Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Shinji Takasu"'
Autor:
Takeshi Toyoda, Masami Yamamoto, Shinji Takasu, Kumiko Ogawa, Masae Tatematsu, Tetsuya Tsukamoto
Publikováno v:
Diseases, Vol 2, Iss 2, Pp 168-186 (2014)
Since the discovery of Helicobacter pylori (H. pylori), many efforts have been made to establish animal models for the investigation of the pathological features and molecular mechanisms of gastric carcinogenesis. Among the animal models, Mongolian g
Externí odkaz:
https://doaj.org/article/36c6863219d04eb0a7798931de336906
Publikováno v:
Biochemistry Research International, Vol 2012 (2012)
Epidemiological studies have shown that serum triglyceride (TG) levels are linked with risk of development of cancer, including colorectal and pancreatic cancers, and their precancerous lesions. Thus, it is assumed that serum TG plays an important ro
Externí odkaz:
https://doaj.org/article/728c9b9aae9d40d9bb2739de9d4859c6
Autor:
Takanori Yamada, Takeshi Toyoda, Shinji Takasu, Yuji Ishii, Kohei Matsushita, Tomomi Morikawa, Kumiko Ogawa
Publikováno v:
Archives of Toxicology. 95:3117-3131
1,3-Dichloro-2-propanol (1,3-DCP), a food contaminant, exerts carcinogenic effects in multiple organs, including the liver and kidneys, in rats. However, the underlying mechanisms of 1,3-DCP-induced carcinogenesis remain unclear. Here, the in vivo mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b389e4c604df6940585a45b524dbd989
https://doi.org/10.1007/s00204-021-03120-1
https://doi.org/10.1007/s00204-021-03120-1
Autor:
Shinji Takasu, Yuji Ishii, Moeka Namiki, Kenji Nakamura, Tatsuya Mitsumoto, Norifumi Takimoto, Takehiko Nohmi, Kumiko Ogawa
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
The safety of flavoring agents has been evaluated according to classification by chemical structure and using a decision tree approach. The genotoxic potential found in some flavoring agents has highlighted the importance of efficient toxicity studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6089f633596b5db0b4cf32464cafe3b
https://pubmed.ncbi.nlm.nih.gov/36464108
https://pubmed.ncbi.nlm.nih.gov/36464108
Autor:
Yuji Ishii, Petr Grúz, Kumiko Ogawa, Shinji Takasu, Takashi Umemura, Kenichi Masumura, Takehiko Nohmi
Publikováno v:
Mutagenesis. 36:155-164
DNA polymerase zeta (Polζ) is a heterotetramer composed of the catalytic subunit Rev3l, Rev7 and two subunits of Polδ (PolD2/Pol31 and PolD3/Pol32), and this polymerase exerts translesion DNA synthesis (TLS) in yeast. Because Rev3l knockout results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083db8f48a651856e8cc36c8836507da
https://doi.org/10.1093/mutage/geab007
https://doi.org/10.1093/mutage/geab007
Autor:
Yuji Ishii, Aki Kijima, Kumiko Ogawa, Kohei Matsushita, Takehiko Nohmi, Takashi Umemura, Hisayoshi Takagi, Ken Kuroda, Shinji Takasu
Publikováno v:
Journal of Toxicologic Pathology. 34:23-31
Although gpt delta rats, as reporter gene-transgenic rats, were originally developed for in vivo mutation assays, they have also been used to evaluate chemical carcinogenesis and comprehensive toxicity. Therefore, it is necessary to accumulate backgr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fcd5826fcc041c8e47d9fa5c37e9f60
https://doi.org/10.1293/tox.2020-0060
https://doi.org/10.1293/tox.2020-0060
Publikováno v:
Toxicologic Pathology. 48:756-765
Glutathione S-transferase placental form-positive (GST-P+) foci are markers of preneoplastic lesions in rat hepatocarcinogenesis. Our previous studies using reporter gene transgenic rats showed that furan, a hepatocarcinogen in rodents, rapidly induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb8402a0740d0eeb511f31eb5ce39398
https://doi.org/10.1177/0192623320948782
https://doi.org/10.1177/0192623320948782
Autor:
Yuji Ishii, Kenji Nakamura, Tatsuya Mitsumoto, Norifumi Takimoto, Moeka Namiki, Shinji Takasu, Kumiko Ogawa
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 161
Madder color (MC), a natural dye isolated from Rubia tinctorum, is a potent carcinogen that targets the outer stripe of outer medulla (OSOM) in the kidneys of rats. To clarify the role of MC components in renal carcinogenesis, we examined distributio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6348a45b9de637a2077389215cfbb3
https://pubmed.ncbi.nlm.nih.gov/35139434
https://pubmed.ncbi.nlm.nih.gov/35139434
Lack of genotoxic mechanisms in isoeugenol-induced hepatocellular tumorigenesis in male B6C3F1 mice.
Autor:
Yuji Ishii, Moeka Namiki, Shinji Takasu, Kenji Nakamura, Norifumi Takimoto, Tatsuya Mitsumoto, Kumiko Ogawa
Publikováno v:
Japanese Journal of Food Chemistry & Safety; 2023, Vol. 30 Issue 1, p9-22, 14p
Autor:
Ken, Kuroda, Yuji, Ishii, Shinji, Takasu, Kohei, Matsushita, Aki, Kijima, Takehiko, Nohmi, Takashi, Umemura
Publikováno v:
Food and Chemical Toxicology. 168:113365
2-Methylfuran (2-MF) exists naturally in foods and is used as a flavoring agent. Furan, the core structure of 2-MF, possesses hepatocarcinogenicity in rodents. Accumulation of toxicological information on furan derivatives is needed to elucidate thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9c1f2d35b6ba6cb85cf0fe9e983818
https://doi.org/10.1016/j.fct.2022.113365
https://doi.org/10.1016/j.fct.2022.113365