Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Shinya, Hisakawa"'
Autor:
Masayoshi Ogawa, Shinji Suzuki, Kosuke Anan, Ken-ichi Kusakabe, Akihiro Takada, Shinya Hisakawa, Takuya Oguma
Publikováno v:
The Journal of Organic Chemistry. 84:4893-4897
The synthesis of a 6-CF3-substituted 2-amino-dihydro-1,3-thiazine via N,N-diethylaminosulfur trifluoride (DAST)-mediated cyclization of N-hydroxypropyl thiourea 6 is described. This reaction gave 6-CF3-1,3-thiazine 7 with high chemical yield and chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fb6e826b2dfc114707893cecd3d163b
https://doi.org/10.1021/acs.joc.8b02179
https://doi.org/10.1021/acs.joc.8b02179
Autor:
Takuya, Oguma, Kosuke, Anan, Shinji, Suzuki, Shinya, Hisakawa, Akihiro, Takada, Masayoshi, Ogawa, Ken-Ichi, Kusakabe
Publikováno v:
The Journal of organic chemistry. 84(8)
The synthesis of a 6-CF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ed200cd2f28d8e53b12e45de2e12f69
https://pubmed.ncbi.nlm.nih.gov/30371078
https://pubmed.ncbi.nlm.nih.gov/30371078
Autor:
Jun Sato, Yasushi Hasegawa, Kenji Yamawaki, Takafumi Sato, Masayuki Sano, Shinya Hisakawa, Masakatsu Tsuji, Yasuhiro Nishitani, Toshiaki Aoki, Toru Nishikawa, Hiroki Kusano, Rio Nakamura, Hidenori Yoshizawa, Katsuki Yokoo, Yoshinori Yamano, Hideki Sugimoto
Publikováno v:
European journal of medicinal chemistry. 155
The structure-activity relationship (SAR) for a novel series of catechol conjugated siderophore cephalosporins is described with their in vitro activities against multi-drug resistant Gram-negative pathogens including Pseudomonas aeruginosa, Acinetob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1fb65f3d6afacc1db14fba6f5f13f1
https://pubmed.ncbi.nlm.nih.gov/29960205
https://pubmed.ncbi.nlm.nih.gov/29960205
Autor:
Hidehiko Nakagawa, Shinya Hisakawa, Takayoshi Suzuki, Mineko Kurotaki, Yukihiro Itoh, Sakiko Maruyama, Naoki Miyata
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1558-1561
To identify prodrugs of a thiolate histone deacetylase inhibitor NCH-31 that show potent antiproliferative activity and are stable in human plasma, we synthesized several candidate prodrugs of NCH-31. Among these compounds, S-2-methyl-3-phenylpropano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf2fef596cbb401315b079cba73b616
https://doi.org/10.1016/j.bmcl.2006.12.117
https://doi.org/10.1016/j.bmcl.2006.12.117
Autor:
Takayoshi Suzuki, Minoru Yoshida, Shinya Hisakawa, Naoki Miyata, Hidehiko Nakagawa, Yukihiro Itoh, Akiyasu Kouketsu, Satoko Maeda
Publikováno v:
Journal of Medicinal Chemistry. 49:4809-4812
To find novel histone deacetylase 6 (HDAC6)-selective inhibitors and clarify the structural requirements for HDAC6-selective inhibition, we prepared thiolate analogues designed based on the structure of an HDAC6-selective substrate and evaluated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6871783de4b3821130f85e14abdd2d
https://doi.org/10.1021/jm060554y
https://doi.org/10.1021/jm060554y
Autor:
Shinya Hisakawa, Naoki Miyata, Azusa Matsuura, Hidehiko Nakagawa, Takayoshi Suzuki, Akiyasu Kouketsu
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:4332-4342
A series of suberoylanilide hydroxamic acid (SAHA)-based non-hydroxamates was designed, synthesized, and evaluated for their histone deacetylase (HDAC) inhibitory activity. Among these, methyl sulfoxide 15 inhibited HDACs in enzyme assays and caused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502cc2343111b05f4466109495a5613a
https://doi.org/10.1016/j.bmc.2005.04.002
https://doi.org/10.1016/j.bmc.2005.04.002
Autor:
Shinya Hisakawa, Hidehiko Nakagawa, Takayoshi Suzuki, Katsumasa Takahashi, Kentaro Yamaguchi, Yukihiro Itoh, Masatoshi Kawahata, Naoki Miyata, Nobuaki Suzuki
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(15)
Aiming to develop selective anticancer drugs, we designed and synthesized three disulfides bearing a folic acid moiety as candidate folate receptor (FR)-targeted prodrugs of thiolate histone deacetylase inhibitors. Among them, compound 1 displayed gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded1087cdc337196755b2dde299a3b7c
https://pubmed.ncbi.nlm.nih.gov/17532630
https://pubmed.ncbi.nlm.nih.gov/17532630