Continuous precipitation-filtration process for initial capture of a monoclonal antibody product using a four-stage countercurrent hollow fiber membrane washing step.

Autor: Minervini M; Department of Chemical Engineering, The Pennsylvania State University, State College, Pennsylvania, USA., Mergy M; Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA., Zhu Y; Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA., Gutierrez Diaz MA; Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA., Pointer C; ChromaTan, Inc., Gwynedd, Pennsylvania, USA., Shinkazh O; ChromaTan, Inc., Gwynedd, Pennsylvania, USA., Oppenheim SF; Takeda Pharmaceuticals, Cambridge, Massachusetts, USA., Cramer SM; Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA., Przybycien TM; Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA., Zydney AL; Department of Chemical Engineering, The Pennsylvania State University, State College, Pennsylvania, USA.

Publikováno v: Biotechnology and bioengineering [Biotechnol Bioeng] 2024 Aug; Vol. 121 (8), pp. 2258-2268. Date of Electronic Publication: 2023 Aug 10.

Continuous countercurrent tangential chromatography for mixed mode post-capture operations in monoclonal antibody purification.

Autor: Dutta AK; Chromatan Corporation, 200 Innovation Blvd., Suite 260B, State College, PA 16803, United States., Fedorenko D; Chromatan Corporation, 200 Innovation Blvd., Suite 260B, State College, PA 16803, United States., Tan J; Chromatan Corporation, 200 Innovation Blvd., Suite 260B, State College, PA 16803, United States., Costanzo JA; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States., Kahn DS; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States., Zydney AL; Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, United States., Shinkazh O; Chromatan Corporation, 200 Innovation Blvd., Suite 260B, State College, PA 16803, United States. Electronic address: oleg.shinkazh@chromatan.com.

Publikováno v: Journal of chromatography. A [J Chromatogr A] 2017 Aug 18; Vol. 1511, pp. 37-44. Date of Electronic Publication: 2017 Jun 22.

Purification of monoclonal antibodies from clarified cell culture fluid using Protein A capture continuous countercurrent tangential chromatography.

Autor: Dutta AK; Chromatan Corporation, 200 Innovation Blvd., Suite 260B, State College, PA 16803, United States; Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, United States., Tran T; Chromatan Corporation, 200 Innovation Blvd., Suite 260B, State College, PA 16803, United States., Napadensky B; Chromatan Corporation, 200 Innovation Blvd., Suite 260B, State College, PA 16803, United States., Teella A; Chromatan Corporation, 200 Innovation Blvd., Suite 260B, State College, PA 16803, United States., Brookhart G; Fujifilm Diosynth Biotechnologies, 101 J. Morris Commons Lane, Morrisville, NC 27560, United States., Ropp PA; Fujifilm Diosynth Biotechnologies, 101 J. Morris Commons Lane, Morrisville, NC 27560, United States., Zhang AW; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, United States., Tustian AD; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, United States., Zydney AL; Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, United States., Shinkazh O; Chromatan Corporation, 200 Innovation Blvd., Suite 260B, State College, PA 16803, United States. Electronic address: oleg.shinkazh@chromatan.com.

Publikováno v: Journal of biotechnology [J Biotechnol] 2015 Nov 10; Vol. 213, pp. 54-64. Date of Electronic Publication: 2015 Mar 05.

Continuous integrated manufacturing for biopharmaceuticals: A new paradigm or an empty promise?

Autor: Rathore AS; Department of Chemical Engineering, Indian Institute of Technology, New Delhi, India., Thakur G; Department of Chemical Engineering, Indian Institute of Technology, New Delhi, India., Kateja N; Department of Chemical Engineering, Indian Institute of Technology, New Delhi, India.

Publikováno v: Biotechnology and bioengineering [Biotechnol Bioeng] 2023 Feb; Vol. 120 (2), pp. 333-351. Date of Electronic Publication: 2022 Sep 28.

Recent Advances and Future Directions in Downstream Processing of Therapeutic Antibodies.

Autor: Matte, Allan¹ (AUTHOR) allan.matte@nrc-cnrc.gc.ca

Publikováno v: International Journal of Molecular Sciences. Aug2022, Vol. 23 Issue 15, p8663-8663. 13p.