Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Shipeng, He"'
Drugtamer‐PROTAC Conjugation Strategy for Targeted PROTAC Delivery and Synergistic Antitumor Therapy
Publikováno v:
Advanced Science, Vol 11, Iss 25, Pp n/a-n/a (2024)
Abstract Proteolysis‐targeting chimeras (PROTACs) have emerged as a promising strategy for targeted protein degradation and drug discovery. To overcome the inherent limitations of conventional PROTACs, an innovative drugtamer‐PROTAC conjugation a
Externí odkaz:
https://doaj.org/article/5e51af81a35342deaca83ed1f163fd7e
Publikováno v:
Results in Chemistry, Vol 8, Iss , Pp 101608- (2024)
Novel hydrogen sulfide donor-based fibrate derivatives were synthesized and assessed for hypolipidemic and hepatoprotective effects in Triton WR-1339-induced hyperlipidemic mice. After preliminary screening of the target compounds, T5 exhibited signi
Externí odkaz:
https://doaj.org/article/e9f349f3982045ddbd63ea4669fcd777
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101400- (2024)
Hypolipidemic and hepatoprotective effectives of the newly synthesized guaiacol-based fibrate derivatives were evaluated in Triton WR-1339-induced hyperlipidemic mice. All the target compounds were preliminary screened, in which compound T5 showed si
Externí odkaz:
https://doaj.org/article/3024691bf09b4b59b7566b79750f3b73
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/e5a08bdaf73346e7b43ee43dddce81c3
Autor:
Depei Kong, Chen Ye, Chenxi Zhang, Xiaochen Sun, Fubo Wang, Rui Chen, Guangan Xiao, Shipeng He, Jianrong Xu, Xiwu Rao, Jianzhong Ai, Xu Gao, Hong Li, Li Su
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-21 (2023)
Abstract Background Bone is the most common site of metastasis of prostate cancer (PCa). PCa invasion leads to a disruption of osteogenic-osteolytic balance and causes abnormal bone formation. The interaction between PCa and bone stromal cells, espec
Externí odkaz:
https://doaj.org/article/40cffb13009346fea7f3939667e3d18d
Autor:
Shipeng He, Junhui Ma, Yuxin Fang, Ying Liu, Shanchao Wu, Guoqiang Dong, Wei Wang, Chunquan Sheng
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1617-1628 (2021)
The dose-related adverse effects of MDM2‒P53 inhibitors have caused significant concern in the development of clinical safe anticancer agents. Herein we report an unprecedented homo-PROTAC strategy for more effective disruption of MDM2‒P53 intera
Externí odkaz:
https://doaj.org/article/8d5578435fec442c91e420b01787c6aa
Autor:
Ying Liu, Wenjie Liu, Ziqiang Yu, Yan Zhang, Yinghua Li, Dantao Xie, Gang Xie, Li Fan, Shipeng He
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-11 (2021)
Abstract Bromodomain-containing protein 4 (BRD4) has emerged as a promising treatment target for bone-related disorders. (+)-JQ1, a thienotriazolodiazepine compound, has been shown to inhibit pro-osteoclastic activity in a BRD4-dependent approach and
Externí odkaz:
https://doaj.org/article/a11124e00feb407488c3fd6c0ac4f23b
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
B1-Leu peptide is a structural optimization compound derived from the lysine- and phenylalanine-rich antimicrobial peptide Cathelicidin-BF. It has shown promising antibacterial and antitumor biological activity. However, linear peptides are not the b
Externí odkaz:
https://doaj.org/article/e56fccc50141448c9edf990ea4b96940
Publikováno v:
Frontiers in Chemistry, Vol 9 (2022)
The emergence of multi-drug resistant bacteria and the lack of novel antibiotics to combat them have led to the revival of polymyxin B, a previously abandoned antibiotic due to its potential nephrotoxicity and neurotoxicity. To facilitate its widely
Externí odkaz:
https://doaj.org/article/3f3abd102eca48b188a705e55b8d1455
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
A4K14-citropin 1.1 is a structurally optimized derivative derived from amphibians' skin secreta peptide Citropin, which exhibits broad biological activities. However, the application of A4K14-citropin 1.1 as a cancer therapeutic is restricted by its
Externí odkaz:
https://doaj.org/article/66119847abdc46e3a8e3587ca7c95186