Výsledky vyhledávání - "Shinobu GUNJI"

Bioanalysis works in the IAA AMS facility: Comparison of AMS analytical method with LSC method in human mass balance study

Autor: Yoshimi Isono, Kumiko Sakai, Kaoru Setani, Ichimaro Yamada, Shinobu Gunji, Yoshiaki Sato, Takao Matsui, Teiji Miyaoka

Publikováno v: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 259:779-785

Institute of Accelerator Analysis Ltd. (IAA) is the first Contract Research Organization in Japan providing Accelerator Mass Spectrometry (AMS) analysis services for carbon dating and bioanalysis works. The 3 MV AMS machines are maintained by validat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2362d6a0345e9f1d8e8acd0dfdca361c
https://doi.org/10.1016/j.nimb.2007.02.001

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Studies on the Metabolic Fate of Amrubicin Hydrochloride (SM-5887), a Novel Antitumor Agent. (I): Blood Concentration, Distribution, Metabolism and Excretion after a Single Intravenous Administration to Rats

Autor: Shunji NAKAI, Kyoko AKAO, Masaki ITO, Yoshiko MIZUNO, Setsuko KOMURO, Hiroshi KANAMARU, Iwao NAKATSUKA, Yoshio ESUMI, Masao ISHIZAKI, Shinobu GUNJI, Atsushi TAKAO, Kazue KIMURA, Tomoko NAKAYAMA, Shinichi NINOMIYA

Publikováno v: Drug Metabolism and Pharmacokinetics. 13:61-77

Pharmacokinetics on plasma and blood cells concentration, tissue distribution and excretion of amrubicin hydrochloride (SM-5887), a novel antitumor agent, were investigated after a single intravenous administration of 14C-labeled SM-5887 at the doses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbdbd9ad00e8df4ebccfbd9e0322f337
https://doi.org/10.2133/dmpk.13.61

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Metabolic Fate of Clonidine. (V): Metabolism of Clonidine after Subcutaneous Administration of Clonidine to Rats, Dogs and Monkeys and Dermal Application of Clonidine Tape, M-5041T, to Rats

Autor: Masao Ishizaki, Shinobu Gunji, Yoshitaka Jin, Yuichi Okamura, Manami Taguchi, Hitoshi Nishikawa, Yoshio Esumi, Shin-ichi Ninomiya, Ryuichi Kohno, Yasuo Minaki, Hiromi Muto, Shigeya Okada, Tohru Yamahata

Publikováno v: Drug Metabolism and Pharmacokinetics. 11:411-420

The metabolism of clonidine in rats, dogs and monkeys was investigated after subcutaneous administration of 14C-clonidine or after application of a transdermal delivery system containing 14C-clonidine, 14C-M-5041T. 1. In male rats after subcutaneous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a035e665bd700a5dbcea6fce1e6805cb
https://doi.org/10.2133/dmpk.11.411

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Metabolic Fate of Ritipenem Acoxil (2): Absorption, Distribution, Metabolism and Excretion in Rats After Repeated Administration

Autor: Hideaki Seki, Satoru Kimura, Shin-ichi Ninomiya, Masanori Hatsuoka, Shinobu Gunji, Yoshio Esumi, Masayoshi Tanaka, Katsumi Uohama

Publikováno v: Drug Metabolism and Pharmacokinetics. 11:178-187

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de19effb6a52d5e569bc81b3344e3884
https://doi.org/10.2133/dmpk.11.178

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Metabolic Fate of YNK01. (1). Absorption, Distribution, Metabolism and Excretion after Single Administration of (14C) YNK01 to Rats

Autor: Yoshitaka Jin, Matsuo Takaichi, Shinobu Gunji, Sachiko Takiie, Yumiko Nakagawa, Hidemasa Seki, Manami Morozumi, Kumiko Kouno, Hideki Takayama, Yoshio Esumi, Hisashi Ochiai, Chizuko Matsuura

Publikováno v: Drug Metabolism and Pharmacokinetics. 8:1229-1239

Absorption, distribution, metabolism and excretion of [14C] 4-amino-1-β-D-arabinofuranosyl-2 (1H)-pyrimidinone 5'-(sodium octadecyl phosphate) monohydrate (YNK01) were studied in rats after single oral administration of 25mg/kg. 1. Blood concentrati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd380703fe632de6e3414509a5ef4123
https://doi.org/10.2133/dmpk.8.1229

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Studies on the Metabolic Fate of CPT-11. (7): Pharmacokinetics in Rats following Consecutive Intravenous Doses

Autor: Wataru Suzuki, Shin-ichi Ninomiya, Hideo Hakusui, Junji Shimazaki, Ryo Atsumi, Yoshitaka Jin, Syuichirou Tsutsumi, Shinobu Gunji, Yoshio Esumi

Publikováno v: Drug Metabolism and Pharmacokinetics. 6:169-183

Pharmacokinetic studies on blood level, tissue distribution and excretion of CPT-11, a new antitumor agent, were performed in rats during and after the consecutive intravenous administration of 14C-CPT-11 at a daily dose of 4mg/kg for 15 days.1. Bloo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ccc71f73401260ce5199250161bcc27
https://doi.org/10.2133/dmpk.6.169

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Studies on the Metabolic Fate of CPT-11. (3): Pharmacokinetics in Rats following a single intravenous administration of 14C-CPT-11 (PP)

Autor: Wataru Suzuki, Ryo Atsumi, Shinobu Gunji, Yoshio Esumi, Hideo Hakusui, Junko Ogiya, Mayumi Takahashi, Yoshitaka Jin, Hisako Ishikawa

Publikováno v: Drug Metabolism and Pharmacokinetics. 6:105-125

Pharmacokinetic studies on time-course in the blood, tissue distribution, excretion and metabolism of CPT-11, a new anti-cancer agent, were performed in rats following a single intravenous administration of 14C-CPT-11 (PP) at a dose of 10mg/kg.1. Pip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4027911fae893cf66926a9d6e35717a9
https://doi.org/10.2133/dmpk.6.105

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