Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Shinji Sunada"'
Autor:
Daiki Sakai, Kazutoshi Watanabe, Mika Nabeno, Hiroshi Tanaka, Shinji Tanaka, Shinji Sunada, Jun-ichi Eguchi, Keiko Takiguchi-Hayashi, Ken-Ichi Saito, Shin-ichi Kusaka, Kazuki Nakayama, Kenji Fukunaga, Toshiyuki Kohara, Tomoko Bessho, Takashi Horikawa, Akiko Mori
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(16)
We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 3-methylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55de72f14f1f283259756ae9c42b53f
https://pubmed.ncbi.nlm.nih.gov/28712706
https://pubmed.ncbi.nlm.nih.gov/28712706
Autor:
Adachi Takashi, Narihiko Yoshii, Kazutoshi Watanabe, Fumiaki Uehara, Mika Nabeno, Takashi Horikawa, Kenji Fukunaga, Ken-Ichi Saito, Shinji Sunada, Satoshi Yokoshima, Shinji Tanaka, Satoshi Yuki, Shouichi Asano, Aya Shouda, Hiroshi Tanaka, Shinsuke Hiki, Keiichi Aritomo, Masatake Fujimura, Keiji Yamagami, Yoshihiro Usui, Jun-ichi Eguchi
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(16)
We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 2-phenylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15af65e99a9d19a8f0c2d46937023c5e
https://pubmed.ncbi.nlm.nih.gov/28712708
https://pubmed.ncbi.nlm.nih.gov/28712708
Autor:
Jun-ichi Eguchi, Shinsuke Hiki, Masatake Fujimura, Satoshi Yuki, Shinji Sunada, Tokushi Hanano, Masahiro Okuyama, Fumiaki Uehara, Toshiyuki Kohara, Hiroshi Tanaka, Keiichi Aritomo, Susumu Tsuchiya, Ken-Ichi Saito, Kenji Fukunaga, Kazutoshi Watanabe, Shoichi Asano, Koichi Yamakoshi, Hiroshi Baba, Shinji Tanaka, Takashi Horikawa, Yoshihiro Usui, Aya Shoda, Akiko Mori, Keiji Yamagami
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6933-6937
A series of 2-(2-phenylmorpholin-4-yl)pyrimidin-4(3H)-ones was synthesized and examined for their inhibitory activity against glycogen synthase kinase-3β (GSK-3β). We found 21, 29 and 30 to possess potent in vitro GSK-3β inhibitory activity with g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a885218d2050bd32f637b9c4aaa1822
https://doi.org/10.1016/j.bmcl.2013.09.020
https://doi.org/10.1016/j.bmcl.2013.09.020
Publikováno v:
Biophysical Chemistry. :119-126
Accurate methods to predict the binding affinities of compounds for target molecules are powerful tools in structure-based drug design (SBDD). A recently developed method called massively parallel computation of absolute binding free energy with a we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ddbdc675edff174359b8d1375e5f91a
https://doi.org/10.1016/j.bpc.2013.07.005
https://doi.org/10.1016/j.bpc.2013.07.005
Autor:
Hiroko Suzuki, Hiroaki Ueno, Shinji Sunada, Akiko Kashima, Tomofumi Setsuta, Akira Nakao, Hiroshi Iwasaki
Publikováno v:
Bioorganicmedicinal chemistry. 23(15)
Optimization of a new series of S-adenosyl-L-homocysteine hydrolase (AdoHcyase) inhibitors based on non-adenosine analogs led to very potent compounds 14n, 18a, and 18b with IC50 values of 13 ± 3, 5.0 ± 2.0, and 8.5 ± 3.1 nM, respectively. An X-ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a09eba8edfd45841e41beef8acc4b0
https://pubmed.ncbi.nlm.nih.gov/26037610
https://pubmed.ncbi.nlm.nih.gov/26037610
Autor:
Ryoichi Ando, Satoshi Yuki, Takuro Niwa, Takahide Kaji, Hiroaki Ueno, Hideo Kubodera, Ken-Ichi Saito, Jun-ichi Eguchi, Kenji Fukunaga, Shoichi Asano, Fumiaki Uehara, Keiichi Aritomo, Shinji Sunada, Aya Shoda, Masaki Shinoda, Shinji Tanaka, Yukimi Yoneyama, Kazutoshi Watanabe
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(24)
The discovery of a series of 6-(4-pyridyl)pyrimidin-4(3H)-ones derived from a hit compound with low molecular weight and sufficient chemical space is reported. Transformation of substituents led to subnanomolar potent inhibitors with in vivo tau phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b5fb6d1bc6f131ecb58c4142b376e8
https://pubmed.ncbi.nlm.nih.gov/24094818
https://pubmed.ncbi.nlm.nih.gov/24094818
Publikováno v:
The Journal of Chemical Physics. 104:4768-4775
An analytic formula is developed for calculating the generalized NMR order parameters in a protein from the normal mode analysis (NMA). The generalized order parameter, S2, is given as thermal ensemble average of a Taylor series in powers of Δ, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a01af184c753595f9882192789d6b03f
https://doi.org/10.1063/1.471170
https://doi.org/10.1063/1.471170
Autor:
Nobuhiro Go, Shinji Sunada
Publikováno v:
Journal of Computational Chemistry. 16:328-336
An analytic expression for protein atomic displacements in Cartesian coordinate space (CCS) against small changes in dihedral angles is derived. To study time-dependent dynamics of a native protein molecule in CCS from dynamics in the internal coordi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fffbcfc9153525391eded7c55880d01
https://doi.org/10.1002/jcc.540160307
https://doi.org/10.1002/jcc.540160307
Autor:
Koichi Ohno, Shinji Sunada
Publikováno v:
Proceedings / Indian Academy of Sciences. 106:327-337
Potential energy contour curves for some simple molecules interacting with a test atom (a Li atom in the ground state) are calculated by theab initio method. Relative hardness of the repulsive molecular surface is found to be anisotropic. This indica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c634be8b2279848232d35d8a31910a72
https://doi.org/10.1007/bf02840754
https://doi.org/10.1007/bf02840754
Autor:
Akiko Kashima, Hiroshi Iwasaki, Shinji Sunada, Hiroko Suzuki, Akira Nakao, Tomofumi Setsuta, Hiroaki Ueno
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:6078
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::013052fedddf7457681948fd95b99df8
https://doi.org/10.1016/j.bmc.2015.07.063
https://doi.org/10.1016/j.bmc.2015.07.063