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Autor:
Hiroyuki Nakahira, Yukihiro Nishio, Mutsuko Sakai, Michiko Ono, Shinya Tosaki, Eiji Sugaru, Masakuni Horiguchi, Hidenori Kimura, Tsutomu Nakagawa, Yumi Masui
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7246-7249
Structures containing the (R)-3-amino-3-methyl piperidine unit as a new pharmacophore moiety have been shown to possess moderate inhibitory activity for DPP-4 with good pharmacokinetics profile. One of these compounds was found to have good oral bioa