SNP Discrimination by Tolane-Modified Peptide Nucleic Acids: Application for the Detection of Drug Resistance in Pathogens

Autor: Kenji Takagi, Tenko Hayashi, Shinjiro Sawada, Miku Okazaki, Sakiko Hori, Katsuya Ogata, Nobuo Kato, Yasuhito Ebara, Kunihiro Kaihatsu

Publikováno v: Molecules, Vol 25, Iss 4, p 769 (2020)

During the treatment of viral or bacterial infections, it is important to evaluate any resistance to the therapeutic agents used. An amino acid substitution arising from a single base mutation in a particular gene often causes drug resistance in path

Externí odkaz: https://doaj.org/article/8ed38034e15b4f0993e8707f55a99a1d

Sequence-specific and visual identification of the influenza virus NS gene by azobenzene-tethered bis-peptide nucleic acid.

Autor: Kunihiro Kaihatsu, Shinjiro Sawada, Shota Nakamura, Takaaki Nakaya, Teruo Yasunaga, Nobuo Kato

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e64017 (2013)

To rapidly and specifically identify highly virulent influenza virus strains, we prepared an azobenzene-tethered hairpin-type peptide nucleic acid, bisPNA-AZO, which has a complementary sequence against a highly conserved genomic RNA sequence within

Externí odkaz: https://doaj.org/article/92320d845a224408beecc254ef154601

Design of Tail-Clamp Peptide Nucleic Acid Tethered with Azobenzene Linker for Sequence-Specific Detection of Homopurine DNA

Autor: Nobuo Kato, Toshifumi Takao, Shinjiro Sawada, Kunihiro Kaihatsu

Publikováno v: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules; Volume 22; Issue 11; Pages: 1840
Molecules, Vol 22, Iss 11, p 1840 (2017)

DNA carries genetic information in its sequence of bases. Synthetic oligonucleotides that can sequence-specifically recognize a target gene sequence are a useful tool for regulating gene expression or detecting target genes. Among the many synthetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b158104364e1f7f98cea1d9bd29c595
https://pubmed.ncbi.nlm.nih.gov/29077023

Rapid Identification of Swine-Origin Influenza A Virus by Peptide Nucleic Acid Chromatography

Autor: Shinjiro Sawada, Nobuo Kato, Kunihiro Kaihatsu

Publikováno v: Journal of Antivirals & Antiretrovirals.

Early and rapid detection of a virus infection is crucial for preventing transmission and initiating treatment. The sequence-specific detection of a target viral gene has been used to diagnose not only a virus infection, but also the virus strain, cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::baee43f983f8287e6706ef69a7b87161
https://doi.org/10.4172/jaa.1000067