Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Shintaro Noguchi"'
Antibody drugs are usually formulated as highly-concentrated solutions, which would easily generate oligomer and aggregation, resulting in loss of efficacy. Although low pH increases the colloidal dispersion of antibodies, acid denaturation can be an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf618247e146e6b584db614d439d5557
http://arxiv.org/abs/2207.06556
http://arxiv.org/abs/2207.06556
Autor:
Takahiro Furukawa, Satoshi Sano, Kanako Shima, Shintaro Noguchi, Kazufumi Takano, Kouji Kuramochi, Chikashi Ota, Kazunori Tsubaki
Publikováno v:
ChemistrySelect. 2:1267-1270
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45f3a042cfd263a4d40a7e6b086eb41e
https://doi.org/10.1002/slct.201601949
https://doi.org/10.1002/slct.201601949
Publikováno v:
Pharmaceutical Research. 33:956-969
To investigate the protein–protein interactions of a highly concentrated antibody solution that could cause oligomerization or aggregation and to develop a better understanding of the optimization of drug formulations. In this study, we used Raman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7729d3f6a013b0c56c83e08431c56e
https://doi.org/10.1007/s11095-015-1842-8
https://doi.org/10.1007/s11095-015-1842-8
Publikováno v:
Biopolymers. 103:237-246
We used Raman spectroscopy to investigate the structure and interactions of lysozyme molecules in solution over a wide range of concentrations (2.5-300 mg ml(-1)). No changes in the amide-I band were observed as the concentration was increased, but t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dd701b0a41a060585588f081070c5c0
https://doi.org/10.1002/bip.22593
https://doi.org/10.1002/bip.22593
Publikováno v:
Biopolymers. 103(4)
We used Raman spectroscopy to investigate the structure and interactions of lysozyme molecules in solution over a wide range of concentrations (2.5-300 mg ml(-1)). No changes in the amide-I band were observed as the concentration was increased, but t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d595caf972edbe581fabf7b6eff53434
https://pubmed.ncbi.nlm.nih.gov/25418947
https://pubmed.ncbi.nlm.nih.gov/25418947
Publikováno v:
Seibutsu Butsuri. 54:S154
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83c1891d22580acab2247caa58fc4b5f
https://doi.org/10.2142/biophys.54.s154_5
https://doi.org/10.2142/biophys.54.s154_5