Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Shinji Kusakawa"'
Autor:
Takeshi Watanabe, Satoshi Yasuda, Shinji Kusakawa, Takuya Kuroda, Hatsue Furukawa, Mayumi Futamura, Shigekazu Shimizu, Akihiko Morishita, Shinko Hata, Akiko Koeda, Kana Komatsu, Yoji Sato
Publikováno v:
Regenerative Therapy, Vol 26, Iss , Pp 315-323 (2024)
Introduction: MEASURE2 (Multisite Evaluation Study on Analytical Methods for Non-clinical Safety Assessment of HUman-derived REgenerative Medical Products 2) is a Japanese experimental public–private partnership initiative that aims to standardize
Externí odkaz:
https://doaj.org/article/912fe7017d9e4325ae16d6184b69c4af
Autor:
Takamasa Hirai, Ken Kono, Shinji Kusakawa, Satoshi Yasuda, Rumi Sawada, Akihiko Morishita, Shinko Hata, Atsushi Wakita, Takayasu Kageyama, Ryo Takahashi, Sono Watanabe, Norihiko Shiraishi, Yoji Sato
Publikováno v:
Regenerative Therapy, Vol 21, Iss , Pp 540-546 (2022)
Introduction: Contamination of human cell-processed therapeutic products (hCTPs) with tumorigenic/immortalized cellular impurities is a major concern in the manufacturing and quality control of hCTPs. The cellular immortality test based on cell growt
Externí odkaz:
https://doaj.org/article/e9d27fb61bcb42359e4bdeae71d42de3
Autor:
Takuya Kuroda, Satoshi Yasuda, Shiori Tachi, Satoko Matsuyama, Shinji Kusakawa, Keiko Tano, Takumi Miura, Akifumi Matsuyama, Yoji Sato
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Human induced pluripotent stem cells (hiPSCs) generate all cell types in the body, but different lines can differ in their potential. Here, the authors determine that higher endogenous levels of SALL3 in hiPSCs lead to ectoderm differentiation bias a
Externí odkaz:
https://doaj.org/article/46ec5862781d440890248a463ec73ca6
Publikováno v:
Applied Sciences, Vol 11, Iss 20, p 9755 (2021)
Automated detection of impurities is in demand for evaluating the quality and safety of human cell-processed therapeutic products in regenerative medicine. Deep learning (DL) is a powerful method for classifying and recognizing images in cell biology
Externí odkaz:
https://doaj.org/article/025766a86f5848ea9aed766f4aae37a9
Autor:
Takuya Kuroda, Satoshi Yasuda, Hiroyuki Nakashima, Nozomi Takada, Satoko Matsuyama, Shinji Kusakawa, Akihiro Umezawa, Akifumi Matsuyama, Shin Kawamata, Yoji Sato
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Human pluripotent stem cells (hPSCs) are leading candidate raw materials for cell-based therapeutic products (CTPs). In the development of hPSC-derived CTPs, it is imperative to ensure that they do not form tumors after transplantation for s
Externí odkaz:
https://doaj.org/article/0840e66561c64d6fbe8d79444de7b309
Autor:
Satoshi Yasuda, Shinji Kusakawa, Takuya Kuroda, Takumi Miura, Keiko Tano, Nozomi Takada, Satoko Matsuyama, Akifumi Matsuyama, Michiyo Nasu, Akihiro Umezawa, Takao Hayakawa, Hideki Tsutsumi, Yoji Sato
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205022 (2018)
Human induced pluripotent stem cells (hiPSCs) represent promising raw materials of human cell-based therapeutic products (hCTPs). As undifferentiated hiPSCs exhibit intrinsic tumorigenicity properties that enable them to form teratomas, hCTPs contain
Externí odkaz:
https://doaj.org/article/e05fc1f3ac01447fbc2ef9c5fa9e15af
Autor:
Shinji Kusakawa, Kazuhiko Machida, Satoshi Yasuda, Nozomi Takada, Takuya Kuroda, Rumi Sawada, Hanayuki Okura, Hideki Tsutsumi, Shin Kawamata, Yoji Sato
Publikováno v:
Regenerative Therapy, Vol 1, Iss C, Pp 30-37 (2015)
The contamination of human cell-processed therapeutic products (hCTPs) with tumorigenic cells is one of the major concerns in the manufacturing and quality control of hCTPs. However, no quantitative method for detecting the tumorigenic cellular impur
Externí odkaz:
https://doaj.org/article/c476e3b89b7a4be5b39447e6839d167d
Autor:
Takuya Kuroda, Satoshi Yasuda, Shinji Kusakawa, Naoya Hirata, Yasunari Kanda, Kazuhiro Suzuki, Masayo Takahashi, Shin-Ichi Nishikawa, Shin Kawamata, Yoji Sato
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37342 (2012)
Human induced pluripotent stem cells (hiPSCs) possess the capabilities of self-renewal and differentiation into multiple cell types, and they are free of the ethical problems associated with human embryonic stem cells (hESCs). These characteristics m
Externí odkaz:
https://doaj.org/article/0fc98bb009b145de9d23e69175cc4b0a
Autor:
Akifumi Matsuyama, Shiori Tachi, Takumi Miura, Shinji Kusakawa, Satoko Matsuyama, Satoshi Yasuda, Yoji Sato, Keiko Tano, Takuya Kuroda
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Clinical applications of human induced pluripotent stem cells (hiPSCs) are expected, but hiPSC lines vary in their differentiation propensity. For efficient selection of hiPSC lines suitable for differentiation into desired cell lineages, here we ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07cd00366ed13e9a874ed1635ddaed55
http://link.springer.com/article/10.1038/s41467-019-09511-4
http://link.springer.com/article/10.1038/s41467-019-09511-4
Autor:
Yoji Sato, Masato Nagaoka, Mitsuhide Ogawa, Takuya Kuroda, Takeshi Watanabe, Hidemi Mochizuki, Eri Kikkawa, Hatsue Furukawa, Shinji Kusakawa, Satoshi Yasuda, Mayumi Futamura
Publikováno v:
Cytotherapy. 23(2)
MEASURE (Multisite Evaluation Study on Analytical Methods for Non-clinical Safety Assessment of HUman-derived REgenerative Medical Products) is a Japanese experimental public-private partnership initiative, which aims to standardize methodology for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf613de6a46c4804f2a14f65aac8eb6
https://pubmed.ncbi.nlm.nih.gov/32978066
https://pubmed.ncbi.nlm.nih.gov/32978066