Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Shinkichi Tawata"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract P21-activated kinases (PAKs) are serine/threonine protein kinase which have six different isoforms (PAK1–6). Of those, PAK1 is overexpressed in many cancers and considered to be a major chemotherapeutic target. Most of the developed PAK1 i
Externí odkaz:
https://doaj.org/article/97627965dec141f385e331f0e5a399ac
Autor:
Amirthalingam Mohankumar, Duraisamy Kalaiselvi, Govindhan Thiruppathi, Sivaramakrishnan Muthusaravanan, Subramaniam Vijayakumar, Rahul Suresh, Shinkichi Tawata, Palanisamy Sundararaj
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Transthyretin (TTR) is a homotetrameric protein found in human serum and is implicated in fatal inherited amyloidoses. Destabilization of native TTR confirmation resulting from mutation, environmental changes, and aging causes polymerization and amyl
Externí odkaz:
https://doaj.org/article/6c2b163b7052481093c362c2b22fe70c
Autor:
Amirthalingam Mohankumar, Duraisamy Kalaiselvi, Govindhan Thiruppathi, Sivaramakrishnan Muthusaravanan, Sundararaj Nivitha, Corey Levenson, Shinkichi Tawata, Palanisamy Sundararaj
Publikováno v:
ACS Omega, Vol 5, Iss 50, Pp 32641-32654 (2020)
Externí odkaz:
https://doaj.org/article/0b72606736704e229399ae60c10ad31f
Autor:
Pham Thi Be Tu, Shinkichi Tawata
Publikováno v:
Molecules, Vol 20, Iss 9, Pp 16723-16740 (2015)
Here, we investigated the anti-oxidant and anti-aging effects of essential oils (EOs) from the leaves of Alpinia zerumbet (tairin and shima) in vitro and anti-melanogenic effects in B16F10 melanoma cells. The anti-oxidant activities were performed wi
Externí odkaz:
https://doaj.org/article/37c6689250294d3c882cab562da7e4e2
Publikováno v:
Molecules, Vol 20, Iss 9, Pp 16741-16756 (2015)
Mimosine, a non-protein amino acid, is found in several tropical and subtropical plants, which has high value for medicine and agricultural chemicals. Here, in continuation of works aimed to development of natural product-based pesticidal agents, we
Externí odkaz:
https://doaj.org/article/4f7d5fefe97e42d184e3c742ad715d0c
Autor:
Binh Cao Quan Nguyen, Shinkichi Tawata
Publikováno v:
Molecules, Vol 20, Iss 8, Pp 14334-14347 (2015)
Melanogenesis plays an important role in the protection of skin against UV through production of melanin pigments, but abnormal accumulation of this pigment causes unaesthetic hyperpigmentation. Much effort is being made to develop effective depigmen
Externí odkaz:
https://doaj.org/article/e5ee84fbbef94aaf935818c45d03c28d
Autor:
Pham Thi Be Tu, Shinkichi Tawata
Publikováno v:
Molecules, Vol 19, Iss 10, Pp 16656-16671 (2014)
Obesity and its related disorders have become leading metabolic diseases. In the present study, we used 3T3-L1 adipocytes to investigate the anti-obesity activity of hispidin and two related compounds that were isolated from Alpinia zerumbet (alpinia
Externí odkaz:
https://doaj.org/article/5d90c4bbe9624984b46eff4a10d4e2ca
Publikováno v:
Molecules, Vol 17, Iss 6, Pp 6237-6248 (2012)
Oxidation of low-density lipoprotein (LDL) is the principal risk factor for the development of atherosclerosis. In this study, we used several methods to investigate the ability of the acetone extract from rhizomes, stems, leaves, flowers, pericarps
Externí odkaz:
https://doaj.org/article/674534fb93cb4644aeda25123c7a3acf
Autor:
Md Shahinozzaman, Nozomi Taira, Takahiro Ishii, Mohammad A. Halim, Md Amzad Hossain, Shinkichi Tawata
Publikováno v:
Molecules, Vol 23, Iss 10, p 2479 (2018)
Okinawa propolis (OP) and its major ingredients were reported to have anti-cancer effects and lifespan-extending effects on Caenorhabditis elegans through inactivation of the oncogenic kinase, p21-activated kinase 1 (PAK1). Herein, five prenylated fl
Externí odkaz:
https://doaj.org/article/2ca307b0fedb4030a1c4637322f96f8a
Autor:
Md Shahinozzaman, Takahiro Ishii, Ryo Takano, Mohammad A. Halim, Md Amzad Hossain, Shinkichi Tawata
Publikováno v:
Scientia Pharmaceutica, Vol 86, Iss 3, p 32 (2018)
Sea cucumbers have long been utilized in foods and Asiatic folk medicines for their nutritive and health benefits. Herein, three sea cucumber species were investigated and Holothuria atra showed the highest cytotoxicity among these. Next, a desulfate
Externí odkaz:
https://doaj.org/article/d12013bc3efd4a32973695e3e0ba1dc8