Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Shinya Taniguchi"'
Autor:
Seiji Hayashi, Yoshihide Kii, Mitsuyasu Tabo, Hitoshi Fukuda, Tetsuji Itoh, Takashi Shimosato, Hideto Amano, Mamoru Saito, Hajime Morimoto, Kiyoshi Yamada, Atsuhiro Kanda, Toshimasa Ishitsuka, Takanobu Yamazaki, Yoichi Kiuchi, Shinya Taniguchi, Tatsuya Mori, Shigekazu Shimizu, Yuji Tsurubuchi, Shun-ichi Yasuda, Shin-ichi Kitani, Chiaki Shimada, Kazuo Kobayashi, Masaharu Komeno, Chieko Kasai, Toshiyasu Hombo, Keiji Yamamoto
Publikováno v:
Journal of Pharmacological Sciences, Vol 99, Iss 5, Pp 423-437 (2005)
To construct a non-clinical database for drug-induced QT interval prolongation, the electrophysiological effects of 11 positive and 10 negative compounds on action potentials (AP) in guinea-pig papillary muscles were investigated in a multi-site stud
Externí odkaz:
https://doaj.org/article/a0418258c79346d3ac043532653edbdc
Autor:
Yoshihide Kii, Seiji Hayashi, Mitsuyasu Tabo, Takashi Shimosato, Hitoshi Fukuda, Tetsuji Itoh, Hideto Amano, Mamoru Saito, Hajime Morimoto, Kiyoshi Yamada, Atsuhiro Kanda, Toshimasa Ishitsuka, Takanobu Yamazaki, Yoichi Kiuchi, Shinya Taniguchi, Tatsuya Mori, Shigekazu Shimizu, Yuji Tsurubuchi, Shun-ichi Yasuda, Shin-ichi Kitani, Chiaki Shimada, Kazuo Kobayashi, Masaharu Komeno, Chieko Kasai, Toshiyasu Hombo, Keiji Yamamoto
Publikováno v:
Journal of Pharmacological Sciences, Vol 99, Iss 5, Pp 449-457 (2005)
Certain compounds that prolong QT interval in humans have little or no effect on action-potential (AP) duration used traditionally, but they inhibit rapidly-activated-delayed-rectifier potassium currents (IKr) and/or human ether-a-go-go-related gene
Externí odkaz:
https://doaj.org/article/607f605ce3e84d8090d1635dfe43b73c
Autor:
Atsushi Nakajima, Sonoko Ishizaki, Kazuki Matsuda, Shinsuke Kurosu, Shinya Taniguchi, Per‐Göran Gillberg, Jan P Mattsson, Tomoko Hasunuma, Michael Camilleri
Publikováno v:
Journal of gastroenterology and hepatology. 37(5)
Elobixibat is a locally acting inhibitor of the ileal bile acid transporter. We compared bile acid metabolism between healthy subjects and patients with chronic constipation and assessed changes in the bile acid profile after elobixibat administratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116ce6cbd7b84303c1e24a21405de009
https://pubmed.ncbi.nlm.nih.gov/35168298
https://pubmed.ncbi.nlm.nih.gov/35168298
Publikováno v:
Folia Pharmacologica Japonica. 153:129-138
Elobixibat is a novel small-molecule that acts as an inhibitor of the ileal bile acid transporter (IBAT), and used for chronic constipation in Japan. Elobixibat selectively inhibited IBAT in vitro, and dose-dependently inhibited the absorption of bil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bb3bba84370be0fdbc191399067d10d
https://doi.org/10.1254/fpj.153.129
https://doi.org/10.1254/fpj.153.129
Autor:
Shinya Taniguchi, Daisuke Miyoshi, Natsuki Kinoshita, Shin Kuwamoto, Mitsuki Tsuruta, Ryoto Urano, Takeru Torii, Yoshiki Hashimoto, Keiko Kawauchi
Publikováno v:
Genes, Vol 11, Iss 1340, p 1340 (2020)
Genes
Genes
G-quadruplex (G4) is the non-canonical secondary structure of DNA and RNA formed by guanine-rich sequences. G4-forming sequences are abundantly located in telomeric regions and in the promoter and untranslated regions (UTR) of cancer-related genes, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61a02b7b5279110342081346e5b5e3a
https://www.mdpi.com/2073-4425/11/11/1340
https://www.mdpi.com/2073-4425/11/11/1340
Autor:
Mitsunori Seki, Junzo Hagimoto, Kazuo Hamai, Shinya Taniguchi, Kenji Hiranabe, Hironori Washizaki, Hiroshi Kobayashi, Eiichi Hanyuda, Takeshi Inoue
Publikováno v:
COMPSAC
Successful digital transformation (DX) requires not only technology, but also an understanding of the importance of business agility. In addition, without careful traceability, software engineering projects can be not based on business and social val
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::285136eab0bf603ee9d27a81ec50337d
https://doi.org/10.1109/compsac48688.2020.0-111
https://doi.org/10.1109/compsac48688.2020.0-111
Autor:
Mitsunori Seki, Akira Ohta, Atsushi Nakajima, Per Göran Gillberg, Jan P. Mattsson, Michael Camilleri, Shinya Taniguchi
Publikováno v:
The Lancet Gastroenterology & Hepatology. 3:537-547
A subset of patients with constipation has reduced colonic bile acid concentrations, which are associated with slow colonic transit. In a previous study, elobixibat, a locally acting ileal bile acid transporter inhibitor, accelerated colonic transit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6999ab24a2ac35dd9c3d478693fac032
https://doi.org/10.1016/s2468-1253(18)30123-7
https://doi.org/10.1016/s2468-1253(18)30123-7
Autor:
Shinya Taniguchi, Michael Camilleri, Shinsuke Kurosu, Tomoko Hasunuma, Sonoko Ishizaki, Per-Göran Gillberg, Atsushi Nakajima, Jan P. Mattsson
Publikováno v:
Gastroenterology. 158:S-394
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48a52f1d36b24ef3a377806b6684bf6f
https://doi.org/10.1016/s0016-5085(20)31677-2
https://doi.org/10.1016/s0016-5085(20)31677-2
Autor:
Shinya Taniguchi, Per Göran Gillberg, Michael Camilleri, Jan P. Mattsson, Shinsuke Kurosu, Atsushi Nakajima
Publikováno v:
Neurogastroenterology and Motility
Background In two phase 3 trials, elobixibat, a locally acting ileal bile acid transporter inhibitor, resolved constipation and was well tolerated in Japanese patients with chronic constipation. We analyzed the efficacy, safety, and impact on quality
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8b613c18e9522074b2fe013238240c4
https://pubmed.ncbi.nlm.nih.gov/30793431
https://pubmed.ncbi.nlm.nih.gov/30793431
Publikováno v:
Journal of Gastroenterology
Background Elobixibat is an oral treatment candidate for chronic constipation with a novel mechanism of action via inhibition of the ileal bile acid transporter. We performed this randomized, double-blind, placebo-controlled, dose-finding phase IIb s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f04e9aebfbc4e6088a57a9eaab3584
https://pubmed.ncbi.nlm.nih.gov/28840422
https://pubmed.ncbi.nlm.nih.gov/28840422