Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Shinya Hosaka"'
Autor:
Tsuyoshi Mayumi, Shinya Hosaka, Yutaka Yasuda, Takuho Ishii, Makoto Niwa, Tatsuya Yamakawa, Ayumi Ueda, Naoko Nakai
Publikováno v:
Bioanalysis. 12:7-10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d9e1236ea363a3b783ce370e0a4dac
https://doi.org/10.4155/bio-2019-0217
https://doi.org/10.4155/bio-2019-0217
Autor:
Tsuyoshi Mayumi, Takuho Ishii, Shinya Hosaka, Keita Ono, Yutaka Yasuda, Makoto Niwa, Naoko Nakai, Saori Kuriyama, Tatsuya Yamakawa
Publikováno v:
Bioanalysis. 10:1553-1556
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85d52df13f9df18078824c40c0e296a
https://doi.org/10.4155/bio-2018-0217
https://doi.org/10.4155/bio-2018-0217
Autor:
Shinya Hosaka, Yusuke Kitsugi, Shotaro Uehara, Yasuhiro Uno, Kazuhide Iwasaki, Takahiro Yoshikawa, Masahiro Utoh, Hiroshi Yamazaki, Kanami Ikeda
Publikováno v:
Biopharmaceutics & Drug Disposition. 37:379-383
Cynomolgus monkeys are frequently used in preclinical studies for new drug development due to their evolutionary closeness to humans. An antiretroviral drug efavirenz is a typical probe substrate for human cytochrome P450 (P450) 2B6, but is mainly me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b979e0b55cc3eb64a0532fc7545f4b9d
https://doi.org/10.1002/bdd.2021
https://doi.org/10.1002/bdd.2021
Autor:
Makiko Shimizu, Norie Murayama, Shotaro Uehara, Yasuhiro Uno, Shinya Hosaka, Shunsuke Iwano, Hiroshi Yamazaki, Kazuhide Iwasaki, Masahiro Satsukawa
Publikováno v:
Biopharmaceutics & Drug Disposition. 37:310-313
Cynomolgus monkeys are widely used in drug developmental stages as non-human primate models. Previous studies used 89 compounds to investigate species differences associated with cytochrome P450 (P450 or CYP) function that reported monkey specific CY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3777174a59f5934209f73ac4eea32f2e
https://doi.org/10.1002/bdd.1998
https://doi.org/10.1002/bdd.1998
Autor:
Shotaro Uehara, Masahiro Satsukawa, Yasuhiro Uno, Shinya Hosaka, Shunsuke Iwano, Kazuhide Iwasaki, Norie Murayama, Makiko Shimizu, Hiroshi Yamazaki
Publikováno v:
Drug Metabolism and Disposition. 43:1119-1122
Cynomolgus monkeys are widely used as primate models in preclinical studies, because of their evolutionary closeness to humans. In humans, the cytochrome P450 (P450) 2C enzymes are important drug-metabolizing enzymes and highly expressed in livers. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550172ac4d591dfe69bf2b4c7729e85e
https://doi.org/10.1124/dmd.115.063925
https://doi.org/10.1124/dmd.115.063925
Autor:
Yasuhiro Uno, Masahiro Satsukawa, Shinya Hosaka, Makiko Shimizu, Shotaro Uehara, Hideki Fujino, Hiroshi Yamazaki, Norie Murayama, Kazuhide Iwasaki, Shunsuke Iwano
Publikováno v:
Drug Metabolism and Disposition. 43:27-33
Cynomolgus monkeys are widely used in preclinical studies during drug development because of their evolutionary closeness to humans, including their cytochrome P450s (P450s). Most cynomolgus monkey P450s are almost identical (≥90%) to human P450s;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3fcd3547b1f3b8b37ba9d6ef209a2f
https://doi.org/10.1124/dmd.114.061275
https://doi.org/10.1124/dmd.114.061275
Autor:
William J. Jo Siu, Yoshio Arakawa, Maria Katafuchi-Nagashima, Noriaki Sugimoto, Radhakrishnan Pillai, Shinya Hosaka, Yoshiyuki Tatsumi, Keita Sugiura
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:3837-3842
Onychomycosis is a common fungal nail disease that is difficult to treat topically due to the deep location of the infection under the densely keratinized nail plate. Keratin affinity of topical drugs is an important physicochemical property impactin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d32253448bfb07ca0b33650c24c6a63
https://doi.org/10.1128/aac.00111-14
https://doi.org/10.1128/aac.00111-14
Publikováno v:
The Journal of Veterinary Medical Science
Cytochromes P450 (P450) are important for not only drug metabolism and toxicity, but also biosynthesis and metabolism of cholesterol and bile acids, and steroid synthesis. In cynomolgus macaques, widely used in biomedical research, we have characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b3e4730074129810e2ea4eda48aa27
https://doi.org/10.1292/jvms.14-0313
https://doi.org/10.1292/jvms.14-0313
Autor:
Kazuhide, Iwasaki, Yusuke, Kitsugi, Kanami, Ikeda, Takahiro, Yoshikawa, Shinya, Hosaka, Shotaro, Uehara, Yasuhiro, Uno, Masahiro, Utoh, Hiroshi, Yamazaki
Publikováno v:
Biopharmaceuticsdrug disposition. 37(6)
Cynomolgus monkeys are used frequently in preclinical studies for new drug development due to their evolutionary closeness to humans. An antiretroviral drug, efavirenz, is a typical probe substrate for human cytochrome P450 (P450) 2B6, but is mainly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ea7c42a50cc76901eb347fc580775327
https://pubmed.ncbi.nlm.nih.gov/27417918
https://pubmed.ncbi.nlm.nih.gov/27417918
Autor:
Shinya, Hosaka, Norie, Murayama, Masahiro, Satsukawa, Shotaro, Uehara, Makiko, Shimizu, Kazuhide, Iwasaki, Shunsuke, Iwano, Yasuhiro, Uno, Hiroshi, Yamazaki
Publikováno v:
Biopharmaceuticsdrug disposition. 37(5)
Cynomolgus monkeys are widely used in drug developmental stages as non-human primate models. Previous studies used 89 compounds to investigate species differences associated with cytochrome P450 (P450 or CYP) function that reported monkey specific CY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0be1fcbaab0806c9a2c0f676fbe4d0ee
https://pubmed.ncbi.nlm.nih.gov/26581561
https://pubmed.ncbi.nlm.nih.gov/26581561