Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Shintaro Kusaka"'
Autor:
Kazuki Yamamoto, Toyotaka Sato, Aili Hao, Kenta Asao, Rintaro Kaguchi, Shintaro Kusaka, Radhakrishnam Raju Ruddarraju, Daichi Kazamori, Kiki Seo, Satoshi Takahashi, Motohiro Horiuchi, Shin-ichi Yokota, Seok-Yong Lee, Satoshi Ichikawa
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract MraY (phospho-N-acetylmuramoyl-pentapeptide-transferase) inhibitory natural products are attractive molecules as candidates for a new class of antibacterial agents to combat antimicrobial-resistant bacteria. Structural optimization of these
Externí odkaz:
https://doaj.org/article/8640ff4ee8c741c084f0f712332ebe3b
Autor:
Kazuki Yamamoto, Toyotaka Sato, Aili Hao, Kenta Asao, Rintaro Kaguchi, Shintaro Kusaka, Ruddarraju Raju, Daichi Kazamori, Kiki Seo, Satoshi Takahashi, Motohiro Horiuchi, Shin-ichi Yokota, Seok-Yong Lee, Satoshi ichikawa
Optimization of natural products is often required to improve their drug-like properties for therapeutic use. However, chemical modifications of natural products are painstaking tasks due to complex synthetic processes, which is a bottleneck in advan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b900b4587d4f40e93eec4f968f1bdbf
https://doi.org/10.26434/chemrxiv-2023-2w41l
https://doi.org/10.26434/chemrxiv-2023-2w41l
Publikováno v:
Bioorganicmedicinal chemistry. 73
The total synthesis of capuramycin (1), which is a promising anti-tubercular antibiotics, has been accomplished using Ferrier-type I reaction as a key step. This total synthesis is an alternative approach to the synthesis of capuramycin and its analo
Publikováno v:
Bioorganicmedicinal chemistry. 65
It is important to understand and control the biologically active conformation in medicinal chemistry. Muraymycins and caprazamycins, which are strong inhibitors of MraY, are promising antibacterial agents with a novel mode of action. Focusing on a s
Autor:
Shintaro Kusaka, Shinji Tanimori, Mari Mukumoto, Miki Ishimura, Yoshihide Hattori, Tomoyuki Asano, Mitsunori Kirihata, Koji Ono, Shin-ichiro Masunaga, Hiroshi Takenaka, Minoru Suzuki, Kouki Uehara, Yoichiro Ohta
Publikováno v:
Amino Acids. 46:2715-2720
Boron-neutron capture therapy (BNCT) is an attractive technique for cancer treatment. As such, α, α-cycloalkyl amino acids containing thiododecaborate ([B12H11](2-)-S-) units were designed and synthesized as novel boron delivery agents for BNCT. In
Autor:
Shintaro Kusaka, Mitsunori Kirihata, Tomoyuki Asano, Kouki Uehara, Shinji Tanimori, Yoshihide Hattori
Publikováno v:
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 69(12)
A convenient and simple synthetic method of dodecaboratethio-L-amino acid, a new class of tumor-seeking boron carrier for BNCT, was accomplished from S-cyanoethylthioundecahydro-closo-dodecaborate (S-cyanoethyl-(10)BSH, [(10)B(12)H(11)](2-)SCH(2)CH(2