Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Shinsuke Niwa"'
Publikováno v:
Communications Physics, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract The mechanisms underlying the chemo-mechanical coupling of motor proteins is usually described by a set of force-velocity relations that reflect the different mechanisms responsible for the walking behavior of such proteins on microtubules.
Externí odkaz:
https://doaj.org/article/bf0ba925da9e4a819f07b3eecf07ae38
Publikováno v:
eLife, Vol 12 (2024)
Kinesin-3 is a family of microtubule-dependent motor proteins that transport various cargos within the cell. However, the mechanism underlying kinesin-3 activations remains largely elusive. In this study, we compared the biochemical properties of two
Externí odkaz:
https://doaj.org/article/72133c87b7da432497a7f49c366bcb89
Autor:
Shinya Taguchi, Juri Nakano, Tsuyoshi Imasaki, Tomoki Kita, Yumiko Saijo-Hamano, Naoki Sakai, Hideki Shigematsu, Hiromichi Okuma, Takahiro Shimizu, Eriko Nitta, Satoshi Kikkawa, Satoshi Mizobuchi, Shinsuke Niwa, Ryo Nitta
Publikováno v:
eLife, Vol 11 (2022)
Kinesin superfamily proteins are microtubule-based molecular motors driven by the energy of ATP hydrolysis. Among them, the kinesin-4 family is a unique motor that inhibits microtubule dynamics. Although mutations of kinesin-4 cause several diseases,
Externí odkaz:
https://doaj.org/article/7e036509e52e42ebb8bcf2b69ed29cfd
Autor:
Tsuyoshi Imasaki, Satoshi Kikkawa, Shinsuke Niwa, Yumiko Saijo-Hamano, Hideki Shigematsu, Kazuhiro Aoyama, Kaoru Mitsuoka, Takahiro Shimizu, Mari Aoki, Ayako Sakamoto, Yuri Tomabechi, Naoki Sakai, Mikako Shirouzu, Shinya Taguchi, Yosuke Yamagishi, Tomiyoshi Setsu, Yoshiaki Sakihama, Eriko Nitta, Masatoshi Takeichi, Ryo Nitta
Publikováno v:
eLife, Vol 11 (2022)
Microtubules are dynamic polymers consisting of αβ-tubulin heterodimers. The initial polymerization process, called microtubule nucleation, occurs spontaneously via αβ-tubulin. Since a large energy barrier prevents microtubule nucleation in cells
Externí odkaz:
https://doaj.org/article/d32eeac96c0645ad83b454410aa41fe9
Autor:
Kumiko Hayashi, Shinsuke Niwa
Publikováno v:
Biophysics and Physicobiology, Vol 18 (2021)
Externí odkaz:
https://doaj.org/article/cab6ba5adb3f49eca6c2583a5d80eb86
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Proper intracellular trafficking is essential for neuronal development and function, and when any aspect of this process is dysregulated, the resulting “transportopathy” causes neurological disorders. Hereditary spastic paraplegias (HSPs) are a f
Externí odkaz:
https://doaj.org/article/c239d39b6b4d4e3d8bac0ccb42c3c98f
Autor:
Shinsuke Niwa, David M. Lipton, Manatsu Morikawa, Charles Zhao, Nobutaka Hirokawa, Hang Lu, Kang Shen
Publikováno v:
Cell Reports, Vol 16, Iss 8, Pp 2129-2141 (2016)
Kinesin motor proteins transport intracellular cargoes throughout cells by hydrolyzing ATP and moving along microtubule tracks. Intramolecular autoinhibitory interactions have been shown for several kinesins in vitro; however, the physiological signi
Externí odkaz:
https://doaj.org/article/54dfcd7cd3624f62b8129cd2abdf3e49
Autor:
Poh Hui Chia, Franklin Lei Zhong, Shinsuke Niwa, Carine Bonnard, Kagistia Hana Utami, Ruizhu Zeng, Hane Lee, Ascia Eskin, Stanley F Nelson, William H Xie, Samah Al-Tawalbeh, Mohammad El-Khateeb, Mohammad Shboul, Mahmoud A Pouladi, Mohammed Al-Raqad, Bruno Reversade
Publikováno v:
eLife, Vol 7 (2018)
Calcium/calmodulin-dependent protein kinase II (CAMK2) plays fundamental roles in synaptic plasticity that underlies learning and memory. Here, we describe a new recessive neurodevelopmental syndrome with global developmental delay, seizures and inte
Externí odkaz:
https://doaj.org/article/db6a2998912a4cdc9e37796ad1f08f29
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197128 (2018)
Studies on Caenorhabditis elegans would benefit from the introduction of new selectable markers to allow more complex types of experiments to be conducted with this model animal. We established a new antibiotic selection marker for C. elegans transfo
Externí odkaz:
https://doaj.org/article/6b7ef2f091024024951e58bacb907f84
Publikováno v:
Cell Reports, Vol 3, Iss 2, Pp 509-519 (2013)
Molecular motors are fundamental to neuronal morphogenesis and function. However, the extent to which molecular motors are involved in higher brain functions remains largely unknown. In this study, we show that mice deficient in the kinesin family mo
Externí odkaz:
https://doaj.org/article/a898b79716b14834acebe3f287bb4af4