Výsledky vyhledávání - "Shinya Hosaka"

In vivoindividual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9

Autor: Shinya Hosaka, Yusuke Kitsugi, Shotaro Uehara, Yasuhiro Uno, Kazuhide Iwasaki, Takahiro Yoshikawa, Masahiro Utoh, Hiroshi Yamazaki, Kanami Ikeda

Publikováno v: Biopharmaceutics & Drug Disposition. 37:379-383

Cynomolgus monkeys are frequently used in preclinical studies for new drug development due to their evolutionary closeness to humans. An antiretroviral drug efavirenz is a typical probe substrate for human cytochrome P450 (P450) 2B6, but is mainly me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b979e0b55cc3eb64a0532fc7545f4b9d
https://doi.org/10.1002/bdd.2021

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Identification of putative substrates for cynomolgus monkey cytochrome P450 2C8 by substrate depletion assays with 22 human P450 substrates and inhibitors

Autor: Makiko Shimizu, Norie Murayama, Shotaro Uehara, Yasuhiro Uno, Shinya Hosaka, Shunsuke Iwano, Hiroshi Yamazaki, Kazuhide Iwasaki, Masahiro Satsukawa

Publikováno v: Biopharmaceutics & Drug Disposition. 37:310-313

Cynomolgus monkeys are widely used in drug developmental stages as non-human primate models. Previous studies used 89 compounds to investigate species differences associated with cytochrome P450 (P450 or CYP) function that reported monkey specific CY

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3777174a59f5934209f73ac4eea32f2e
https://doi.org/10.1002/bdd.1998

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Autor: Hiroshi Yamazaki, Kazuhide Iwasaki, Norie Murayama, Shunsuke Iwano, Makiko Shimizu, Masahiro Satsukawa, Shotaro Uehara, Yasuhiro Uno, Shinya Hosaka

Publikováno v: Biopharmaceutics & Drug Disposition. 36:636-643

Cynomolgus monkeys are used widely in preclinical studies as non-human primate species. The amino acid sequence of cynomolgus monkey cytochrome P450 (P450 or CYP) 2C19 is reportedly highly correlated to that of human CYP2C19 (92%) and CYP2C9 (93%). I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6578973be16c33657ce54b03138ecd49
https://doi.org/10.1002/bdd.1991

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Comprehensive Evaluation for Substrate Selectivity of Cynomolgus Monkey Cytochrome P450 2C9, a New Efavirenz Oxidase

Autor: Shotaro Uehara, Masahiro Satsukawa, Yasuhiro Uno, Shinya Hosaka, Shunsuke Iwano, Kazuhide Iwasaki, Norie Murayama, Makiko Shimizu, Hiroshi Yamazaki

Publikováno v: Drug Metabolism and Disposition. 43:1119-1122

Cynomolgus monkeys are widely used as primate models in preclinical studies, because of their evolutionary closeness to humans. In humans, the cytochrome P450 (P450) 2C enzymes are important drug-metabolizing enzymes and highly expressed in livers. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550172ac4d591dfe69bf2b4c7729e85e
https://doi.org/10.1124/dmd.115.063925

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Evaluation of 89 Compounds for Identification of Substrates for Cynomolgus Monkey CYP2C76, a New Bupropion/Nifedipine Oxidase

Autor: Yasuhiro Uno, Masahiro Satsukawa, Shinya Hosaka, Makiko Shimizu, Shotaro Uehara, Hideki Fujino, Hiroshi Yamazaki, Norie Murayama, Kazuhide Iwasaki, Shunsuke Iwano

Publikováno v: Drug Metabolism and Disposition. 43:27-33

Cynomolgus monkeys are widely used in preclinical studies during drug development because of their evolutionary closeness to humans, including their cytochrome P450s (P450s). Most cynomolgus monkey P450s are almost identical (≥90%) to human P450s;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3fcd3547b1f3b8b37ba9d6ef209a2f
https://doi.org/10.1124/dmd.114.061275

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The Low Keratin Affinity of Efinaconazole Contributes to Its Nail Penetration and Fungicidal Activity in Topical Onychomycosis Treatment

Autor: William J. Jo Siu, Yoshio Arakawa, Maria Katafuchi-Nagashima, Noriaki Sugimoto, Radhakrishnan Pillai, Shinya Hosaka, Yoshiyuki Tatsumi, Keita Sugiura

Publikováno v: Antimicrobial Agents and Chemotherapy. 58:3837-3842

Onychomycosis is a common fungal nail disease that is difficult to treat topically due to the deep location of the infection under the densely keratinized nail plate. Keratin affinity of topical drugs is an important physicochemical property impactin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d32253448bfb07ca0b33650c24c6a63
https://doi.org/10.1128/aac.00111-14

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Identification and Analysis of CYP7A1, CYP17A1, CYP20A1, CYP27A1 and CYP51A1 in Cynomolgus Macaques

Autor: Yasuhiro Uno, Hiroshi Yamazaki, Shinya Hosaka

Publikováno v: The Journal of Veterinary Medical Science

Cytochromes P450 (P450) are important for not only drug metabolism and toxicity, but also biosynthesis and metabolism of cholesterol and bile acids, and steroid synthesis. In cynomolgus macaques, widely used in biomedical research, we have characteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b3e4730074129810e2ea4eda48aa27
https://doi.org/10.1292/jvms.14-0313

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In vivo individual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9

Autor: Kazuhide, Iwasaki, Yusuke, Kitsugi, Kanami, Ikeda, Takahiro, Yoshikawa, Shinya, Hosaka, Shotaro, Uehara, Yasuhiro, Uno, Masahiro, Utoh, Hiroshi, Yamazaki

Publikováno v: Biopharmaceuticsdrug disposition. 37(6)

Cynomolgus monkeys are used frequently in preclinical studies for new drug development due to their evolutionary closeness to humans. An antiretroviral drug, efavirenz, is a typical probe substrate for human cytochrome P450 (P450) 2B6, but is mainly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ea7c42a50cc76901eb347fc580775327
https://pubmed.ncbi.nlm.nih.gov/27417918

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