Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Shiou-Chuan Tsai"'
Autor:
Lauren Ray, Timothy R. Valentic, Takeshi Miyazawa, David M. Withall, Lijiang Song, Jacob C. Milligan, Hiroyuki Osada, Shunji Takahashi, Shiou-Chuan Tsai, Gregory L. Challis
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Polyketides are typically assembled from a starter unit and malonyl- and/or methylmalonyl-CoA-derived extender units, but the macrolide antibiotics stambomycins incorporate non-standard alkylmalonyl-CoA extender units. Here, the authors describe the
Externí odkaz:
https://doaj.org/article/f13d3b5a30894fbfb9a232d6e4194380
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7562 (2020)
Polyketides are a large class of structurally and functionally diverse natural products with important bioactivities. Many polyketides are synthesized by reducing type II polyketide synthases (PKSs), containing transiently interacting standalone enzy
Externí odkaz:
https://doaj.org/article/d22810cd64d447c1ac0a974df077ec7a
Publikováno v:
Journal of chemical information and modeling, vol 61, iss 2
J Chem Inf Model
J Chem Inf Model
Pantetheine is ubiquitous in nature in various forms of pantetheine-containing ligands (PCLs), including coenzyme A and phosphopantetheine. Lack of scalable force field libraries for PCLs has hampered the computational studies of biological macromole
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 20
International Journal of Molecular Sciences, Vol 21, Iss 7562, p 7562 (2020)
Volume 21
Issue 20
International Journal of Molecular Sciences, Vol 21, Iss 7562, p 7562 (2020)
Polyketides are a large class of structurally and functionally diverse natural products with important bioactivities. Many polyketides are synthesized by reducing type II polyketide synthases (PKSs), containing transiently interacting standalone enzy
Autor:
Shiou-Chuan Tsai
Publikováno v:
Annual Review of Biochemistry. 87:503-531
Polyketides are a large family of structurally complex natural products including compounds with important bioactivities. Polyketides are biosynthesized by polyketide synthases (PKSs), multienzyme complexes derived evolutionarily from fatty acid synt
Autor:
Michael D. Burkart, Joseph J. Hale, Shiou-Chuan Tsai, D. John Lee, David R. Jackson, Ray Luo, Jesus F. Barajas, Joris Beld, Andrew J. Schaub, Jacob C. Milligan
Publikováno v:
Nature chemical biology, vol 15, iss 7
Nat Chem Biol
Nat Chem Biol
Fatty acid synthases are dynamic ensembles of enzymes that can biosynthesize long hydrocarbon chains efficiently. Here we visualize the interaction between the Escherichia coli acyl carrier protein (AcpP) and β-ketoacyl-ACP-synthase I (FabB) using X
Publikováno v:
ACS Chemical Biology. 11:3421-3430
Arixanthomycins are pentangular polyphenols (PP) with potent antiproliferative activities that were discovered through the heterologous expression of environmental DNA-derived gene clusters. The biosynthesis of arixanthomycin and other PPs is unusual
Autor:
Paulina K. Sydor, Joleen Masschelein, Timothy R. Valentic, Daniel Griffiths, Vilmos Fülöp, Neil J. Oldham, Józef R. Lewandowski, Angelo Gallo, Emmanuel L. C. de los Santos, Shiou-Chuan Tsai, Gregory L. Challis, Matthew Jenner, Shanshan Zhou, Lucio Manzi, Simone Kosol, Dean Rea
Publikováno v:
Nature Chemistry, vol 11, iss 10
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Nature chemistry
Nature chemistry, vol 11, iss 10
Nature Chemistry
UnpayWall
ORCID
Microsoft Academic Graph
Datacite
CORE (RIOXX-UK Aggregator)
Lirias
Sygma
PubMed Central
CORE
Nature chemistry
Nature chemistry, vol 11, iss 10
Nature Chemistry
Modular polyketide synthases and non-ribosomal peptide synthetases are molecular assembly lines that consist of several multienzyme subunits that undergo dynamic self-assembly to form a functional megacomplex. N- and C-terminal docking domains are us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99745ffd52627eeaf7f2fc926a62df29
https://escholarship.org/uc/item/75m6f7xm
https://escholarship.org/uc/item/75m6f7xm
Publikováno v:
Methods Enzymol
Various computational methodologies can be applied to enzymological studies on enzymes in the fatty acid, polyketide, and non-ribosomal peptide biosynthetic pathways. These multi-domain complexes are called fatty acid synthases, polyketide synthases,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::451c64b5669bdba01a7aa46a6361654e
https://escholarship.org/uc/item/6qs7v0qs
https://escholarship.org/uc/item/6qs7v0qs
Autor:
Gaurav Shakya, Jordan L. Meier, Craig A. Townsend, Timothy R. Valentic, Jesus F. Barajas, Nathan Gamarra, Kara Finzel, Delsy Martinez, Anna L. Vagstad, Adam G. Newman, Shiou-Chuan Tsai, Michael D. Burkart
Publikováno v:
Angewandte Chemie (International ed. in English), vol 55, iss 42
In fungal non-reducing polyketide synthases (NR-PKS), the acyl-carrier protein (ACP) carries the growing polyketide intermediate through iterative rounds of elongation, cyclization and product release. This process occurs through a controlled, yet en