Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Shino Kuramoto"'
Autor:
Toshiya Ito, Kazutomo Kinoshita, Masaki Tomizawa, Shojiro Shinohara, Hiroki Nishii, Masayuki Matsushita, Kazuo Hattori, Yasunori Kohchi, Masami Kohchi, Tadakatsu Hayase, Fumio Watanabe, Kiyoshi Hasegawa, Hiroshi Tanaka, Shino Kuramoto, Kenji Takanashi, Nobuhiro Oikawa
Publikováno v:
Journal of Medicinal Chemistry. 65:12427-12444
Kinase fusions involving tropomyosin receptor kinases (TRKs) have been proven to act as strong oncogenic drivers and are therefore recognized as attractive therapeutic targets. We screened an in-house kinase-focused library and identified a promising
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ca68dbd017708581343a3a344733b1
https://doi.org/10.1021/acs.jmedchem.2c01099
https://doi.org/10.1021/acs.jmedchem.2c01099
Autor:
Yuko Aoki, Osamu Kondoh, Nobuya Ishii, Toshikazu Yamazaki, Yasushi Yoshimura, Keiichi Morita, Shino Kuramoto, Hirosato Ebiike, Jun Ohwada, Yukako Tachibana, Kiyoaki Sakata, Toshihiko Fujii, Hiromi Tanimura, Miyuki Yoshida, Hiroshi Tanaka
Purpose: The phosphatidylinositol 3-kinase (PI3K) pathway plays a central role in cell proliferation and survival in human cancer. PIK3CA mutations, which are found in many cancer patients, activate the PI3K pathway, resulting in cancer development a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662c38c75e05cc99955bf88044ca940c
https://doi.org/10.1158/1078-0432.c.6518331.v1
https://doi.org/10.1158/1078-0432.c.6518331.v1
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:338-349
Established guidelines have recommended a number of methods based on in vitro data to assess the CYP3A induction risk of new chemical entities in clinical practice. In this study, we evaluated the predictability of various assessment methods. We coll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d35e27173329eab6127b1c20b069ad0
https://doi.org/10.1248/bpb.b20-00578
https://doi.org/10.1248/bpb.b20-00578
Autor:
Akihisa Kaneko, Chihiro Endo-Tsukude, Motohiro Kato, Shino Kuramoto, Masaki Ishigai, Akinobu Hamada, Satofumi Iida
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:325-333
By using the Relative Factor (RF) method-a method that can simply assess cytochrome P450 (CYP) induction risk based on a maximum induction effect model-we evaluated the risk of CYP2C9 induction and examined its relationship with risk of CYP3A4 induct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc51075349ee3ab7655ad61350d87287
https://doi.org/10.1016/j.dmpk.2019.07.002
https://doi.org/10.1016/j.dmpk.2019.07.002
Autor:
Motohiro Kato, Hidetoshi Shindoh, Haruka Tsutsui, Nobuo Sekiguchi, Kazuhisa Ozeki, Shino Kuramoto
This is the first report quantitatively evaluating the clinical induction of CYP3A in the liver and the intestine.To evaluate hepatic induction, we collected literature data on endogenous biomarkers of hepatic CYP3A induction which we then used to ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae35ab178aee404ce1eb01e1cb1794e
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S42-S43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc35d5eb440d618514fc9ae9e92cfbfd
https://doi.org/10.1016/j.dmpk.2018.09.155
https://doi.org/10.1016/j.dmpk.2018.09.155
Autor:
Akihisa Kaneko, Masaki Ishigai, Seiji Miyauchi, Motohiro Kato, Shino Kuramoto, Hidetoshi Shindoh
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 45(11)
We investigated the robustness and utility of the relative factor (RF) approach based on the maximum induction effect (Emax) model, using the mRNA induction data of 10 typical CYP3A4 inducers in cryopreserved human hepatocytes. The RF value is design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d3e2b0d59e1b7f989e4cf00e15507f
https://pubmed.ncbi.nlm.nih.gov/28821485
https://pubmed.ncbi.nlm.nih.gov/28821485
Autor:
Ryuichi Komatsu, Mitsuyasu Tabo, Shino Kuramoto, Hidetoshi Shindoh, Takehito Isobe, Masaki Honda
Publikováno v:
The Journal of Toxicological Sciences. 39:237-242
Anti-angiogenic drugs that target Vascular Endothelial Growth Factor (VEGF) signaling pathways caused hypertension as an adverse effect in clinical studies. Since the hypertension may limit the benefit provided for patients, the demand for non-clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bae5231e2d5997ec2b015dd09e052f5d
https://doi.org/10.2131/jts.39.237
https://doi.org/10.2131/jts.39.237
Autor:
Takuo Tsukuda, Masami Hasegawa, Kihito Hada, Yuko Aoki, Nobuo Shimma, Tsutomu Ishikawa, Kohsuke Asoh, Hiroshi Koyano, Atsushi Suda, Yasuko Sato, Kotaro Ogawa, Shino Kuramoto
Publikováno v:
Bioorganicmedicinal chemistry. 20(4)
Proliferation of endothelial cells is critical for angiogenesis. We report orally available, in vivo active antiangiogenic agents which specifically inhibit endothelial cell proliferation. After identifying human umbilical vein endothelial cell (HUVE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580317722c5f4e5f4758ed921180b4c3
https://pubmed.ncbi.nlm.nih.gov/22269278
https://pubmed.ncbi.nlm.nih.gov/22269278
Autor:
Hiromi Tanimura, Kiyoaki Sakata, Toshikazu Yamazaki, Yuko Aoki, Toshihiko Fujii, Nobuya Ishii, Shino Kuramoto, Yukako Tachibana, Hirosato Ebiike, Jun Ohwada, Osamu Kondoh, Miyuki Yoshida, Hiroshi Tanaka, Yasushi Yoshimura, Keiichi Morita
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 17(10)
Purpose: The phosphatidylinositol 3-kinase (PI3K) pathway plays a central role in cell proliferation and survival in human cancer. PIK3CA mutations, which are found in many cancer patients, activate the PI3K pathway, resulting in cancer development a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01b8ac878c5d990451c854bdc933851
https://pubmed.ncbi.nlm.nih.gov/21558396
https://pubmed.ncbi.nlm.nih.gov/21558396