, Russia., Badlaeva AS; Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Russian Ministry of Health, Moscow, 117513, Russia., Yapryntseva MA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.; Faculty of Medicine, MV Lomonosov Moscow State University, Moscow, 119991, Russia., Kopytova DV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia., Zhivotovsky B; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia. Boris.Zhivotovsky@ki.se.; Faculty of Medicine, MV Lomonosov Moscow State University, Moscow, 119991, Russia. Boris.Zhivotovsky@ki.se.; Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, 17177, Stockholm, Sweden. Boris.Zhivotovsky@ki.se., Kopeina GS; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia. lirroster@gmail.com.; Faculty of Medicine, MV Lomonosov Moscow State University, Moscow, 119991, Russia. lirroster@gmail.com.

Publikováno v: Apoptosis : an international journal on programmed cell death [Apoptosis] 2024 Dec; Vol. 29 (11-12), pp. 2197-2213. Date of Electronic Publication: 2024 Sep 02.

Albumin incorporation into recognising layer of HER2-specific magnetic nanoparticles as a tool for optimal targeting of the acidic tumor microenvironment.

Autor: Kolesnikova OA; Moscow Center for Advanced Studies, Kulakova str. 20, 123592, Moscow, Russia., Komedchikova EN; Moscow Center for Advanced Studies, Kulakova str. 20, 123592, Moscow, Russia.; Moscow Institute of Physics and Technology, 9 Institutskiy Per., 141701, Dolgoprudny, Russia., Zvereva SD; Moscow Center for Advanced Studies, Kulakova str. 20, 123592, Moscow, Russia.; Moscow Institute of Physics and Technology, 9 Institutskiy Per., 141701, Dolgoprudny, Russia., Obozina AS; Moscow Center for Advanced Studies, Kulakova str. 20, 123592, Moscow, Russia., Dorozh OV; Moscow Center for Advanced Studies, Kulakova str. 20, 123592, Moscow, Russia., Afanasev I; Moscow Center for Advanced Studies, Kulakova str. 20, 123592, Moscow, Russia.; Moscow Institute of Physics and Technology, 9 Institutskiy Per., 141701, Dolgoprudny, Russia., Nikitin PI; Prokhorov General Physics Institute, Russian Academy of Sciences, 38 Vavilov Street, 119991, Moscow, Russia., Mochalova EN; Moscow Center for Advanced Studies, Kulakova str. 20, 123592, Moscow, Russia.; Department of Nanobiomedicine, Sirius University of Science and Technology, 1 Olympic Ave., 354340, Sochi, Russia.; Moscow Institute of Physics and Technology, 9 Institutskiy Per., 141701, Dolgoprudny, Russia., Nikitin MP; Moscow Center for Advanced Studies, Kulakova str. 20, 123592, Moscow, Russia.; Department of Nanobiomedicine, Sirius University of Science and Technology, 1 Olympic Ave., 354340, Sochi, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997, Moscow, Russia., Shipunova VO; Moscow Center for Advanced Studies, Kulakova str. 20, 123592, Moscow, Russia.; Department of Nanobiomedicine, Sirius University of Science and Technology, 1 Olympic Ave., 354340, Sochi, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997, Moscow, Russia.

Publikováno v: Heliyon [Heliyon] 2024 Jul 06; Vol. 10 (14), pp. e34211. Date of Electronic Publication: 2024 Jul 06 (Print Publication: 2024).

Targeted PLGA-Chitosan Nanoparticles for NIR-Triggered Phototherapy and Imaging of HER2-Positive Tumors.

Autor: Kotelnikova PA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997 Moscow, Russia., Shipunova VO; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997 Moscow, Russia.; Moscow Institute of Physics and Technology, 9 Institutskiy Per., 141701 Dolgoprudny, Russia.; Nanobiomedicine Division, Sirius University of Science and Technology, 1 Olympic Ave., 354340 Sochi, Russia., Deyev SM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997 Moscow, Russia.; Bionanophotonics Laboratory, Institute of Engineering Physics for Biomedicine (PhysBio), National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Kashirskoe Shosse 31, 115409 Moscow, Russia.; Institute of Molecular Theranostics, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.

Publikováno v: Pharmaceutics [Pharmaceutics] 2023 Dec 20; Vol. 16 (1). Date of Electronic Publication: 2023 Dec 20.

Selective targeting of α7 nicotinic acetylcholine receptor by synthetic peptide mimicking loop I of human SLURP-1 provides efficient and prolonged therapy of epidermoid carcinoma in vivo .

Autor: Shlepova OV; NTI Center, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.; Moscow Institute of Physics and Technology, National Research University, Dolgoprudny, Russia., Shulepko MA; Faculty of Biology, Shenzhen MSU-BIT University, Shenzhen, China., Shipunova VO; Moscow Institute of Physics and Technology, National Research University, Dolgoprudny, Russia.; Immunology Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia., Bychkov ML; NTI Center, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia., Kukushkin ID; Moscow Institute of Physics and Technology, National Research University, Dolgoprudny, Russia.; Bioengineering Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia., Chulina IA; Branch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Pushchino, Russia., Azev VN; Branch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Pushchino, Russia., Shramova EI; Immunology Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia., Kazakov VA; Branch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Pushchino, Russia., Ismailova AM; Branch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Pushchino, Russia., Palikova YA; Branch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Pushchino, Russia., Palikov VA; Branch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Pushchino, Russia., Kalabina EA; Branch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Pushchino, Russia., Shaykhutdinova EA; Branch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Pushchino, Russia., Slashcheva GA; Branch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Pushchino, Russia., Tukhovskaya EA; Branch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Pushchino, Russia., Dyachenko IA; Branch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Pushchino, Russia., Murashev AN; Branch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Pushchino, Russia., Deyev SM; Immunology Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.; Biomarker Research Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.; Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Kirpichnikov MP; Bioengineering Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.; Interdisciplinary Scientific and Educational School of Moscow University Molecular Technologies of the Living Systems and Synthetic Biology, Faculty of Biology, Lomonosov Moscow State University, Leninskie Gory, Moscow, Russia., Shenkarev ZO; NTI Center, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.; Moscow Institute of Physics and Technology, National Research University, Dolgoprudny, Russia.; Structural Biology Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia., Lyukmanova EN; Faculty of Biology, Shenzhen MSU-BIT University, Shenzhen, China.; Bioengineering Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.; Interdisciplinary Scientific and Educational School of Moscow University Molecular Technologies of the Living Systems and Synthetic Biology, Faculty of Biology, Lomonosov Moscow State University, Leninskie Gory, Moscow, Russia.

Publikováno v: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2023 Oct 03; Vol. 11, pp. 1256716. Date of Electronic Publication: 2023 Oct 03 (Print Publication: 2023).

Comparative Study of Nanoparticle Blood Circulation after Forced Clearance of Own Erythrocytes (Mononuclear Phagocyte System-Cytoblockade) or Administration of Cytotoxic Doxorubicin- or Clodronate-Loaded Liposomes.

Autor: Mochalova EN; Nanobiomedicine Division, Sirius University of Science and Technology, 1 Olimpiyskiy Ave, 354340 Sirius, Russia.; Moscow Institute of Physics and Technology, 1A Kerchenskaya St., 117303 Moscow, Russia.; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilov St., 119991 Moscow, Russia., Egorova EA; Nanobiomedicine Division, Sirius University of Science and Technology, 1 Olimpiyskiy Ave, 354340 Sirius, Russia., Komarova KS; Moscow Institute of Physics and Technology, 1A Kerchenskaya St., 117303 Moscow, Russia., Shipunova VO; Nanobiomedicine Division, Sirius University of Science and Technology, 1 Olimpiyskiy Ave, 354340 Sirius, Russia.; Moscow Institute of Physics and Technology, 1A Kerchenskaya St., 117303 Moscow, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997 Moscow, Russia., Khabibullina NF; Moscow Institute of Physics and Technology, 1A Kerchenskaya St., 117303 Moscow, Russia., Nikitin PI; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilov St., 119991 Moscow, Russia., Nikitin MP; Nanobiomedicine Division, Sirius University of Science and Technology, 1 Olimpiyskiy Ave, 354340 Sirius, Russia.; Moscow Institute of Physics and Technology, 1A Kerchenskaya St., 117303 Moscow, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997 Moscow, Russia.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Jun 25; Vol. 24 (13). Date of Electronic Publication: 2023 Jun 25.