Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Shion A. Lim"'
Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers
Autor:
Shion A. Lim, Jie Zhou, Alexander J. Martinko, Yung-Hua Wang, Ekaterina V. Filippova, Veronica Steri, Donghui Wang, Soumya G. Remesh, Jia Liu, Byron Hann, Anthony A. Kossiakoff, Michael J. Evans, Kevin K. Leung, James A. Wells
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 4 (2022)
Extracellular proteolysis is frequently dysregulated in disease and can generate proteoforms with unique neoepitopes not found in healthy tissue. Here, we demonstrate that Abs that selectively recognize a proteolytic neoepitope on CUB domain containi
Externí odkaz:
https://doaj.org/article/185e24f5d7a047799beb370607485344
Autor:
Shion A. Lim, Josef A. Gramespacher, Katarina Pance, Nicholas J. Rettko, Paige Solomon, Jing Jin, Irene Lui, Susanna K. Elledge, Jia Liu, Colton J. Bracken, Graham Simmons, Xin X. Zhou, Kevin K. Leung, James A. Wells
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Numerous neutralizing antibodies that target SARS-CoV-2 have been reported, and most directly block binding of the viral Spike receptor-binding domain (RBD) to angiotensin-converting enzyme II (ACE2). Here, we deliberately exploit non-neutralizing RB
Externí odkaz:
https://doaj.org/article/58387a18a15c49f9b2ec691ffba6d02b
Autor:
James R. Byrnes, Xin X. Zhou, Irene Lui, Susanna K. Elledge, Jeff E. Glasgow, Shion A. Lim, Rita P. Loudermilk, Charles Y. Chiu, Taia T. Wang, Michael R. Wilson, Kevin K. Leung, James A. Wells
Publikováno v:
mSphere, Vol 5, Iss 5 (2020)
ABSTRACT As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread around the world, there is an urgent need for new assay formats to characterize the humoral response to infection. Here, we present an efficient, competitive
Externí odkaz:
https://doaj.org/article/37d9f89d63ed4f75ab01f6157803f4a4
Autor:
Michael J. Evans, Rahul Aggarwal, James A. Wells, Jonathan Chou, Eric J. Small, Felix Y. Feng, Youngho Seo, Emily Chan, Renuka Sriram, Adam Foye, Li Zhang, Jun Zhu, Emily A. Egusa, Kevin K. Leung, Shion A. Lim, Jie Zhou, Hyunjung Kim, Nima Hooshdaran, Sasank Sakhamuri, Yung-Hua Wang, Kai Trepka, Shalini Chopra, Ning Zhao
Supplementary Table from CUB Domain-Containing Protein 1 (CDCP1) Is a Target for Radioligand Therapy in Castration-Resistant Prostate Cancer, including PSMA Null Disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7202861d7ba2f0a879bfc4b29eba348
https://doi.org/10.1158/1078-0432.22486157.v1
https://doi.org/10.1158/1078-0432.22486157.v1
Autor:
Michael J. Evans, James A. Wells, Kimberly S. Kirkwood, Eric A. Collisson, Kevin K. Leung, Sean Carlin, Youngho Seo, Lydia H. Zhang, Shion A. Lim, Jie Zhuo, Alexander J. Martinko, Zhuo Chen, Yangjie Huang, Ning Zhao, Junnian Wei, Jeremy M. Sharib, Yung-Hua Wang, Anna Moroz
Purpose:The recent emergence of radioligand therapies for cancer treatment has increased enthusiasm for developing new theranostic strategies coupling both imaging and cytotoxicity in the same entity. In this study, we evaluated whether CUB domain co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a058b3064dd4e9ecfa3f980c0898668c
https://doi.org/10.1158/1078-0432.c.6528857
https://doi.org/10.1158/1078-0432.c.6528857
Autor:
Michael J. Evans, Rahul Aggarwal, James A. Wells, Jonathan Chou, Eric J. Small, Felix Y. Feng, Youngho Seo, Emily Chan, Renuka Sriram, Adam Foye, Li Zhang, Jun Zhu, Emily A. Egusa, Kevin K. Leung, Shion A. Lim, Jie Zhou, Hyunjung Kim, Nima Hooshdaran, Sasank Sakhamuri, Yung-Hua Wang, Kai Trepka, Shalini Chopra, Ning Zhao
Supplementary Figure from CUB Domain-Containing Protein 1 (CDCP1) Is a Target for Radioligand Therapy in Castration-Resistant Prostate Cancer, including PSMA Null Disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c57f6fa7feebd91bb46f1e618ae91cc
https://doi.org/10.1158/1078-0432.22486163.v1
https://doi.org/10.1158/1078-0432.22486163.v1
Autor:
Michael J. Evans, Rahul Aggarwal, James A. Wells, Jonathan Chou, Eric J. Small, Felix Y. Feng, Youngho Seo, Emily Chan, Renuka Sriram, Adam Foye, Li Zhang, Jun Zhu, Emily A. Egusa, Kevin K. Leung, Shion A. Lim, Jie Zhou, Hyunjung Kim, Nima Hooshdaran, Sasank Sakhamuri, Yung-Hua Wang, Kai Trepka, Shalini Chopra, Ning Zhao
Purpose:With the improvement in overall survival with 177Lu-PSMA 617, radioligand therapy (RLT) is now a viable option for patients with metastatic castration-resistant prostate cancer (mCRPC). However, responses are variable, in part due to low PSMA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b082113f876c3ce1134300d647cec0f
https://doi.org/10.1158/1078-0432.c.6532265.v1
https://doi.org/10.1158/1078-0432.c.6532265.v1
Autor:
Michael J. Evans, James A. Wells, Kimberly S. Kirkwood, Eric A. Collisson, Kevin K. Leung, Sean Carlin, Youngho Seo, Lydia H. Zhang, Shion A. Lim, Jie Zhuo, Alexander J. Martinko, Zhuo Chen, Yangjie Huang, Ning Zhao, Junnian Wei, Jeremy M. Sharib, Yung-Hua Wang, Anna Moroz
Supplemental methods, figures, and tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd76320a99a43971b362aaab78f2138e
https://doi.org/10.1158/1078-0432.22474655
https://doi.org/10.1158/1078-0432.22474655
BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2
Autor:
Quang Dinh Tran, Xiaoyan Guo, Jonathan S. Weissman, Jared Carlson-Stevermer, Marco Vignuzzi, Jennifer Oki, Shion A. Lim, Merissa Chen, Sarah J. Rockwood, Kevin Holden, James K. Nuñez, Avi J. Samelson, Travis J. Maures, Veronica V. Rezelj, James A. Wells, Gokul N. Ramadoss, Bruce R. Conklin, Martin Kampmann, Na Liu, Irene Lui, Alice Mac Kain, Ruilin Tian
Publikováno v:
Nature Cell Biology
Nature Cell Biology, 2022, 24 (1), pp.24-34. ⟨10.1038/s41556-021-00821-8⟩
Nature cell biology, vol 24, iss 1
bioRxiv
article-version (status) pre
article-version (number) 1
Nature Cell Biology, 2022, 24 (1), pp.24-34. ⟨10.1038/s41556-021-00821-8⟩
Nature cell biology, vol 24, iss 1
bioRxiv
article-version (status) pre
article-version (number) 1
SARS-CoV-2 infection of human cells is initiated by the binding of the viral Spike protein to its cell-surface receptor ACE2. We conducted a targeted CRISPRi screen to uncover druggable pathways controlling Spike protein binding to human cells. We fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9836aaa4388fd836bf4f32463f43d9e4
https://hal-pasteur.archives-ouvertes.fr/pasteur-04133563/file/samelson_kampmann_nihms-1759623.pdf
https://hal-pasteur.archives-ouvertes.fr/pasteur-04133563/file/samelson_kampmann_nihms-1759623.pdf
Autor:
Nicholas J. Agard, Peter S. Dragovich, Ryan L. Kelly, Shion A. Lim, Allison M. Beal, Ian Moench, Anna M. Gram, Pei-Pei Kung, Daša Lipovšek
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35ae0feec8bc4e0efe319f5c4f279989
https://doi.org/10.29200/acsmedchemrev-v56.ch22
https://doi.org/10.29200/acsmedchemrev-v56.ch22