Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Shinya Ohashi"'
Autor:
Chikatoshi Katada, Tetsuji Yokoyama, Tomonori Yano, Haruhisa Suzuki, Yasuaki Furue, Keiko Yamamoto, Hisashi Doyama, Tomoyuki Koike, Masashi Tamaoki, Noboru Kawata, Motohiro Hirao, Yoshiro Kawahara, Takashi Ogata, Atsushi Katagiri, Takenori Yamanouchi, Hirofumi Kiyokawa, Hirofumi Kawakubo, Maki Konno, Akira Yokoyama, Shinya Ohashi, Yuki Kondo, Yo Kishimoto, Koichi Kano, Kanae Mure, Ryuichi Hayashi, Hideki Ishikawa, Manabu Muto
Publikováno v:
DEN Open, Vol 4, Iss 1, Pp n/a-n/a (2024)
Abstract The development of multiple squamous cell carcinomas (SCC) in the upper aerodigestive tract, which includes the oral cavity, pharynx, larynx, and esophagus, is explained by field cancerization and is associated with alcohol consumption and c
Externí odkaz:
https://doaj.org/article/544b82b2425b43b09792e6b64868b783
Autor:
Yosuke Mitani, Shinya Ohashi, Osamu Kikuchi, Yukie Nakai, Tomomi Ida, Ayaka Mizumoto, Yoshihiro Yamamoto, Tomoki Saito, Shigeki Kataoka, Junichi Matsubara, Atsushi Yamada, Masashi Kanai, Shigemi Matsumoto, Hiroaki Sakai, Kiyotsugu Yoshikawa, Eijiro Nakamura, Manabu Muto
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Clinical cancer genome sequencing detects oncogenic variants that are potential targets for cancer treatment, but it also detects variants of unknown significance. These variants may interact with each other to influence tumor pathophysiolog
Externí odkaz:
https://doaj.org/article/a5a28560b24a488aa789094fa8f44f21
Autor:
Manabu Muto, Chikatoshi Katada, Tetsuji Yokoyama, Tomonori Yano, Ichiro Oda, Yasumasa Ezoe, Satoshi Tanabe, Yuichi Shimizu, Hisashi Doyama, Tomoyuki Koike, Kohei Takizawa, Motohiro Hirao, Hiroyuki Okada, Takashi Ogata, Atsushi Katagiri, Takenori Yamanouchi, Yasumasa Matsuo, Hirofumi Kawakubo, Tai Omori, Nozomu Kobayashi, Tadakazu Shimoda, Atsushi Ochiai, Hideki Ishikawa, Kiichiro Baba, Yusuke Amanuna, Akira Yokoyama, Shinya Ohashi, Kazuhiro Kaneko, Shuko Morita, Makiko Funakoshi, Takahiro Horimatsu, Mari Takahashi, Haruhisa Suzuki, Satoshi Abiko, Kenichi Takemura, Hiroyoshi Nakanishi, Masahiro Saito, Nobuyuki Ara, Naomi Kakushima, Masaki Tanaka, Keisuke Hori, Takashi Tsuda
Publikováno v:
Gastro Hep Advances, Vol 1, Iss 2, Pp 265-276 (2022)
Background and Aims: Multiple developments of squamous dysplasia and squamous cell carcinoma (SCC) in the upper aerodigestive tract have been explained by field cancerization phenomenon and were associated with alcohol and cigarette use. Second prima
Externí odkaz:
https://doaj.org/article/7c4721312f034de1bf71339554d298d2
Autor:
Yosuke Mitani, Masashi Kanai, Tadayuki Kou, Shigeki Kataoka, Keitaro Doi, Junichi Matsubara, Shinya Ohashi, Shigemi Matsumoto, Manabu Muto
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-5 (2020)
Abstract Background Cancer of unknown primary (CUP) is usually treated with nonselective and empirical chemotherapy; however, its prognosis is generally poor, with a median survival of less than a year. Thus, clinicians eagerly await the development
Externí odkaz:
https://doaj.org/article/3bc43c03efe142a7a21826fd5b7c99a4
Autor:
Takashi Kijima, Hiroshi Nakagawa, Masataka Shimonosono, Prasanna M. Chandramouleeswaran, Takeo Hara, Varun Sahu, Yuta Kasagi, Osamu Kikuchi, Koji Tanaka, Veronique Giroux, Amanda B. Muir, Kelly A. Whelan, Shinya Ohashi, Seiji Naganuma, Andres J. Klein-Szanto, Yoshiaki Shinden, Ken Sasaki, Itaru Omoto, Yoshiaki Kita, Manabu Muto, Adam J. Bass, J. Alan Diehl, Gregory G. Ginsberg, Yuichiro Doki, Masaki Mori, Yasuto Uchikado, Takaaki Arigami, Narayan G. Avadhani, Devraj Basu, Anil K. Rustgi, Shoji Natsugoe
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 73-91 (2019)
Background & Aims: Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, thr
Externí odkaz:
https://doaj.org/article/7488edc6ab024bcda04958703e1f2938
Autor:
Prasanna M Chandramouleeswaran, Manti Guha, Masataka Shimonosono, Kelly A Whelan, Hisatsugu Maekawa, Uma M Sachdeva, Gordon Ruthel, Sarmistha Mukherjee, Noah Engel, Michael V Gonzalez, James Garifallou, Shinya Ohashi, Andres J Klein-Szanto, Clementina A Mesaros, Ian A Blair, Renata Pellegrino da Silva, Hakon Hakonarson, Eishi Noguchi, Joseph A Baur, Hiroshi Nakagawa
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239625 (2020)
During alcohol consumption, the esophageal mucosa is directly exposed to high concentrations of ethanol (EtOH). We therefore investigated the response of normal human esophageal epithelial cell lines EPC1, EPC2 and EPC3 to acute EtOH exposure. While
Externí odkaz:
https://doaj.org/article/5a4df4b8798b4fd795ef2f8d80b295c8
Autor:
Aoi Komatsu, Kotaro Matsumoto, Yuki Yoshimatsu, Yooksil Sin, Arisa Kubota, Tomoki Saito, Ayaka Mizumoto, Shinya Ohashi, Manabu Muto, Rei Noguchi, Tadashi Kondo, Fuyuhiko Tamanoi
Publikováno v:
Cells, Vol 10, Iss 10, p 2613 (2021)
(1) Background: CIC-DUX4 sarcoma is a rare mesenchymal small round cell tumor which belongs to rare cancers that occupy a significant percentage of cancer cases as a whole, despite each being rare. Importantly, each rare cancer type has different fea
Externí odkaz:
https://doaj.org/article/02378917d035406b8b6ad8d4317c7bd6
Autor:
Ayaka Mizumoto, Shinya Ohashi, Kenshiro Hirohashi, Yusuke Amanuma, Tomonari Matsuda, Manabu Muto
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 9, p 1943 (2017)
Acetaldehyde is a highly reactive compound that causes various forms of damage to DNA, including DNA adducts, single- and/or double-strand breaks (DSBs), point mutations, sister chromatid exchanges (SCEs), and DNA–DNA cross-links. Among these, DNA
Externí odkaz:
https://doaj.org/article/9b1fa0deeeb0429696cf73e238761d7a
Autor:
Shinya Ohashi, Osamu Kikuchi, Mihoko Tsurumaki, Yukie Nakai, Hiroi Kasai, Takahiro Horimatsu, Shin'ichi Miyamoto, Akira Shimizu, Tsutomu Chiba, Manabu Muto
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103126 (2014)
Photodynamic therapy (PDT) kills cancer cells via a photochemical reaction mediated by an oncotropic photosensitizer. Herein, we performed an experimental preclinical study to validate the anti-tumour effect of talaporfin sodium-mediated PDT (t-PDT)
Externí odkaz:
https://doaj.org/article/c3cb8617c2904b1a94e13f8281c8783e
Autor:
Samuel Flashner, Masataka Shimonosono, Norihiro Matsuura, Shinya Ohashi, Andres J. Klein-Szanto, J. Alan Diehl, Che-Hong Chen, Daria Mochly-Rosen, Hiroshi Nakagawa
The alcohol metabolite acetaldehyde is a potent human carcinogen. Aldehyde dehydrogenase 2 (ALDH2) is the primary enzyme that detoxifies acetaldehyde in the mitochondria. Acetaldehyde accumulates and causes genotoxic stress in cells expressing the dy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84ad695e0f6cee8a6a618115f7082b25
https://doi.org/10.1101/2023.04.03.534985
https://doi.org/10.1101/2023.04.03.534985