Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Shinya Tasaki"'
Autor:
Randy L. Parrish, Aron S. Buchman, Shinya Tasaki, Yanling Wang, Denis Avey, Jishu Xu, Philip L. De Jager, David A. Bennett, Michael P. Epstein, Jingjing Yang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Multiple reference panels of a given tissue or multiple tissues often exist, and multiple regression methods could be used for training gene expression imputation models for transcriptome-wide association studies (TWAS). To leverage expressi
Externí odkaz:
https://doaj.org/article/e1438fafdf334bde867c5aecd9114757
Autor:
Shahram Oveisgharan, Lei Yu, Katia de Paiva Lopes, Vladislav A. Petyuk, Shinya Tasaki, Ricardo Vialle, Vilas Menon, Yanling Wang, Philip L. De Jager, Julie A. Schneider, David A. Bennett
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Accumulation of amyloid-β (Aβ) and tau tangles are hallmarks of Alzheimer’s disease. Aβ is extracellular while tau tangles are typically intracellular, and it is unknown how these two proteinopathies are connected. Here, we use data of
Externí odkaz:
https://doaj.org/article/db373cb64bd548c290a7761d99ec2353
Autor:
Namhee Kim, Timothy Truty, S. Duke Han, Moonseong Heo, Aron S. Buchman, David A. Bennett, Shinya Tasaki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The Mini-Mental State Examination (MMSE) is a widely employed screening tool for the severity of cognitive impairment. Among the MMSE items, the pentagon copying test (PCT) requires participants to accurately replicate a sample of two interl
Externí odkaz:
https://doaj.org/article/9648b841486f43168813086fa2c70205
Publikováno v:
Frontiers in Dementia, Vol 3 (2024)
Externí odkaz:
https://doaj.org/article/e241be0bd2d145c48142d688fc6c38a9
Autor:
Dallin Dressman, Shinya Tasaki, Lei Yu, Julie Schneider, David A. Bennett, Wassim Elyaman, Badri Vardarajan
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionT cells, known for their ability to respond to an enormous variety of pathogens and other insults, are increasingly recognized as important mediators of pathology in neurodegeneration and other diseases. T cell gene expression phenotypes
Externí odkaz:
https://doaj.org/article/646c5968fcb94a70ae74307220e0da11
Autor:
Chris Gaiteri, David R. Connell, Faraz A. Sultan, Artemis Iatrou, Bernard Ng, Boleslaw K. Szymanski, Ada Zhang, Shinya Tasaki
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-27 (2023)
Abstract Clustering molecular data into informative groups is a primary step in extracting robust conclusions from big data. However, due to foundational issues in how they are defined and detected, such clusters are not always reliable, leading to u
Externí odkaz:
https://doaj.org/article/3f74f51a008c47ccbc239894876d10e3
Autor:
Shizhen Tang, Aron S. Buchman, Yanling Wang, Denis Avey, Jishu Xu, Shinya Tasaki, David A. Bennett, Qi Zheng, Jingjing Yang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Differential gene expression (DGE) analysis has been widely employed to identify genes expressed differentially with respect to a trait of interest using RNA sequencing (RNA-Seq) data. Recent RNA-Seq data with large samples pose challenges t
Externí odkaz:
https://doaj.org/article/21db5ad10c5c4445ab22518c39ef6d6c
Autor:
Shinya Tasaki, Namhee Kim, Tim Truty, Ada Zhang, Aron S. Buchman, Melissa Lamar, David A. Bennett
Publikováno v:
npj Digital Medicine, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Hand drawing, which requires multiple neural systems for planning and controlling sequential movements, is a useful cognitive test for older adults. However, the conventional visual assessment of these drawings only captures limited attribut
Externí odkaz:
https://doaj.org/article/4aa9b9a442444109806fa26146b536d5
Autor:
Jakob Seidlitz, Travis T. Mallard, Jacob W. Vogel, Younga H. Lee, Varun Warrier, Gareth Ball, Oskar Hansson, Leanna M. Hernandez, Ayan S. Mandal, Konrad Wagstyl, Michael V. Lombardo, Eric Courchesne, Joseph T. Glessner, Theodore D. Satterthwaite, Richard A.I. Bethlehem, Joshua D. Bernstock, Shinya Tasaki, Bernard Ng, Chris Gaiteri, Jordan W. Smoller, Tian Ge, Raquel E. Gur, Michael J. Gandal, Aaron F. Alexander-Bloch
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113439- (2023)
Summary: Human brain size changes dynamically through early development, peaks in adolescence, and varies up to 2-fold among adults. However, the molecular genetic underpinnings of interindividual variation in brain size remain unknown. Here, we leve
Externí odkaz:
https://doaj.org/article/64ee1401f7fc44968f6a52b884af8318
Autor:
Shinya Tasaki, Jishu Xu, Denis R. Avey, Lynnaun Johnson, Vladislav A. Petyuk, Robert J. Dawe, David A. Bennett, Yanling Wang, Chris Gaiteri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Protein changes in a brain with Alzheimer’s are not often accompanied by transcriptional differences. Here, using a deep neural network that predicts protein abundance from mRNA expression, the authors track the early protein changes in Alzheimer
Externí odkaz:
https://doaj.org/article/b2326e42adbe43e48a6a4b74d7fb329d