Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Shino Nemoto"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7203 (2024)
Hydronephrosis, the dilation of kidneys due to abnormal urine retention, occurs spontaneously in certain inbred mouse strains. In humans, its occurrence is often attributed to acquired urinary tract obstructions in adults, whereas in children, it can
Externí odkaz:
https://doaj.org/article/5c975b52fafd4abf9996cfc86b177df6
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract We aimed to identify gut microbiota that influences body weight by elucidating the association with diets and host genes. Germ-free (GF) mice with and without fecal microbiota transplant (FMT) were fed a normal, high-carbohydrate, or high-fa
Externí odkaz:
https://doaj.org/article/740360fe033743719c246d7f73d53a45
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0271651 (2022)
C57BL/6J (B6J) and C57BL/6N (B6N) mice are the most frequently used substrains in C57BL/6 (B6) inbred mice, serving as physiological models for in vivo studies and as background strains to build transgenic mice. However, the differences in metabolic
Externí odkaz:
https://doaj.org/article/a9e67281dbf0466ca1f80fc7836ed433
We aimed to identify gut microbiota that influences body weight by elucidating the association with diets and host genes. Germ-free (GF) mice with and without fecal microbiota transplant (FMT) were fed a normal, high-carbohydrate, or high-fat diet. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37011e6e9a3c6ceaf68171ceb3e8fad7
https://doi.org/10.21203/rs.3.rs-2329358/v1
https://doi.org/10.21203/rs.3.rs-2329358/v1
Autor:
Jiandong Chen, Xinghua Hou, Chuangui Wang, Toren Finkel, Lihong Chen, Neha Kabra, Shino Nemoto, Zhenyu Li, W. Douglas Cress, Yihong Ma, Wei Gu
Publikováno v:
Nature Cell Biology. 8:1025-1031
The nicotinamide adenine dinucleotide (NAD)-dependent deacetylase Sir2 (silent information regulator 2) regulates gene silencing in yeast and promotes lifespan extension during caloric restriction. The mammalian homologue of Sir2 (SirT1) regulates p5
Publikováno v:
Science. 306:2105-2108
Nutrient availability regulates life-span in a wide range of organisms. We demonstrate that in mammalian cells, acute nutrient withdrawal simultaneously augments expression of the SIRT1 deacetylase and activates the Forkhead transcription factor Foxo
Autor:
Toren Finkel, Shino Nemoto
Publikováno v:
Nature. 429:149-152
What determines how long we will live? Studies of simple organisms, single cells and mammals hint that certain shared principles underlie ageing, and raise the possibility of devising ways to extend life — if we want to.
Publikováno v:
Molecular and Cellular Biology. 18:3518-3526
c-Jun N-terminal protein kinase (JNK) and p38, two distinct members of the mitogen-activated protein (MAP) kinase family, regulate gene expression in response to various extracellular stimuli, yet their physiological functions are not completely unde
Publikováno v:
Journal of Biological Chemistry. 272:24751-24754
c-Jun NH2-terminal protein kinase (JNK), a distant member of the mitogen-activated protein (MAP) kinase family, regulates gene expression in response to various extracellular stimuli. JNK is activated by JNK-activating kinase 1 (JNKK1), a dual specif
Publikováno v:
Journal of Nutritional Science and Vitaminology. 43:297-309
This study showed that the inhibition of cell growth in 3T6, induced by the supplementation of ascorbate at 0.5mM in cultured medium, was prevented by the addition of catalase in the range of 25-750 units/mL regardless of the degree of activity. Howe