Zobrazeno 1 - 10
of 284
pro vyhledávání: '"Shiow-Lin Pan"'
Autor:
Chao-Di Chang, Min-Wu Chao, Hsueh-Yun Lee, Yi-Ting Liu, Huang-Ju Tu, Ssu-Ting Lien, Tony Eight Lin, Tzu-Ying Sung, Shih-Chung Yen, Sing-Han Huang, Kai-Cheng Hsu, Shiow-Lin Pan
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Inhibiting a specific target in cancer cells and reducing unwanted side effects has become a promising strategy in pancreatic cancer treatment. MAP4K4 is associated with pancreatic cancer development and correlates with poor clinical outcomes. By pho
Externí odkaz:
https://doaj.org/article/eeb87040e05f48b3ad27fb6a79897905
Publikováno v:
Heliyon, Vol 9, Iss 11, Pp e21774- (2023)
Erythropoietin-producing hepatocyte receptor type A2 (EphA2) is a tyrosine kinase that binds to ephrins (e.g., ephrin-A1) to initiate bidirectional signaling between cells. The binding of EphA2 and ephrin-A1 leads to the inhibition of Ras-MAPK activi
Externí odkaz:
https://doaj.org/article/e9b3cc0405cc490d91e2bed0ff2523a1
Autor:
Tai-Yuan Ho, Ting-Yi Sung, Shiow-Lin Pan, Wei-Jan Huang, Kai-Cheng Hsu, Jui-Yi Hsu, Tony Eight Lin, Chia-Ming Hsu, Chia-Ron Yang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 162, Iss , Pp 114667- (2023)
Prostate cancer is a prevalent malignancy among men globally, and androgen deprivation therapy is the conventional first-line treatment for metastatic prostate cancer. While androgen deprivation therapy is efficacious in castration-sensitive prostate
Externí odkaz:
https://doaj.org/article/5d7e46c37792443caf9c4aefa81a1f09
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12588 (2023)
Colorectal cancer (CRC) is one of the most commonly diagnosed malignancies and a leading cause of cancer worldwide. Histone deacetylases (HDACs), which regulate cell proliferation and survival, are associated with the development and progression of c
Externí odkaz:
https://doaj.org/article/77e539929ac24f22ac6017c58d3692be
Autor:
Yi-Wen Wu, Min-Wu Chao, Huang-Ju Tu, Liang-Chieh Chen, Kai-Cheng Hsu, Jing-Ping Liou, Chia-Ron Yang, Shih-Chung Yen, Wei-Chun HuangFu, Shiow-Lin Pan
Publikováno v:
Oncogenesis, Vol 10, Iss 5, Pp 1-14 (2021)
Abstract Acute leukemia is a highly heterogeneous disease; therefore, combination therapy is commonly used for patient treatment. Drug–drug interaction is a major concern of combined therapy; hence, dual/multi-target inhibitors have become a domina
Externí odkaz:
https://doaj.org/article/8dd26522ac6d4593b41471029e8816c9
Autor:
Ting-Yi Sung, Han-Li Huang, Chun-Chun Cheng, Fu-Ling Chang, Po-Li Wei, Ya-Wen Cheng, Cheng-Chiao Huang, Yu-Ching Lee, Wei-Chun HuangFu, Shiow-Lin Pan
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Background The availability of a reliable tumor target for advanced colorectal cancer (CRC) therapeutic approaches is critical since current treatments are limited. Epidermal growth factor-like domain 6 (EGFL6) has been reported to be associ
Externí odkaz:
https://doaj.org/article/9bbf162c729e43c9b4a3fe7a24f4256f
Autor:
Min-Wu Chao, Tony Eight Lin, Wei-Chun HuangFu, Chao-Di Chang, Huang-Ju Tu, Liang-Chieh Chen, Shih-Chung Yen, Tzu-Ying Sung, Wei-Jan Huang, Chia-Ron Yang, Shiow-Lin Pan, Kai-Cheng Hsu
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 98-108 (2021)
The STE20 kinase family is a complex signalling cascade that regulates cytoskeletal organisation and modulates the stress response. This signalling cascade includes various kinase mediators, such as TAOK1 and MAP4K5. The dysregulation of the STE20 ki
Externí odkaz:
https://doaj.org/article/a23f5c3bf07c4ef483bac5eb846abc10
Publikováno v:
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-8 (2020)
Abstract Background Despite the fact that histone deacetylase (HDAC) inhibitors have been tested to treat various cardiovascular diseases, the effects of selective HDAC6 inhibitor ACY1215 on infarct size during cardiac ischemia-reperfusion (IR) injur
Externí odkaz:
https://doaj.org/article/4f10a02731db406088ea9d201791927e
Autor:
Tony Eight Lin, Min-Wu Chao, Wei-Chun HuangFu, Huang-Ju Tu, Zhao-Xiang Peng, Chih-Jou Su, Tzu-Ying Sung, Jui-Hua Hsieh, Cheng-Chung Lee, Chia-Ron Yang, Shiow-Lin Pan, Kai-Cheng Hsu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 146, Iss , Pp 112580- (2022)
The dysregulation of DYRK1A is implicated in many diseases such as cancer, diabetes, and neurodegenerative diseases. Alzheimer’s disease is one of the most common neurodegenerative disease and has elevated interest in DYRK1A research. Overexpressio
Externí odkaz:
https://doaj.org/article/bde6aaca1032477f872fda9997782694
Autor:
Ting-Yu Chang, Kunal Nepali, Yi-Ying Chen, Yu-Chen S.H. Yang, Kai-Cheng Hsu, Yun Yen, Shiow-Lin Pan, Jing-Ping Liou, Sung-Bau Lee
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 138, Iss , Pp 111485- (2021)
Aberrant alteration of epigenetic information disturbs chromatin structure and gene function, thereby facilitating cancer development. Several drugs targeting histone deacetylases (HDACs), a group of epigenetic enzymes, have been approved for treatin
Externí odkaz:
https://doaj.org/article/d160c7e87c31481186b0ffae5b860668