Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Shinsuke Tokumoto"'
Autor:
Tomonobu Hatoko, Norio Harada, Shinsuke Tokumoto, Shunsuke Yamane, Eri Ikeguchi-Ogura, Tomoko Kato, Takuma Yasuda, Hisato Tatsuoka, Satoko Shimazu-Kuwahara, Daisuke Yabe, Yoshitaka Hayashi, Nobuya Inagaki
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Tissue optical clearing permits detailed evaluation of organ three-dimensional (3-D) structure as well as that of individual cells by tissue staining and autofluorescence. In this study, we evaluated intestinal morphology, intestinal epithel
Externí odkaz:
https://doaj.org/article/444c2be1c89a4867a8b89ba4bb7497c6
Autor:
Hisato Tatsuoka, Satoko Sakamoto, Daisuke Yabe, Ryotaro Kabai, Unyanee Kato, Tatsuya Okumura, Ainur Botagarova, Shinsuke Tokumoto, Ryota Usui, Masahito Ogura, Kazuaki Nagashima, Eri Mukai, Yoshio Fujitani, Akira Watanabe, Nobuya Inagaki
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101774- (2020)
Summary: Heterogeneity of gene expression and rarity of replication hamper molecular analysis of β-cell mass restoration in adult pancreas. Here, we show transcriptional dynamics in β-cell replication process by single-cell RNA sequencing of murine
Externí odkaz:
https://doaj.org/article/293e0594aa764c139deac2f241414cca
Publikováno v:
Diabetes. 71
Blood glucose elevates at initial high-dose steroid (HDS) administration and is prolonged by persistent amplification of glucagon-induced glycogenesis. Insulin (INS) administration at initial dose of HDS will avoid this. However, INS administration c
Autor:
Tomonobu Hatoko, Norio Harada, Shinsuke Tokumoto, Shunsuke Yamane, Eri Ikeguchi-Ogura, Tomoko Kato, Takuma Yasuda, Hisato Tatsuoka, Satoko Shimazu-Kuwahara, Daisuke Yabe, Yoshitaka Hayashi, Nobuya Inagaki
Publikováno v:
Scientific reports. 12(1)
Tissue optical clearing permits detailed evaluation of organ three-dimensional (3-D) structure as well as that of individual cells by tissue staining and autofluorescence. In this study, we evaluated intestinal morphology, intestinal epithelial cells
Autor:
Ichiro Tsunematsu, Kazuya Motohashi, Hideo Kita, Shizuka Kaneko, Shinsuke Tokumoto, Hideki Eguchi, Ueba Yoko
Publikováno v:
Diabetes. 70
During the COVID-19 pandemic, Japanese victims number less than in other countries, perhaps due to gene specifics, aspects of Japanese lifestyle and coagulation system characteristics typically less potent in Japanese than in Caucasians. The Osaka pr
Autor:
Yoshitaka Hayashi, Nobuya Inagaki, Daisuke Yabe, Ryota Usui, Hisato Tatsuoka, Yanyan Liu, Shinsuke Tokumoto, Norio Harada, Yu Wang, Kazuyo Suzuki, Shin-ichi Harashima, Daisuke Tanaka
Publikováno v:
The FASEB Journal. 33:6239-6253
Our previous study demonstrated that sphingosine kinase 1-interacting protein (SKIP, or Sphkap) is expressed in pancreatic β-cells, and depletion of SKIP enhances glucose-stimulated insulin secretion. We find here that SKIP is also expressed in inte
Autor:
Shinsuke Tokumoto, Hisato Tatsuoka, Daisuke Yabe, Pedro Luis Herrera, Nobuya Inagaki, Muhammad Fauzi, Ainur Botagarova, Ryota Usui, Masahito Ogura, Hisanori Goto
Publikováno v:
Diabetes
Diabetes (2020) P. db200290
Diabetes (2020) P. db200290
Pancreatic β-cell proliferation has been gaining much attention as a therapeutic target for prevention and treatment of diabetes. In order to evaluate potential β-cell mitogens, accurate and reliable methods for detection and quantification of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b30c59a0a7b826f084e192855c81eb4
https://doi.org/10.2337/figshare.12753533
https://doi.org/10.2337/figshare.12753533
Autor:
Sachiko Honjo, Kanta Fujimoto, Shinsuke Tokumoto, Hiroyuki Koshiyama, Hiroki Ikeda, Yoshiyuki Hamamoto, Yoshiharu Wada
Publikováno v:
Clinical Drug Investigation. 37:845-852
Ultra-long-acting insulin degludec (DEG) has a longer duration of action and less daily variability relative to other basal insulin (BI), and thus may benefit patients with type 1 diabetes mellitus (T1DM). We examined the impact of switching BI to DE
Autor:
Hisanori Goto, Masahito Ogura, Daisuke Yabe, Pedro Luis Herrera, Muhammad Fauzi, Ryota Usui, Nobuya Inagaki, Shinsuke Tokumoto, Ainur Botagarova, Hisato Tatsuoka
SummaryInducing β-cell proliferation could inhibit diabetes progression. Many factors have been suggested as potential β-cell mitogens, but their impact on β-cell replication has not been confirmed due to the lack of a standardized β-cell prolife
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89a4f12029738cbaed0f6ccdf22cdcb
https://doi.org/10.1101/659904
https://doi.org/10.1101/659904
Autor:
Masahito Ogura, Shizuka Kobayashi, Yoshihiro Baba, Shinsuke Tokumoto, Kazuaki Nagashima, Ryota Usui, Nobuya Inagaki, Hisanori Goto, Yumiko Tahara, Hisato Tatsuoka, Muhammad Fauzi, Toshiya Manabe, Daisuke Yabe, Tomohiro Kurosaki, Ainur Botagarova
Publikováno v:
Diabetes. 68
Background: Store-operated Ca2+ entry (SOCE) is activated by endoplasmic reticulum (ER) Ca2+ sensor STIM1 which senses depletion of Ca2+ from the ER, and induces extracellular Ca2+ influx through Orai1 to the cytosol to maintain intracellular Ca2+ ho