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pro vyhledávání: '"Shipton, ML"'
The antifungal drug itraconazole has been repurposed to anti-angiogenic agent, but the mechanisms of action have been elusive. Here we report that itraconazole disrupts focal adhesion dynamics and cytoskeletal remodeling, which requires 5-diphosphoin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1064::da6523c3b60e16be773251c10e7cb60d
https://doi.org/10.1016/j.biopha.2023.114449
https://doi.org/10.1016/j.biopha.2023.114449
Autor:
Fu L; Tianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, China., Du J; Tianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, China., Furkert D; Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany., Shipton ML; Medicinal Chemistry and Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK., Liu X; Tianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, China., Aguirre T; Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany., Chin AC; Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA., Riley AM; Medicinal Chemistry and Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK., Potter BVL; Medicinal Chemistry and Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK., Fiedler D; Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany., Zhang X; Tianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, China., Zhu Y; Tianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, China., Fu C; Tianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, China.; Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China.
Publikováno v:
Cardiovascular research [Cardiovasc Res] 2024 Jul 02; Vol. 120 (8), pp. 954-970.
Autor:
Márquez-Moñino MÁ; Department of Crystallography and Structural Biology, Institute of Physical-Chemistry Blas Cabrera, CSIC, Serrano 119, 28006, Madrid, Spain., Ortega-García R; Department of Crystallography and Structural Biology, Institute of Physical-Chemistry Blas Cabrera, CSIC, Serrano 119, 28006, Madrid, Spain., Whitfield H; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK., Riley AM; Drug Discovery and Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK., Infantes L; Department of Crystallography and Structural Biology, Institute of Physical-Chemistry Blas Cabrera, CSIC, Serrano 119, 28006, Madrid, Spain., Garrett SW; Wolfson Laboratory of Medicinal Chemistry, Department of Life Sciences, University of Bath, Claverton Down, Bath, BA2 7AY, UK., Shipton ML; Drug Discovery and Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK., Brearley CA; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK., Potter BVL; Drug Discovery and Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK. barry.potter@pharm.ox.ac.uk.; Wolfson Laboratory of Medicinal Chemistry, Department of Life Sciences, University of Bath, Claverton Down, Bath, BA2 7AY, UK. barry.potter@pharm.ox.ac.uk., González B; Department of Crystallography and Structural Biology, Institute of Physical-Chemistry Blas Cabrera, CSIC, Serrano 119, 28006, Madrid, Spain. xbeatriz@iqf.csic.es.
Publikováno v:
Nature communications [Nat Commun] 2024 Feb 19; Vol. 15 (1), pp. 1502. Date of Electronic Publication: 2024 Feb 19.
Autor:
Whitfield HL; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K., Rodriguez RF; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K.; School of Chemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K., Shipton ML; Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K., Li AWH; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K.; School of Chemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K., Riley AM; Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K., Potter BVL; Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K., Hemmings AM; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K.; School of Chemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K.; College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China., Brearley CA; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K.
Publikováno v:
Biochemistry [Biochemistry] 2024 Jan 02; Vol. 63 (1), pp. 42-52. Date of Electronic Publication: 2023 Dec 26.
Autor:
Shipton ML; Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford Mansfield Road Oxford OX1 3QT UK barry.potter@pharm.ox.ac.uk., Jamion FA; Department of Chemistry, Loughborough University Epinal Way, Loughborough LE11 3TU UK S.J.Butler@lboro.ac.uk., Wheeler S; Department of Chemistry, Loughborough University Epinal Way, Loughborough LE11 3TU UK S.J.Butler@lboro.ac.uk., Riley AM; Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford Mansfield Road Oxford OX1 3QT UK barry.potter@pharm.ox.ac.uk., Plasser F; Department of Chemistry, Loughborough University Epinal Way, Loughborough LE11 3TU UK S.J.Butler@lboro.ac.uk., Potter BVL; Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford Mansfield Road Oxford OX1 3QT UK barry.potter@pharm.ox.ac.uk., Butler SJ; Department of Chemistry, Loughborough University Epinal Way, Loughborough LE11 3TU UK S.J.Butler@lboro.ac.uk.
Publikováno v:
Chemical science [Chem Sci] 2023 Apr 13; Vol. 14 (19), pp. 4979-4985. Date of Electronic Publication: 2023 Apr 13 (Print Publication: 2023).
Autor:
Márquez-Moñino MÁ; Department of Crystallography and Structural Biology, Institute of Physical-Chemistry Rocasolano, CSIC, Serrano 119, 28006 Madrid, Spain., Ortega-García R; Department of Crystallography and Structural Biology, Institute of Physical-Chemistry Rocasolano, CSIC, Serrano 119, 28006 Madrid, Spain., Shipton ML; Drug Discovery and Medicinal Chemistry, Department of Pharmacology, University of Oxford Mansfield Road, Oxford OX1 3QT, UK., Franco-Echevarría E; Department of Crystallography and Structural Biology, Institute of Physical-Chemistry Rocasolano, CSIC, Serrano 119, 28006 Madrid, Spain., Riley AM; Drug Discovery and Medicinal Chemistry, Department of Pharmacology, University of Oxford Mansfield Road, Oxford OX1 3QT, UK., Sanz-Aparicio J; Department of Crystallography and Structural Biology, Institute of Physical-Chemistry Rocasolano, CSIC, Serrano 119, 28006 Madrid, Spain., Potter BVL; Drug Discovery and Medicinal Chemistry, Department of Pharmacology, University of Oxford Mansfield Road, Oxford OX1 3QT, UK., González B; Department of Crystallography and Structural Biology, Institute of Physical-Chemistry Rocasolano, CSIC, Serrano 119, 28006 Madrid, Spain. xbeatriz@iqfr.csic.es.
Publikováno v:
Science advances [Sci Adv] 2021 Apr 23; Vol. 7 (17). Date of Electronic Publication: 2021 Apr 23 (Print Publication: 2021).
Autor:
Shipton ML; Drug Discovery & Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U. K., Riley AM; Drug Discovery & Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U. K., Rossi AM; Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U. K., Brearley CA; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U. K., Taylor CW; Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U. K., Potter BVL; Drug Discovery & Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U. K.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2020 May 28; Vol. 63 (10), pp. 5442-5457. Date of Electronic Publication: 2020 May 06.