Zobrazeno 1 - 10
of 405
pro vyhledávání: '"Shinya Honda"'
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
Excessive exposure to sunlight, especially to ultraviolet B (UVB), results in DNA damage and a cutaneous inflammatory reaction commonly known as sunburn, which increases skin cancer risks. UVB-induced inflammasome activation in epidermal keratinocyte
Externí odkaz:
https://doaj.org/article/24abf1609935479db1b75b4a8f530fb9
Publikováno v:
FEBS Open Bio, Vol 13, Iss 10, Pp 1910-1921 (2023)
Improving protein stability is important for industrial applications, and one promising method for achieving this is backbone circularization. As connector length affects stability, predicting and elucidating a more stable connector length is necessa
Externí odkaz:
https://doaj.org/article/acced1f7a7ae41c2a86cb1277273666e
Autor:
Satoru Torii, Satoko Arakawa, Shigeto Sato, Kei‐ichi Ishikawa, Daisuke Taniguchi, Hajime Tajima Sakurai, Shinya Honda, Yuuichi Hiraoka, Masaya Ono, Wado Akamatsu, Nobutaka Hattori, Shigeomi Shimizu
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 9, Pp n/a-n/a (2023)
Abstract Parkinson's disease (PD) is a common neurodegenerative disorder that results from the loss of dopaminergic neurons. Mutations in coiled‐coil‐helix‐coiled‐coil‐helix domain containing 2 (CHCHD2) gene cause a familial form of PD with
Externí odkaz:
https://doaj.org/article/171e40dcebbe419cb1dfbf178948b2a9
Autor:
Hajime Tajima Sakurai, Satoko Arakawa, Hirofumi Yamaguchi, Satoru Torii, Shinya Honda, Shigeomi Shimizu
Publikováno v:
Cells, Vol 12, Iss 24, p 2817 (2023)
Autophagy is a cellular mechanism that utilizes lysosomes to degrade its own components and is performed using Atg5 and other molecules originating from the endoplasmic reticulum membrane. On the other hand, we identified an alternative type of autop
Externí odkaz:
https://doaj.org/article/b6be29614b6245cb953e21820430d583
Autor:
Hiroshi Imamura, Shinya Honda
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12042 (2023)
Antibody aggregation, followed by acid denaturation and neutralization of pH, is one of the reasons why the production of therapeutic monoclonal antibodies (mAbs) is expensive. Determining the structural details of acid-denatured antibodies is import
Externí odkaz:
https://doaj.org/article/6499adb9050c4859bcf550d6cea62bb0
Publikováno v:
Microbial Biotechnology, Vol 14, Iss 3, Pp 979-992 (2021)
Summary The yeast Saccharomyces cerevisiae, widely used for ethanol production, is one of the best‐understood biological systems. Diploid strains of S. cerevisiae are preferred for industrial use due to the better fermentation efficiency, in terms
Externí odkaz:
https://doaj.org/article/52575174fb6b4fafafb9ef6bbf05418c
Autor:
Tomoya Kinumi, Kazumi Saikusa, Megumi Kato, Reiko Kojima, Chieko Igarashi, Naohiro Noda, Shinya Honda
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Monoclonal antibodies have been established as the largest product class of biopharmaceuticals. Since extensive characterization is required for development and quality control of monoclonal antibody, a widely available reference material (RM) is nee
Externí odkaz:
https://doaj.org/article/5524705afbf44de499162c3e8a9593d2
Autor:
Hirofumi Yamaguchi, Shinya Honda, Satoru Torii, Kimiko Shimizu, Kaoru Katoh, Koichi Miyake, Noriko Miyake, Nobuhiro Fujikake, Hajime Tajima Sakurai, Satoko Arakawa, Shigeomi Shimizu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Unlike canonical macroautophagy, alternative autophagy does not require the factors Atg5 and Atg7. Here, the authors show that Wipi3 is essential for alternative autophagy, but not for canonical autophagy, and that Wipi3 functions to maintain neurona
Externí odkaz:
https://doaj.org/article/e374571e97c940f285c7df2fe5d6193d
Autor:
Satoru Torii, Hirofumi Yamaguchi, Akira Nakanishi, Satoko Arakawa, Shinya Honda, Kenta Moriwaki, Hiroyasu Nakano, Shigeomi Shimizu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Unlike canonical macroautophagy, alternative autophagy does not require the factors Atg5 and Atg7, but does require Ulk1. Here the authors show that phosphorylation of Ulk1 at Ser746 by RIPK3 is required for alternative autophagy initiation at the Go
Externí odkaz:
https://doaj.org/article/3f3a5cabe5ec4005addc0c3f0c1db251
Autor:
Meruna Nagata, Satoko Arakawa, Hirofumi Yamaguchi, Satoru Torii, Hazuki Endo, Masatsune Tsujioka, Shinya Honda, Yuya Nishida, Akimitsu Konishi, Shigeomi Shimizu
Publikováno v:
Cell Stress, Vol 2, Iss 3, Pp 55-65 (2018)
Autophagy is an evolutionarily conserved process that degrades subcellular constituents. Mammalian cells undergo two types of autophagy; Atg5-dependent conventional autophagy and Atg5-independent alternative autophagy, and the molecules required for
Externí odkaz:
https://doaj.org/article/21378226cf8547ceb93fb120b6711255