Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand and can function as a paracrine survival factor for human myeloma cells

Autor: Shipman, C. M., Peter Croucher

Publikováno v: Scopus-Elsevier
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Myeloma cells grow only in the bone marrow closely associated with bone,suggesting that this microenvironment provides critical signals for their growth and survival. Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF) receptor famil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::898a28ab8e81a57863ffe656dcc3d5b7
https://ora.ox.ac.uk/objects/uuid:9ba52c91-91ba-4de7-b38b-6d4e7e8879bb

The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway

Autor: Shipman, C. M., Peter Croucher, Russell, R. G. G., Helfrich, M. H., Rogers, M. J.

Publikováno v: Scopus-Elsevier
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It has recently been suggested that bisphosphonates may have direct antitumor effects in vivo, in addition to their therapeutic antiresorptive properties. Bisphosphonates can inhibit proliferation and cause apoptosis in human myeloma cells in vitro.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::da49663b1526ff225b6b570f5539ca59
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032404144&partnerID=MN8TOARS

Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma.

Autor: Croucher PI; Nuffield Department of Orthopaedic Surgery, University of Oxford, Nuffield Orthopaedic Centre, United Kingdom. peter.croucher@orthopaedic-surgery.oxford.ac.uk, Shipman CM, Lippitt J, Perry M, Asosingh K, Hijzen A, Brabbs AC, van Beek EJ, Holen I, Skerry TM, Dunstan CR, Russell GR, Van Camp B, Vanderkerken K

Publikováno v: Blood [Blood] 2001 Dec 15; Vol. 98 (13), pp. 3534-40.

Bisphosphonates--mechanisms of action in multiple myeloma.

Autor: Shipman CM; Division of Biochemical and Musculoskeletal Medicine, University of Sheffield, UK., Rogers MJ, Vanderkerken K, Van Camp B, Graham R, Russell G, Croucher PI

Publikováno v: Acta oncologica (Stockholm, Sweden) [Acta Oncol] 2000; Vol. 39 (7), pp. 829-35.

The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway.

Autor: Shipman CM; Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School, United Kingdom., Croucher PI, Russell RG, Helfrich MH, Rogers MJ

Publikováno v: Cancer research [Cancer Res] 1998 Dec 01; Vol. 58 (23), pp. 5294-7.