Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway

Autor: Hsu-Wen Chao, Masao Doi, Jean-Michel Fustin, Huatao Chen, Kimihiko Murase, Yuki Maeda, Hida Hayashi, Rina Tanaka, Maho Sugawa, Naoki Mizukuchi, Yoshiaki Yamaguchi, Jun-ichirou Yasunaga, Masao Matsuoka, Mashito Sakai, Michihiro Matsumoto, Shinshichi Hamada, Hitoshi Okamura

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Circadian clock regulates hepatic gene expression and functions. Here Chao et al. show that alteration of circadian clock genes by Period deletion induces polyploidy in hepatocytes due to impaired regulation of Erk signaling by mitogen-activated prot

Externí odkaz: https://doaj.org/article/00c4c91b8a014bdc961074b75b4bbb0b

Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway

Autor: Michihiro Matsumoto, Maho Sugawa, Hitoshi Okamura, Jun-ichirou Yasunaga, Hida Hayashi, Huatao Chen, Rina Tanaka, Shinshichi Hamada, Jean-Michel Fustin, Naoki Mizukuchi, Yoshiaki Yamaguchi, Yuki Maeda, Masao Doi, Hsu Wen Chao, Masao Matsuoka, Mashito Sakai, Kimihiko Murase

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Chao, HW, Doi, M, Fustin, JM, Chen, H, Murase, K, Maeda, Y, Hayashi, H, Tanaka, R, Sugawa, M, Mizukuchi, N, Yamaguchi, Y, Yasunaga, JI, Matsuoka, M, Sakai, M & Okamura, H 2017, ' Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway. ', Nature Communications . https://doi.org/10.1038/s41467-017-02207-7
Nature Communications

Liver metabolism undergoes robust circadian oscillations in gene expression and enzymatic activity essential for liver homeostasis, but whether the circadian clock controls homeostatic self-renewal of hepatocytes is unknown. Here we show that hepatoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5904109c1230b85a1eaf950cdfde913
https://doaj.org/article/00c4c91b8a014bdc961074b75b4bbb0b

A Case of Adenocarcinoma Arising from an Ectopic Pancreas of the Stomach Presented with Pyloric Stenosis

Autor: Ken Yanagibashi, Sato Suzaki, Akira Mitsuyoshi, Naoko Masuzawa, Shinshichi Hamada, Tsuyoshi Tachibana, Masayuki Nakau, Seiji Yanai

Publikováno v: Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association). 76:37-42

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9ab5ede171c273f73a263d630a27c04
https://doi.org/10.3919/jjsa.76.37

Adjuvant combined paclitaxel and carboplatin chemotherapy for glassy cell carcinoma of the uterine cervix: Report of three cases with clinicopathological analysis

Autor: Haruta Mogami, Shinshichi Hamada, Ikuo Konishi, Yoshiki Takahashi, Hiroe Sasaki

Publikováno v: Journal of Obstetrics and Gynaecology Research. 37:1860-1863

Glassy cell carcinoma of the uterine cervix (GCC) is a rare form of cervical carcinoma that is characterized by aggressiveness and poor prognosis. We reviewed a variety of clinicopathological features, treatment strategies, and outcomes in three wome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07614cfd5c0fa3202d787013c11edc85
https://doi.org/10.1111/j.1447-0756.2011.01643.x

Pathogenic mechanisms of intestinal pneumatosis and portal venous gas: should patients with these conditions be operated immediately?

Autor: Tsuyoshi Tachibana, Ken Yanagibashi, Daiju Yokoyama, Hiroshi Okabe, Yuhei Kondo, Akira Mitsuyoshi, Sato Suzaki, Shinshichi Hamada, Teppei Momono, Masayuki Nakau, Hiroki Aoyama, Kenta Inoguchi

Publikováno v: Surgical Case Reports

We aimed to histologically observe portal venous gas (PVG)-causing intestinal pneumatosis (IP) and evaluate pathogenic mechanisms and therapeutic strategies, including decisions on whether emergency surgery should be performed. Autopsy was performed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7633be277f518254f40ccefdc321b446
https://doi.org/10.1186/s40792-015-0104-7