Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Shino Kondoh"'
Publikováno v:
2018 Portland International Conference on Management of Engineering and Technology (PICMET).
The productivity of pharmaceutical research and development (R&D) has steadily declined over the past 10 years. The value-based evaluation approach is expected to lead to a better understanding of the value structure of pharmaceutical products compar
Autor:
Yuko Shirode-Fukuda, Kazuki Inoue, Katsuhide Igarashi, Erina Inoue, Shino Kondoh, Jun Kanno, Taiyong Yu, Jun K. Takeuchi, Hiroe Sugizaki, Lynda F. Bonewald, Yuuki Imai
Publikováno v:
Bone. 60:68-77
Estrogens are well known steroid hormones necessary to maintain bone health. In addition, mechanical loading, in which estrogen signaling may intersect with the Wnt/β-catenin pathway, is essential for bone maintenance. As osteocytes are known as the
Autor:
Yukiko Kitase, Lynda F. Bonewald, Shino Kondoh, Mark L. Johnson, Hai Qing, Leonardo Barragan, Jean X. Jiang
Publikováno v:
Journal of Bone and Mineral Research
Glucocorticoids are known to induce osteocyte apoptosis, whereas mechanical loading has been shown to sustain osteocyte viability. Here we show that mechanical loading in the form of fluid-flow shear stress blocks dexamethasone-induced apoptosis of o
Autor:
Shino, Kondoh, Yuuki, Imai
Publikováno v:
Clinical calcium. 22(5)
Estrogen is well-known to play essential roles for maintenance of bone mass. Although its osteoprotective actions are mediated mainly through suppressing bone resorption, several reports has suggested that ERα/estrogen signal in osteocytes has some
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 24(5)
The osteoprotective action of estrogen in women has drawn considerable attention because estrogen deficiency-induced osteoporosis became one of the most widely spread diseases in developed countries. In men, the significance of estrogen action for bo
Autor:
Ming Young Youn, Shino Kondoh, Takahiro Matsumoto, Yuuki Imai, Ichiro Takada, Kunio Takaoka, Takashi Nakamura, Shigeaki Kato, Alexander Kouzmenko
Publikováno v:
Annals of the New York Academy of Sciences. 1173
Estrogens play a key role in regulation of bone mass and strength by controlling activity of bone-forming osteoblasts and bone-resorbing osteoclasts. Cellular effects of estrogens are mediated predominantly by the action of estrogen receptor alpha (E
Publikováno v:
Clinical calcium. 18(9)
Bone mass and strength is mediated by appropriate weight bearing, and it is clear that bone tissue senses and adopts mechanical stresses. However, the precise molecular mechanisms in mechanotransduction remain elusive. Recently, several studies clari
Publikováno v:
Molecular and cellular endocrinology. 310(1-2)
Bone tissue protects and supports soft organs and maintains calcium homeostasis. Steroid sex hormones and fat-soluble vitamins play a pivotal role in regulation of bone homeostasis, turnover and remodeling. These molecules act as ligands of nuclear r
Publikováno v:
Bone. 51:S5
Publikováno v:
Bone. 48:S152