Zobrazeno 1 - 10
of 323
pro vyhledávání: '"Shinsaku, Nakagawa"'
Autor:
Kotaro Sakamoto, Seigo Iwata, Zihao Jin, Lu Chen, Tatsunori Miyaoka, Mei Yamada, Kaiga Katahira, Rei Yokoyama, Ami Ono, Satoshi Asano, Kotaro Tanimoto, Rika Ishimura, Shinsaku Nakagawa, Takatsugu Hirokawa, Yukio Ago, Eijiro Miyako
Publikováno v:
JACS Au, Vol 4, Iss 8, Pp 2811-2817 (2024)
Externí odkaz:
https://doaj.org/article/aa113cdf44a34434ada51d6d3b16c4ca
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Mutations in the cell proliferation regulator K-Ras are found with a variety of cancer types, so drugs targeting these mutant proteins could hold great clinical potential. Very recently, a drug targeting the K-Ras(G12C) mutant observed in lu
Externí odkaz:
https://doaj.org/article/56478475c00642258083c3d1b2b3db27
Autor:
Kotaro Sakamoto, Wararat Kittikulsuth, Eijiro Miyako, Akumwami Steeve, Rika Ishimura, Shinsaku Nakagawa, Yukio Ago, Akira Nishiyama
Publikováno v:
PLoS ONE, Vol 18, Iss 7, p e0286651 (2023)
We have previously demonstrated that KS-133 is a specific and potent antagonist of vasoactive intestinal peptide receptor 2 (VIPR2). We have also shown that vasoactive intestinal peptide-VIPR2 signaling affects the polarity and activation of tumor-as
Externí odkaz:
https://doaj.org/article/a57ed84627954eb3bb7a0cca4207452b
Autor:
Toshiko Yamazawa, Takuya Kobayashi, Nagomi Kurebayashi, Masato Konishi, Satoru Noguchi, Takayoshi Inoue, Yukiko U. Inoue, Ichizo Nishino, Shuichi Mori, Hiroto Iinuma, Noriaki Manaka, Hiroyuki Kagechika, Arkady Uryash, Jose Adams, Jose R. Lopez, Xiaochen Liu, Christine Diggle, Paul D. Allen, Sho Kakizawa, Keigo Ikeda, Bangzhong Lin, Yui Ikemi, Kazuto Nunomura, Shinsaku Nakagawa, Takashi Sakurai, Takashi Murayama
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mutations in ryanodine receptor 1 (RyR1), a Ca2+ release channel in skeletal muscle, cause malignant hyperthermia (MH) and are involved in heat stroke. Here, the authors show that an oxolinic acid-derivative RyR1 inhibitor effectively prevents and tr
Externí odkaz:
https://doaj.org/article/afd2999f767e49b494c83b5f5e5c1a4b
Autor:
Kenji Ishimoto, Yukiko Shimada, Akane Ohno, Shuichi Otani, Yukio Ago, Soya Maeda, Bangzhong Lin, Kazuto Nunomura, Nobumasa Hino, Masayuki Suzuki, Shinsaku Nakagawa
Publikováno v:
Frontiers in Nutrition, Vol 9 (2022)
Naringenin (NRG) is a plant-derived flavonoid. Due to its antioxidant, anti-inflammatory, and analgesic activities it is beneficial to human health and is often used as a functional food ingredient; however, it has poor water solubility and low in vi
Externí odkaz:
https://doaj.org/article/b7424a9db63f42ec8bfe887aae0c95ae
Autor:
Kotaro Sakamoto, Lu Chen, Tatsunori Miyaoka, Mei Yamada, Teruaki Masutani, Kenji Ishimoto, Nobumasa Hino, Shinsaku Nakagawa, Satoshi Asano, Yukio Ago
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Worldwide, more than 20 million people suffer from schizophrenia, but effective and definitive new therapeutic drugs/treatments have not been established. Vasoactive intestinal peptide receptor 2 (VIPR2) might be an attractive drug target for the tre
Externí odkaz:
https://doaj.org/article/a48f0731bf1640b887ab23400b1a5cfb
Autor:
Shuto Takeuchi, Takuya Kawanai, Ryosuke Yamauchi, Lu Chen, Tatsunori Miyaoka, Mei Yamada, Satoshi Asano, Atsuko Hayata-Takano, Takanobu Nakazawa, Koji Yano, Naotaka Horiguchi, Shinsaku Nakagawa, Kazuhiro Takuma, James A. Waschek, Hitoshi Hashimoto, Yukio Ago
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Clinical studies have shown that microduplications at 7q36.3, containing VIPR2, confer significant risk for schizophrenia and autism spectrum disorder (ASD). VIPR2 gene encodes the VPAC2 receptor for vasoactive intestinal peptide (VIP) and pituitary
Externí odkaz:
https://doaj.org/article/5aacf9b8b65c485995cafa3a29a95fc0
Autor:
Toshihiko Matsuo, Shihui Liu, Tetsuya Uchida, Satomi Onoue, Shinsaku Nakagawa, Mayumi Ishii, Kayoko Kanamitsu
Publikováno v:
Life, Vol 11, Iss 6, p 591 (2021)
NK-5962 is a key component of photoelectric dye-based retinal prosthesis (OUReP). In testing the safety and efficacy, NK-5962 was safe in all tests for the biological evaluation of medical devices (ISO 10993) and effective in preventing retinal cells
Externí odkaz:
https://doaj.org/article/9984418e4ac847389c1f7519c25ffd6d
Autor:
Keigo Hirai, Hiroko Yamashita, Shusuke Tomoshige, Yugo Mishima, Tatsuya Niwa, Kenji Ohgane, Mayumi Ishii, Kayoko Kanamitsu, Yui Ikemi, Shinsaku Nakagawa, Hideki Taguchi, Shinichi Sato, Yuichi Hashimoto, Minoru Ishikawa
Publikováno v:
ACS Med Chem Lett
[Image: see text] The onset of neurodegenerative disorders (NDs), such as Alzheimer’s disease, is associated with the accumulation of aggregates of misfolded proteins. We previously showed that chemical knockdown of ND-related aggregation-prone pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4266d295c5c976a524cca1b418d2752f
https://doi.org/10.1021/acsmedchemlett.1c00500
https://doi.org/10.1021/acsmedchemlett.1c00500
Autor:
Kenji Ishimoto, Yuma Konishi, Shuichi Otani, Soya Maeda, Yukio Ago, Nobumasa Hino, Masayuki Suzuki, Shinsaku Nakagawa
Publikováno v:
Journal of Natural Medicines.
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44cfea0b0e33776f0b27efe128a79ee8
https://hdl.handle.net/11094/90087
https://hdl.handle.net/11094/90087