Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Shinya Neri"'
Autor:
Nan Li, Yifan Wang, Shinya Neri, Yuanli Zhen, Lon Wolf R. Fong, Yawei Qiao, Xu Li, Zhen Chen, Clifford Stephan, Weiye Deng, Rui Ye, Wen Jiang, Shuxing Zhang, Yonghao Yu, Mien-Chie Hung, Junjie Chen, Steven H. Lin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The LKB1/AMPK is crucial for maintaining cellular homeostasis and is often deregulated in tumours. Here, the authors show that the ribosylation of LKB1 by tankyrase-RNF146 axis results in attenuation of LKB1 pathway activation.
Externí odkaz:
https://doaj.org/article/9b4222506e07478e9b0dbb2ab2af74f5
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Since the approval of anti-CTLA4 therapy (ipilimumab) for late-stage melanoma in 2011, the development of anticancer immunotherapy agents has thrived. The success of many immune-checkpoint inhibitors has drastically changed the landscape of cancer tr
Externí odkaz:
https://doaj.org/article/1e42ce3feda542559055e6e093d8e5c5
Autor:
Jack A. Roth, Jeffrey Morris, Elizabeth J. Shpall, Peggy T. Tinkey, Steven H. Lin, Bingliang Fang, Shinya Neri, Min Jin Ha, RuPing Shao, Feng Meng, Mourad Majidi, Ismail M. Meraz
Human tumor xenograft models do not replicate the human immune system and tumor microenvironment. We developed an improved humanized mouse model, derived from fresh cord blood CD34+ stem cells (CD34+ HSC), and combined it with lung cancer cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3713fa87cc4612f94e7d2f910bdaf859
https://doi.org/10.1158/2326-6066.c.6550158
https://doi.org/10.1158/2326-6066.c.6550158
Autor:
Jack A. Roth, Jeffrey Morris, Elizabeth J. Shpall, Peggy T. Tinkey, Steven H. Lin, Bingliang Fang, Shinya Neri, Min Jin Ha, RuPing Shao, Feng Meng, Mourad Majidi, Ismail M. Meraz
Legends to Figures S1-S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3897c795c0fd8abb06ec670ba85b898d
https://doi.org/10.1158/2326-6066.22543152
https://doi.org/10.1158/2326-6066.22543152
Autor:
Jack A. Roth, Jeffrey Morris, Elizabeth J. Shpall, Peggy T. Tinkey, Steven H. Lin, Bingliang Fang, Shinya Neri, Min Jin Ha, RuPing Shao, Feng Meng, Mourad Majidi, Ismail M. Meraz
Figure S1-S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c170cf599f64a3bc617e2830a742073
https://doi.org/10.1158/2326-6066.22543149.v1
https://doi.org/10.1158/2326-6066.22543149.v1
Autor:
Atsushi Ochiai, Yuichiro Ohe, Kanji Nagai, Akio Niimi, Shinsuke Iida, Hironobu Ohmatsu, Shingo Matsumoto, Shigeki Umemura, Seiji Niho, Kiyotaka Yoh, Hiroko Hashimoto, Shinya Neri, Koichi Goto, Genichiro Ishii, Tatsuya Yoshida
Supplemental Tables 1-4. Supplemental Table 1: Characteristics of primary adenocarcinoma from which CAFs were obtained. Supplemental Table 2: Primary tumor characteristics(N=106). Supplemental Table 3: Impact of predictive factors on progression free
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142bdbd49a479a9542f316d308df142a
https://doi.org/10.1158/1078-0432.22455114
https://doi.org/10.1158/1078-0432.22455114
Autor:
Atsushi Ochiai, Yuichiro Ohe, Kanji Nagai, Akio Niimi, Shinsuke Iida, Hironobu Ohmatsu, Shingo Matsumoto, Shigeki Umemura, Seiji Niho, Kiyotaka Yoh, Hiroko Hashimoto, Shinya Neri, Koichi Goto, Genichiro Ishii, Tatsuya Yoshida
Supplemental Figures 1-6. Supplemental Figure 1: Fluorescence microscopy showing mRFP-labeled PC-9 (red) and Venus-labeled CAFs (green) with or without gefitinib treatment. Supplemental Figure 2: mRNA levels of podoplanin (PDPN) in CAF-Ctrl and CAF P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b540945ae8047e1f0255bbae5b80cb
https://doi.org/10.1158/1078-0432.22455117.v1
https://doi.org/10.1158/1078-0432.22455117.v1
Autor:
Atsushi Ochiai, Yuichiro Ohe, Kanji Nagai, Akio Niimi, Shinsuke Iida, Hironobu Ohmatsu, Shingo Matsumoto, Shigeki Umemura, Seiji Niho, Kiyotaka Yoh, Hiroko Hashimoto, Shinya Neri, Koichi Goto, Genichiro Ishii, Tatsuya Yoshida
Supplemental Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10562166edd31a9569b48bae8e8d14b7
https://doi.org/10.1158/1078-0432.22455120
https://doi.org/10.1158/1078-0432.22455120
Autor:
Atsushi Ochiai, Yuichiro Ohe, Kanji Nagai, Akio Niimi, Shinsuke Iida, Hironobu Ohmatsu, Shingo Matsumoto, Shigeki Umemura, Seiji Niho, Kiyotaka Yoh, Hiroko Hashimoto, Shinya Neri, Koichi Goto, Genichiro Ishii, Tatsuya Yoshida
Purpose: The biologic characteristics of microenvironmental constituents, especially cancer-associated fibroblasts (CAF), can be key regulators of the cellular sensitivity to molecular-targeted therapy. Epidermal growth factor receptor tyrosine kinas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ae07b9035dd680721021bb5edcb050
https://doi.org/10.1158/1078-0432.c.6522924
https://doi.org/10.1158/1078-0432.c.6522924
Autor:
Steven H. Lin, R Sadagopan, Pankaj Singh, Julianne M. Pollard-Larkin, Sunil Krishnan, Amrish Sharma, Jessica Symons, Ramesh C. Tailor, Shinya Neri, Bhanu Prasad Venkatesulu
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Recent reports have shown that very high dose rate radiation (35–100 Gy/second) referred to as FLASH tends to spare the normal tissues while retaining the therapeutic effect on tumor. We undertook a series of experiments to assess if ultra-high dos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31815eca7399ae6f32a00eda2ab67b32
http://link.springer.com/article/10.1038/s41598-019-53562-y
http://link.springer.com/article/10.1038/s41598-019-53562-y