Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Shinsaku Hirosawa"'
Autor:
Shinsaku Hirosawa
Publikováno v:
International journal of hematology. 73(2)
Publikováno v:
British Journal of Haematology. 89:893-896
We report an unusual case of a 74-year-old male who developed a serum autoantibody reactive with human coagulation factor V (FV) in an activated form, as demonstrated by coagulation studies and immunoblotting analysis. Despite marked prolongation of
Publikováno v:
Laboratory Investigation. 87:540-547
An essential coagulation factor, tissue factor (TF), is rapidly expressed by human monocytes when exposed to a variety of agonists, such as lipopolysaccharide or tumor necrosis factor (TNF). We previously found that 1alpha,25-dihydroxyvitamin D(3) (1
Autor:
Noriyuki Tabuchi, Makoto Sunamori, Fumie Nakazawa, Takatoshi Koyama, Aya Shibamiya, Jihwa Chung, Shinsaku Hirosawa, Masayoshi Shichiri
Publikováno v:
European Journal of Cardio-Thoracic Surgery. 26:995-1001
Objective: Immediate loss of thrombomodulin activity in the endothelium of vein grafts has been demonstrated during 90 min exposure to arterial circulation; this loss of activity is ascribed as an important cause of early thrombosis. Conventional ex
Autor:
Shinsaku Hirosawa, Aya Shibamiya, Takatoshi Koyama, Fumie Nakazawa, Miwako Nishio, Masako Nakahara
Publikováno v:
Thrombosis and Haemostasis. 92:1284-1290
SummaryProteins that fail to attain their correct three-dimensional structure are retained in the endoplasmic reticulum (ER) and eventually degraded within the cells. We investigated the degradation of mutant proteins, using naturally occurring prote
Publikováno v:
Thrombosis Research. 112:313-320
Tissue factor (TF) is expressed rapidly by human monocytes exposed to a variety of agonists such as lipopolysaccharide (LPS) or tumor necrosis factor-alpha. Activation of both activator protein-1 (AP-1; c-Jun/c-Fos) and nuclear factor-kappaB (NF-kapp
Autor:
Masako Nakahara, Nobuo Aoki, Fumie Nakazawa, Aya Shibamiya, Haruhiko Yoshinaga, Shinsaku Hirosawa, Takatoshi Koyama, Lindsey A. Miles
Publikováno v:
Thrombosis and Haemostasis. 88:144-148
SummaryPlasma plasmin inhibitor (PI) is a physiological inhibitor of plasminmediated fibrinolysis and constitutes a hemostatic component in blood plasma; hence its deficiency results in a severe hemorrhagic diathesis. We have carried out molecular an
Autor:
Keiko Yamamoto, Mai Ohsawa, Sachiko Kamei, Takatoshi Koyama, Shinsaku Hirosawa, Ryuichi Kamiyama
Publikováno v:
Circulation. 102:2867-2872
Background —We have recently found that a hormonally active form of vitamin D, 1α,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ], exerts anticoagulant effects by upregulating the expression of an anticoagulant glycoprotein, thrombomodulin (TM), and dow
Autor:
Dong Hui Chung, Ryuichi Kamiyama, Takatoshi Koyama, Haruhiko Yoshinaga, Takako Saito, Shinsaku Hirosawa, Fumie Nakazawa, Misako Shibakura
Publikováno v:
British Journal of Haematology. 106:416-420
Thrombomodulin (TM) is an endothelial cell glycoprotein that acts as an anticoagulant. Mutation in the TM gene is a potential risk factor for thrombosis. The first TM mutation identified was a heterozygous substitution of T for G at nucleotide positi
Autor:
Ryuichi Kamiyama, Osamu Miura, Fumi Shibata, Koh Yamamoto, Shinsaku Hirosawa, Nobuyuki Miyasaka
Publikováno v:
Biochemical and Biophysical Research Communications. 257:400-404
IL-12 is a heterodimeric cytokine, composed of p40 and p35 subunits, that exerts its biological effects by binding to specific cell surface receptors. Two human IL-12 receptor proteins, designated IL-12R beta 1 and IL-12R beta 2, have been previously