Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Shinsuke Hiki"'
Autor:
Adachi Takashi, Narihiko Yoshii, Kazutoshi Watanabe, Fumiaki Uehara, Mika Nabeno, Takashi Horikawa, Kenji Fukunaga, Ken-Ichi Saito, Shinji Sunada, Satoshi Yokoshima, Shinji Tanaka, Satoshi Yuki, Shouichi Asano, Aya Shouda, Hiroshi Tanaka, Shinsuke Hiki, Keiichi Aritomo, Masatake Fujimura, Keiji Yamagami, Yoshihiro Usui, Jun-ichi Eguchi
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(16)
We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 2-phenylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15af65e99a9d19a8f0c2d46937023c5e
https://pubmed.ncbi.nlm.nih.gov/28712708
https://pubmed.ncbi.nlm.nih.gov/28712708
Autor:
Jun-ichi Eguchi, Shinsuke Hiki, Masatake Fujimura, Satoshi Yuki, Shinji Sunada, Tokushi Hanano, Masahiro Okuyama, Fumiaki Uehara, Toshiyuki Kohara, Hiroshi Tanaka, Keiichi Aritomo, Susumu Tsuchiya, Ken-Ichi Saito, Kenji Fukunaga, Kazutoshi Watanabe, Shoichi Asano, Koichi Yamakoshi, Hiroshi Baba, Shinji Tanaka, Takashi Horikawa, Yoshihiro Usui, Aya Shoda, Akiko Mori, Keiji Yamagami
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6933-6937
A series of 2-(2-phenylmorpholin-4-yl)pyrimidin-4(3H)-ones was synthesized and examined for their inhibitory activity against glycogen synthase kinase-3β (GSK-3β). We found 21, 29 and 30 to possess potent in vitro GSK-3β inhibitory activity with g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a885218d2050bd32f637b9c4aaa1822
https://doi.org/10.1016/j.bmcl.2013.09.020
https://doi.org/10.1016/j.bmcl.2013.09.020
Autor:
Toshio Kumagai, Chisato Sato, Takao Abe, Satoshi Tamai, Shinsuke Hiki, Kazuhiko Hayashi, Yoshimitsu Nagao
Publikováno v:
Tetrahedron Letters. 40:3761-3764
1-Azabicyclo[1.1.0]butane 2 was successfully synthesized by treatment of 2,3-dibromopropylamine hydrobromide 4 with organolithium compounds and was readily converted to 1-(1,3-thiazolin-2-yl)azetidine-3-thiol hydrochloride 1 and versatile azetidine d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4e193db4c608e870c239a2c088effc6
https://doi.org/10.1016/s0040-4039(99)00603-6
https://doi.org/10.1016/s0040-4039(99)00603-6
Publikováno v:
ChemInform. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73380941a55553660d4e159d4974b55b
https://doi.org/10.1002/chin.200222115
https://doi.org/10.1002/chin.200222115
Publikováno v:
HETEROCYCLES. 56:433
A THF solution of l-azabicyclo[1.1.0]butane (2), obtained from 2,3-dibromopropylamine hydrobromide (1), was treated with HCl-EtOH, 48% HBr, ClCO 2 Et, Ts 2 O, HCO 2 H - 2.7N HCl-MeOH, or Ac 2 O - 3N HCl to give the corresponding 3-monosubstituted and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::232320101f181b2fc953d3a6f20991e6
https://doi.org/10.3987/com-01-s(k)65
https://doi.org/10.3987/com-01-s(k)65