Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Shinsuke Araki"'
Autor:
Masato Yugami, Yoshika Hayakawa-Yano, Takahisa Ogasawara, Kazumasa Yokoyama, Takako Furukawa, Hiroe Hara, Kentaro Hashikami, Isamu Tsuji, Hirohide Takebayashi, Shinsuke Araki, Hideyuki Okano, Masato Yano
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108451- (2023)
Summary: Oligodendrocytes (OLs) are the myelin-forming cells in the CNS that support neurons through the insulating sheath of axons. This unique feature and developmental processes are achieved by extrinsic and intrinsic gene expression programs, whe
Externí odkaz:
https://doaj.org/article/d74c3833c99a4893987ac67d95cb9c23
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Accumulating evidence has indicated that pre-mRNA splicing plays critical roles in a variety of physiological processes, including development of multiple diseases. In particular, alternative splicing is profoundly involved in cancer progression thro
Externí odkaz:
https://doaj.org/article/c21bb2b1bacd4e879afd3fc7e4a56305
Autor:
Momoko Ohori, Yusuke Nakayama, Mari Ogasawara-Shimizu, Hiroyoshi Toyoshiba, Atsushi Nakanishi, Samuel Aparicio, Shinsuke Araki
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background Endothelial cell senescence is the state of permanent cell cycle arrest and plays a critical role in the pathogenesis of age-related diseases. However, a comprehensive understanding of the gene regulatory network, including genome
Externí odkaz:
https://doaj.org/article/8a3ccdb38a2246d8b51530ba78db631f
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Since chimeric antigen receptor (CAR) T-cell therapies for hematologic malignancies were approved by the U.S. Food and Drug Administration, numerous “next-generation” CAR T cells have been developed to improve their safety, efficacy, and applicab
Externí odkaz:
https://doaj.org/article/fa6277b576d24343a32bde65a2d978a3
Synergistic apoptotic effects in cancer cells by the combination of CLK and Bcl-2 family inhibitors.
Autor:
Aiko Murai, Shunsuke Ebara, Satoshi Sasaki, Tomohiro Ohashi, Tohru Miyazaki, Toshiyuki Nomura, Shinsuke Araki
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240718 (2020)
Emerging evidence indicates that alternative splicing plays a critical role in cancer progression through abnormal expression or mutation of splicing factors. Small-molecule splicing modulators have recently attracted considerable attention as a nove
Externí odkaz:
https://doaj.org/article/d70071ab62df463cb60eee743a603d5b
Autor:
Tyler Funnell, Shinya Tasaki, Arusha Oloumi, Shinsuke Araki, Esther Kong, Damian Yap, Yusuke Nakayama, Christopher S. Hughes, S.-W. Grace Cheng, Hirokazu Tozaki, Misa Iwatani, Satoshi Sasaki, Tomohiro Ohashi, Tohru Miyazaki, Nao Morishita, Daisuke Morishita, Mari Ogasawara-Shimizu, Momoko Ohori, Shoichi Nakao, Masatoshi Karashima, Masaya Sano, Aiko Murai, Toshiyuki Nomura, Noriko Uchiyama, Tomohiro Kawamoto, Ryujiro Hara, Osamu Nakanishi, Karey Shumansky, Jamie Rosner, Adrian Wan, Steven McKinney, Gregg B. Morin, Atsushi Nakanishi, Sohrab Shah, Hiroyoshi Toyoshiba, Samuel Aparicio
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The phosphorylation of serine/arginine-rich proteins by CDC-like kinase is a central regulatory mechanism for RNA splicing reactions. Here, the authors synthesize a novel small molecule CLK inhibitor and map CLK-responsive alternative splicing events
Externí odkaz:
https://doaj.org/article/5aad2179e7e647afa20357dc81dea1bc
Autor:
Shinsuke Araki, Ryo Dairiki, Yusuke Nakayama, Aiko Murai, Risa Miyashita, Misa Iwatani, Toshiyuki Nomura, Osamu Nakanishi
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0116929 (2015)
Accumulating evidence has demonstrated the importance of alternative splicing in various physiological processes, including the development of different diseases. CDC-like kinases (CLKs) and serine-arginine protein kinases (SRPKs) are components of t
Externí odkaz:
https://doaj.org/article/c03c65d55d8948bcbcc348848340aa05
Autor:
Ryushin Mizuta, Shinsuke Araki, Makoto Furukawa, Yuki Furukawa, Syota Ebara, Daisuke Shiokawa, Katsuhiko Hayashi, Sei-ichi Tanuma, Daisuke Kitamura
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e80223 (2013)
Apoptosis and necrosis, two major forms of cell death, can be distinguished morphologically and biochemically. Internucleosomal DNA fragmentation (INDF) is a biochemical hallmark of apoptosis, and caspase-activated DNase (CAD), also known as DNA frag
Externí odkaz:
https://doaj.org/article/a23727df6fcc41cfba0a04177ec0ccc6
Autor:
Toshio Tanaka, Tomohiro Kawamoto, Satoshi Endo, Samuel Aparicio, Michiko Tawada, Atsushi Nakanishi, Momoko Ohori, Douglas R. Cary, Masahiro Ito, Masahiro Nogami, Toshihiro Imaeda, Misa Iwatani, Shinsuke Araki, Shoichi Nakao, Yasuhiro Imaeda
Publikováno v:
Biochemical and Biophysical Research Communications. 523:795-801
The DEAD-box family of RNA helicases plays essential roles in both transcriptional and translational mRNA degradation; they unwind short double-stranded RNA by breaking the RNA-RNA interactions. Two DEAD-box RNA helicases, eukaryotic translation init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92b4a687affd66801c43aa881d530cd
https://doi.org/10.1016/j.bbrc.2019.12.094
https://doi.org/10.1016/j.bbrc.2019.12.094
Autor:
Noriyoshi Nakamura, Sachiyo Nomura, Takeshi Hirano, Fumiko Yamaguchi, Shinsuke Araki, Masatsugu Kamei, Kazuya Nonaka, Tomonari Takaki, Kazuhito Kugimoto, Kenji Tokushige, Toshihiko Higashijima
Publikováno v:
Chagyo Kenkyu Hokoku (Tea Research Journal). 2019:9-21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c09419a5276185fb44d253bb49aae76e
https://doi.org/10.5979/cha.2019.128_9
https://doi.org/10.5979/cha.2019.128_9