Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Shinji Saiki"'
Comprehensive data for studying serum exosome microRNA transcriptome in Parkinson’s disease patients
Autor:
Zhiyang Yu, Shinji Saiki, Kenta Shiina, Tatou Iseki, Yukiko Sasazawa, Kei-Ichi Ishikawa, Noriko Nishikawa, Wataru Sako, Genko Oyama, Taku Hatano, Ayami Suzuki, Sanae Souma, Tetsushi Kataura, Nobutaka Hattori
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-9 (2024)
Abstract Parkinson’s disease (PD), the second most prevalent neurodegenerative disorder, was classically attributed to alpha-synuclein aggregation and consequent loss of dopaminergic neurons in the substantia nigra pars compacta. Recently, emerging
Externí odkaz:
https://doaj.org/article/7eb24d468663497d88daad6924f560b4
Autor:
Michihide Kajita, MD, Kiyoyuki Yanaka, MD, PhD, Hayato Takeda, MD, Minami Saura, MD, Toshihide Takahashi, MD, PhD, Hitoshi Aiyama, MD, PhD, Shinji Saiki, MD, PhD, Eiichi Ishikawa, MD, PhD
Publikováno v:
Radiology Case Reports, Vol 19, Iss 12, Pp 5633-5638 (2024)
The choroid plexus is the secretory tissue responsible for cerebrospinal fluid production in the brain. Ischemia of the choroid plexus is rare because of its abundant blood supply from multiple arterial systems, including the anterior and posterior c
Externí odkaz:
https://doaj.org/article/5c6b41916f414eeb8ba0151174da8ca5
Autor:
Tetsushi Kataura, Lucia Sedlackova, Congxin Sun, Gamze Kocak, Niall Wilson, Peter Banks, Faisal Hayat, Sergey Trushin, Eugenia Trushina, Oliver D. K. Maddocks, John E. Oblong, Satomi Miwa, Masaya Imoto, Shinji Saiki, Daniel Erskine, Marie E. Migaud, Sovan Sarkar, Viktor I. Korolchuk
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-13 (2024)
Abstract Impairment of autophagy leads to an accumulation of misfolded proteins and damaged organelles and has been implicated in plethora of human diseases. Loss of autophagy in actively respiring cells has also been shown to trigger metabolic colla
Externí odkaz:
https://doaj.org/article/5f963d5a91c847e89f73c916ea6f3cee
Autor:
Yuki Date, Yukiko Sasazawa, Mitsuhiro Kitagawa, Kentaro Gejima, Ayami Suzuki, Hideyuki Saya, Yasuyuki Kida, Masaya Imoto, Eisuke Itakura, Nobutaka Hattori, Shinji Saiki
Publikováno v:
eLife, Vol 13 (2024)
The autophagy-lysosome pathway plays an indispensable role in the protein quality control by degrading abnormal organelles and proteins including α-synuclein (αSyn) associated with the pathogenesis of Parkinson’s disease (PD). However, the activa
Externí odkaz:
https://doaj.org/article/8470589af0444bb5ad7fc67f5fcc1f2a
Autor:
Genko Oyama, Maximilien Burq, Taku Hatano, William J. Marks, Ritu Kapur, Jovelle Fernandez, Keita Fujikawa, Yoshihiko Furusawa, Keisuke Nakatome, Erin Rainaldi, Chen Chen, King Chung Ho, Takashi Ogawa, Hikaru Kamo, Yutaka Oji, Haruka Takeshige-Amano, Daisuke Taniguchi, Ryota Nakamura, Fuyuko Sasaki, Shinichi Ueno, Kenta Shiina, Anri Hattori, Noriko Nishikawa, Mayu Ishiguro, Shinji Saiki, Ayako Hayashi, Masatoshi Motohashi, Nobutaka Hattori
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Continuous, objective monitoring of motor signs and symptoms may help improve tracking of disease progression and treatment response in Parkinson’s disease (PD). This study assessed the analytical and clinical validity of multi-sensor smar
Externí odkaz:
https://doaj.org/article/eca698ce76b243348283baa494b268d1
Autor:
Tomoko Nakazato, Kazuaki Kanai, Tetsushi Kataura, Shuko Nojiri, Nobutaka Hattori, Shinji Saiki
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Although various body fluid biomarkers for amyotrophic lateral sclerosis (ALS) have been reported, no biomarkers specifically reflecting abnormalities in axonal excitability indices have currently been established. Capillary electrophoresis
Externí odkaz:
https://doaj.org/article/f4fef6935c904b78a2aaa3b02852cfa9
Autor:
Yuya Uehara, Shin-Ichi Ueno, Haruka Amano-Takeshige, Shuji Suzuki, Yoko Imamichi, Motoki Fujimaki, Noriyasu Ota, Takatoshi Murase, Takayoshi Inoue, Shinji Saiki, Nobutaka Hattori
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Parkinson's disease (PD) is a progressive neurodegenerative disease presenting with motor and non-motor symptoms, including skin disorders (seborrheic dermatitis, bullous pemphigoid, and rosacea), skin pathological changes (decreased nerve e
Externí odkaz:
https://doaj.org/article/8d5af2acda0847b59720e17cde503ddc
Autor:
Atsuo Nakamura, Shin Kurihara, Daisuke Takahashi, Wakana Ohashi, Yutaka Nakamura, Shunsuke Kimura, Masayoshi Onuki, Aiko Kume, Yukiko Sasazawa, Yukihiro Furusawa, Yuuki Obata, Shinji Fukuda, Shinji Saiki, Mitsuharu Matsumoto, Koji Hase
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Polyamines produced by intestinal bacteria are thought to have beneficial effects on the host. Here the authors show that these polyamines increase regulatory macrophage abundance and are taken up by colonic epithelial cells to enhance colonic barrie
Externí odkaz:
https://doaj.org/article/1cb82238883f4fe38505d0a785204d7e
Autor:
Shin‐Ichi Ueno, Taku Hatano, Ayami Okuzumi, Shinji Saiki, Yutaka Oji, Akio Mori, Takahiro Koinuma, Motoki Fujimaki, Haruka Takeshige‐Amano, Akihide Kondo, Naoyuki Yoshikawa, Takahiro Nojiri, Makoto Kurano, Keiko Yasukawa, Yutaka Yatomi, Hitoshi Ikeda, Nobutaka Hattori
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 3, Pp 307-317 (2020)
Abstract Objective To investigate the oxidized albumin ratio, which is the redox ratio of human nonmercaptalbumin (HNA) to serum albumin (%HNA), as a biomarker in idiopathic Parkinson’s disease (iPD) and related neurodegenerative disorders. Methods
Externí odkaz:
https://doaj.org/article/e9eda1b5376749098574688418ee6a8b
Autor:
Nobutaka Hattori, Ryota Nakamura, Naotake Yanagisawa, Takashi Ogawa, Kenya Nishioka, Shinji Saiki, Yasushi Shimo, Hiroto Eguchi, Taku Hatano, Kotaro Ogaki, Genko Oyama, Noriko Nishikawa, Jiro Fukae, Naohide Kurita, Taiji Tsunemi, Yutaka Oji, Haruka Takeshige-Amano, Daisuke Taniguchi, Hikaru Kamo, Atsuhito Fuse, Asuka Nakajima, Masayoshi Kano, Sho Nakajima
Publikováno v:
BMJ Open, Vol 12, Iss 2 (2022)
Externí odkaz:
https://doaj.org/article/81203ff80de541cd81029ad260e0b4d5