Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Shinya Mitsuhashi"'
Autor:
Albertus Eka Yudistira Sarwono, Shinya Mitsuhashi, Mohammad Hazzaz Bin Kabir, Kengo Shigetomi, Tadashi Okada, Fumina Ohsaka, Satoko Otsuguro, Katsumi Maenaka, Makoto Igarashi, Kentaro Kato, Makoto Ubukata
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 171-178 (2019)
Inosine 5′-monophosphate dehydrogenase (IMPDH) is an essential enzyme for the production of guanine nucleotides. Disruption of IMPDH activity has been explored as a therapeutic strategy for numerous purposes, such as for anticancer, immunosuppressi
Externí odkaz:
https://doaj.org/article/5853f45477c74c8dbfdc2be048baba82
Publikováno v:
Molecules, Vol 13, Iss 12, Pp 2998-3006 (2008)
As multiple mechanisms account for polyphenol-induced cytotoxicity, the development of structure-activity relationships (SARs) may facilitate research on cancer therapy. We studied SARs of representatives of 10 polyphenol structural types: (+)-catech
Externí odkaz:
https://doaj.org/article/728d63e4ad4b4b268689bfcea67c24f1
Autor:
Jun'ichi Kobayashi, Kunimi Kikuchi, Naohito Aoki, Shinya Mitsuhashi, Tadashi Okada, Hiroshi Shima, Takaaki Kubota, Yusuke Wakuda
Publikováno v:
Marine Drugs, Vol 4, Iss 1, Pp 9-14 (2006)
Abstract: Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 a
Externí odkaz:
https://doaj.org/article/69313788837644529adee0b4295bac9a
Autor:
Torry A. Tucker, Yoshikazu Tsukasaki, Shinya Mitsuhashi, Tsuyoshi Sakai, Ann Jeffers, Mitsuo Ikebe, Steven Idell, Satoshi Komatsu
Publikováno v:
Am J Respir Cell Mol Biol
Pleural fibrosis is characterized by severe inflammation of the pleural space and pleural reorganization. Subsequent thickening of the visceral pleura contributes to lung stiffness and impaired lung function. Pleural mesothelial cells (PMCs) can beco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ac601bfbe513d653b7fb9339818943
https://doi.org/10.1165/rcmb.2018-0121oc
https://doi.org/10.1165/rcmb.2018-0121oc
Publikováno v:
Wood Science and Technology. 52:873-886
Advanced glycation end-products (AGEs) are one of the pivotal factors that cause a variety of diabetes complications. To explore a new class of natural resources that can prevent AGEs formation, the inhibitory activities of tree bark extracts against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f03a886c348668140364f9a76c43e67c
https://doi.org/10.1007/s00226-018-1002-5
https://doi.org/10.1007/s00226-018-1002-5
Publikováno v:
Journal of Wood Science. 65
Toxoplasma gondii is an intracellular protozoan parasite of which infection can result in serious symptoms for fetuses or people who have weakened immune system. In our effort to discover novel anti-toxoplasma substances from tree barks, only outer b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::404cc8c647a06a559e817a0d7a4579f6
https://doi.org/10.1186/s10086-019-1782-8
https://doi.org/10.1186/s10086-019-1782-8
Publikováno v:
The Journal of antibiotics. 71(10)
A novel bacteriocin-like protein and its structural gene (rap) were identified from Rhodococcus erythropolis JCM 2895. The rapA and B genes are located on a 5.4-kb circular plasmid, and were obtained using a modified suppression-subtractive hybridiza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f66d74f9aefc599903635b07f80fcd
https://pubmed.ncbi.nlm.nih.gov/29980745
https://pubmed.ncbi.nlm.nih.gov/29980745
Autor:
Yasuhiro Tanaka, Ryogo Takai, Yoichi Kamagata, Makoto Ubukata, Kengo Shigetomi, Mohammad Nazrul Islam Bhuiyan, Shinya Mitsuhashi
Publikováno v:
The Journal of Antibiotics. 69:97-103
We have identified coproporphyrins including structurally new zincmethylphyrins I and III as growth factors A-F for the previously uncultured bacterial strain, Leucobacter sp. ASN212, from a supernatant of 210 l of Sphingopyxis sp. GF9 culture. Growt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c2e4ba22395a52df2bfda57ca76dd0c
https://doi.org/10.1038/ja.2015.87
https://doi.org/10.1038/ja.2015.87
Publikováno v:
The Journal of Antibiotics. 68:721-724
A novel autophagy inducer, (+)-epogymnolactam (1), was first synthesized from cis-4-benzyloxy-2-butene-1-ol (2) in eight steps. A reliable preparation of optically pure epoxy alcohol (+)-3 from monobenzyl derivative (2) was established by a tandem st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f69bd71e515fd37de9ee82327d5f29
https://doi.org/10.1038/ja.2015.63
https://doi.org/10.1038/ja.2015.63
Autor:
Makoto Ubukata, Shinya Mitsuhashi, Albertus Eka Yudistira Sarwono, Molefe Nthatisi, Tadashi Okada, Marcin Jąkalski, Keisuke Suganuma, Junya Yamagishi, Noboru Inoue
Publikováno v:
Antimicrobial agents and chemotherapy. 60(7):4391-4393
application/pdf
This study aimed to evaluate the trypanocidal activity of mycophenolic acid (MPA) and its derivatives for Trypanosoma congolense. The proliferation of T. congolense was completely inhibited by adding
This study aimed to evaluate the trypanocidal activity of mycophenolic acid (MPA) and its derivatives for Trypanosoma congolense. The proliferation of T. congolense was completely inhibited by adding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fddb3e304c3fc5bc84dd11621f8f03a2
http://hdl.handle.net/2115/76882
http://hdl.handle.net/2115/76882